Retracted: Melatonin stimulates the growth of new bone around implants in the tibia of rabbits

Abstract

This study evaluated the effect of the topical application of melatonin in accelerating bone formation associated with implants 2 months after their application to the tibiae of rabbits. Twenty New Zealand rabbits were used. Twenty implants treated with melatonin and 20 control implants without melatonin were placed in the proximal metaphyseal area of each tibia. Studies of new bone formation were subsequently made at 15, 30, 45 and 60 days. Cortical width and cortical length of new bone formation were measured. Following implantation, an anteroposterior and lateral radiologic study was carried out. Collected samples were sectioned at 5 μm and stained using hematoxylin-eosin, Masson's trichromic and Gordon-Switt reticulin stains. After a 60 day treatment period, melatonin increased the length of cortical bone (95.13±0.42%) versus that around control implants (62.91±1.45%). Related to the perimeter of cortical bone of the tibiae, melatonin induced new bone 88.35±1.56% versus 60.20±1.67% in the control implants. Melatonin regenerated the width and length of cortical bone around implants in tibiae of rabbits more quickly than around control implants without the addition of melatonin.

Evaluation of periimplant bone neoformation using different scanning electron microscope methods for measuring BIC. A dog study.

“…Although there may be good BIC levels, if the neoformed bone is of low quality with low calcium content, implant retention will be less than expected and long-term stability may be compromised (8). Studies involving elemental analysis used for this purpose are few; indeed, our review of studies involving BIC evaluation have identified only one that includes elemental analysis.…”

Melatonin Effects on Hard Tissues: Bone and Tooth

“…[32,33]. Previous studies have indicated that melatonin may play an important role in the bone-healing process due to its antioxidant properties, regulation of bone cells, and promotion of angiogenesis actions [33,34]. …”

Melatonin: A Novel Indolamine in Oral Health and Disease

“…In general, implants impregnated with topical melatonin at the time of placement showed more trabecular bone and higher trabecular density at implant contact [40, 41]. Osseointegration was reported to be more effective when melatonin was mixed with collagenised porcine bone [42, 43]. Melatonin at micro-molecular concentration promotes the proliferation of human mandibular cells (HOB-M) and cells of a human osteoblastic cellular line (SV-HFO).…”