<i>Retracted</i>: MicroRNA‐29a inhibits proliferation and motility of schwannoma cells by targeting CDK6

Ma, Ji; Li, Tengfei; Yuan, Hong; Han, Xinwei; Shui, Shaofeng; Guo, Dong; Yan, Lei

doi:10.1002/jcb.26426

Cited by 13 publications

(8 citation statements)

References 31 publications

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“…In schwannoma, miR-29a has been shown to downregulate CDK6 expression and disrupt cell cycle progression by the deactivation of JNK and p38MAPK/ERK pathways. Overexpression of all three members of the miR-29 family in Schwann cells inhibited cell viability, migration, and invasion in vitro 113 …”

Section: Main Textmentioning

confidence: 98%

A Systematic Review of miR-29 in Cancer

Kwon

Factora

Dey

et al. 2019

Molecular Therapy - Oncolytics

194

158

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MicroRNAs (miRNA) are small non-coding RNAs (∼22 nt in length) that are known as potent master regulators of eukaryotic gene expression. miRNAs have been shown to play a critical role in cancer pathogenesis, and the misregulation of miRNAs is a well-known feature of cancer. In recent years, miR-29 has emerged as a critical miRNA in various cancers, and it has been shown to regulate multiple oncogenic processes, including epigenetics, proteostasis, metabolism, proliferation, apoptosis, metastasis, fibrosis, angiogenesis, and immunomodulation. Although miR-29 has been thoroughly documented as a tumor suppressor in the majority of studies, some controversy remains with conflicting reports of miR-29 as an oncogene. In this review, we provide a systematic overview of miR-29’s functional role in various mechanisms of cancer and introspection on the contradictory roles of miR-29.

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Section: Main Textmentioning

confidence: 98%

A Systematic Review of miR-29 in Cancer

Kwon

Factora

Dey

et al. 2019

Molecular Therapy - Oncolytics

194

158

View full text Add to dashboard Cite

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“…MiR-29 family ( miR-29a, miR-29b , and miR-29c ) was connected with aggressiveness and prognosis of malignant neoplasms and might act as a considerable biomarker for forecasting the recurrence and progression of cancers [ 12 – 15 ]. Nonetheless, from articles we have learnt that miR-29a and miR-29b appeared to be more effective than miR-29c in targetting genes and signaling pathways [ 16 , 17 ]. The role of miR-29b in cancers had been fully discussed by Yan et al [ 18 ] in 2015 and the new progression of miR-29b was less.…”

Section: Introductionmentioning

confidence: 99%

MiR-29a: a potential therapeutic target and promising biomarker in tumors

et al. 2018

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MiRNAs, small non-coding RNA molecules, were recognized to be associated with the incidence and development of diverse neoplasms. MiRNAs were small non-coding RNAs that could regulate post-transcriptional level by binding to 3′-UTR of target mRNAs. Amongst which, miR-29a was demonstrated that it had significant impact on oncogenicity in various neoplasms through binding to critical genes which enhanced or inhibited the progression of cancers. MiR-29a participated in kinds of physiological and pathological processes, including virus replication, cell proliferation, differentiation, apoptosis, fibrosis, angiogenesis, tumorigenicity, metastasis, drug-resistance, and so on. According to its sufficient sensitivity and specificity, many studies showed that miR-29a might serve as a potential therapeutic target and promising biomarker in various tumors. In this review, we discussed the functions of miR-29a and its potential application in the diagnosis, treatment and stages of carcinoma, which could provide additional insight to develop a novel therapeutic strategy.

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“…Shin et al found that miR-29b effect on glioblastoma was suppressive (21). Ma et al stated that, miR-29 suppressed schwannoma cell proliferation and motility by regulating CDK6 (22). In colon cancer, miR-29 showed inhibitory effect on cell invasion and migration by regulating MMP2 (23).…”

Section: Introductionmentioning

confidence: 99%

miR-29 promotes osteosarcoma cell proliferation and migration by targeting PTEN

et al. 2018

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Osteosarcoma (OS) is an aggressive malignant neoplasm that arises from primitively transformed cells of mesenchymal origin, and that exhibits osteoblastic differentiation and produces malignant osteoid. MicroRNAs (miRNAs) have been widely reported to have important regulatory roles in various human tumors, including OS. However, the potential mechanism of miR-29 in OS remains largely unknown. miR-29 was highly expressed in OS and overexpression of miR-29 promoted OS cell proliferation, as well as proliferating cell nuclear antigen (PCNA) expression and migration, whereas lower expression of miR-29 inhibited OS cell proliferation, PCNA expression and migration. In the present study, a dual-luciferase reporter system supporting phosphatase and tensin homolog (PTEN) was a target of miR-29 and its expression was inhibited by miR-29 mimic, but increased by miR-29 inhibitor. Overexpression of PTEN inhibited OS cell proliferation and migration and it could attenuate miR-29 promotion effect on OS progression. Overall, the results revealed that miR-29, as a tumor promoter, is involved in OS progression and metastasis by targeting PTEN, indicating that the miR-29/PTEN pathway is a potential therapeutic target for the treatment of OS.

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Retracted: MicroRNA‐29a inhibits proliferation and motility of schwannoma cells by targeting CDK6

Cited by 13 publications

References 31 publications

A Systematic Review of miR-29 in Cancer

A Systematic Review of miR-29 in Cancer

MiR-29a: a potential therapeutic target and promising biomarker in tumors

miR-29 promotes osteosarcoma cell proliferation and migration by targeting PTEN

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