2020
DOI: 10.1093/jac/dkaa519
|View full text |Cite|
|
Sign up to set email alerts
|

Salmonella enterica serovar Typhi H58 clone has been endemic in Zimbabwe from 2012 to 2019

Abstract: Background Typhoid fever, caused by S. enterica ser. Typhi, continues to be a substantial health burden in developing countries. Little is known of the genotypic diversity of S. enterica ser. Typhi in Zimbabwe, but this is key for understanding the emergence and spread of this pathogen and devising interventions for its control. Objectives To report the molecular epidemiology of S. enterica ser. Typhi outbreak strains circula… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2
1

Citation Types

3
35
0

Year Published

2021
2021
2024
2024

Publication Types

Select...
8
1

Relationship

1
8

Authors

Journals

citations
Cited by 17 publications
(38 citation statements)
references
References 37 publications
3
35
0
Order By: Relevance
“…Overall, our data highlight that unlike other recently examined settings in Kenya, Zimbabwe and other regions of Sub-Saharan Africa, as well as South Asian settings in India, Nepal, Bangladesh and Pakistan [ 8 , 10 , 57 , 59 , 60 , 70 73 ] the S . Typhi populations in PNG appear sensitive to a diverse range of antimicrobials with former first line drugs, fluoroquinolones, third generation cephalosporins and macrolides all remaining viable treatment options prior to the introduction of Vi-conjugate vaccines and improvements to water, sanitation and hygiene (WaSH) related infrastructure.…”
Section: Discussionsupporting
confidence: 41%
“…Overall, our data highlight that unlike other recently examined settings in Kenya, Zimbabwe and other regions of Sub-Saharan Africa, as well as South Asian settings in India, Nepal, Bangladesh and Pakistan [ 8 , 10 , 57 , 59 , 60 , 70 73 ] the S . Typhi populations in PNG appear sensitive to a diverse range of antimicrobials with former first line drugs, fluoroquinolones, third generation cephalosporins and macrolides all remaining viable treatment options prior to the introduction of Vi-conjugate vaccines and improvements to water, sanitation and hygiene (WaSH) related infrastructure.…”
Section: Discussionsupporting
confidence: 41%
“…Overall, our data highlight that unlike other recently examined settings in Kenya, Zimbabwe and other regions of Sub-Saharan Africa, as well as South Asian settings in India, Nepal, Bangladesh and Pakistan [8,10,57,59,60,70–73] the S . Typhi populations in PNG appear sensitive to a diverse range of antimicrobials with former first line drugs, fluoroquinolones, third generation cephalosporins and macrolides all remaining viable treatment options prior to the introduction of Vi-conjugate vaccines and improvements to water, sanitation and hygiene (WaSH) related infrastructure.…”
Section: Discussionsupporting
confidence: 40%
“…The NCBI GenBank database presently contains over 12,500 full-size sequences of the species S. enterica . Numerous works on Salmonella genomes deal with the detection of genetic loci related to pathogenesis: antibiotic resistance genes, which are often located in integrons or transposons; Salmonella pathogenicity islands (SPI); and bacteriophages [ 13 , 14 , 15 , 16 ].…”
Section: Introductionmentioning
confidence: 99%