<i>Satureja hortensis</i> induces cell death and inhibited cell cycle progression in K562 myelogenous and Jurkat T cell leukemia cell lines

Asadipour, Morvarid; Amirghofran, Zahra

doi:10.1080/15321819.2019.1629592

Cited by 5 publications

(1 citation statement)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nowadays, the use of silver nanoparticles in the diagnosis and treatment of cancer-related diseases has attracted physicians, pharmacists, and researchers in these fields [50,51]. However, several articles have evaluated the anticancer effects of Satureja Species extract [52][53][54][55]. Nevertheless, there was no article or report on the effect of synthesized silver nanoparticles by Summer Savory on selected cancer cell lines.…”

Section: Cytotoxic Effect Of Ag Npsmentioning

confidence: 99%

Anti-bacterial/fungal and anti-cancer performance of green synthesized Ag nanoparticles using summer savory extract

Ahmadi

Fazilati

Mousavi

et al. 2020

Journal of Experimental Nanoscience

View full text Add to dashboard Cite

Nowadays, the expansion of nanoparticles as antimicrobial and anticancer agents is one of the most exciting methods for cancer therapy and microbial diseases that can vanquish the problems of drug resistance. In this research, the biosynthesis of silver nanoparticles (AgNPs) was stated using Summer Savory extract. Moreover, these AgNPs by UV-Vis spectroscopy, FTIR, XRD, FESEM, EDX, PSA, and zeta potential analysis were characterized, and by antimicrobial and anti-cancerous performance was evaluated. The maximum absorption peak at 472 nm by UV-Visible spectra confirmed the formation of Ag nanoparticles. The results obtained by FT-IR determined the presence of organic compounds such as amines, alkenes, alcohols, phenols, which performed significant roles in the fixating of these nanoparticles. The results obtained from FESEM, EDX, PSA, and Zeta Potential Analysis revealed that synthesized AgNPs had a hexagonal structure with a size ranging from 10 to 100 nm. The antimicrobial properties of the synthesized AgNPs were examined by Minimum Inhibitory Concentration, Minimum Bactericidal Concentration, and Minimum Fungal Concentration against five microbial strains included Klebsiella pneumonia, Escherichia coli, Enterococcus faecalis, Staphylococcus aureus, and Saccharomyces cerevisiae. The results demonstrated that biosynthesized AgNPs had the most antimicrobial activity, especially against E. Coli. The anti-cancerous results of these nanoparticles through MTT assay demonstrated exceptional anticancer effects against K-562 and MCF-7 human cancer cell lines with IC50 values 50 and 200 mg/ml, respectively.

show abstract