<scp>ADIPOQ</scp>,<scp>KCNJ</scp>11 and <scp>TCF</scp>7L2 polymorphisms in type 2 diabetes in Kyrgyz population: A case‐control study

Isakova, Jainagul; Talaibekova, Elnura; Vinnikov, Denis; Saadanov, Iskender; Aldasheva, Nazira

doi:10.1111/jcmm.14061

Cited by 15 publications

(11 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Substantial evidence demonstrate that T2DM can be attributed by lifestyle, environmental and genetic factors [5][6][7][8]. Although the etiology of T2DM is complex and needs further study, genetic factors have been identified to be an important cause, and an increasing number of candidate genes have been identified recent years [9,10]. Thus, investigating the candidate genes involved in the onset and development of T2DM may shed light on the molecular mechanisms underlying the disease.…”

Section: Introductionmentioning

confidence: 99%

Association ofIL-16gene polymorphisms with the risk of developing type 2 diabetes mellitus in the Chinese Han population

et al. 2019

View full text Add to dashboard Cite

Objective: The aim of the present study was to explore the genetic association of single nucleotide polymorphisms (SNPs) in interleukin-16 (IL-16) gene with type 2 diabetes mellitus (T2DM) susceptibility in a Chinese Han population. Methods: In total, 133 T2DM patients and 127 healthy controls matched by age and gender were recruited in the case–control study. IL-16 gene rs4778889 and rs11556218 polymorphisms were genotyped in the two groups via polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Differences in genotype and allele distributions between groups were compared by the χ2 test. All the comparisons were adjusted for age, gender, and body mass index (BMI) by logistic regression. The odds ratios (ORs) and 95% confidence intervals (CIs) were used to evaluate the association strength between IL-16 gene polymorphism and T2DM risk. Results: The TG genotype and G allele frequencies of rs11556218 increased remarkably in the case group than that in controls (45.86 vs 33.86%; 29.70 vs 20.87%), and the differences reached a significant level (P<0.05). After adjusting for age, gender, and BMI, the differences still reached a significant level (P<0.05). Rs11556218 TG genotype carriers had a 1.769-fold increased risk of developing T2DM (OR = 1.769, 95% CI = 1.045–2.994), and G allele was also associated with an increased risk of T2DM (OR = 1.639, 95% CI = 1.087–2.471). IL-16 rs4778889 polymorphism showed no significant association with T2DM risk. Conclusion: IL-16 gene rs11556218 polymorphism was significantly associated with T2DM susceptibility in the Chinese Han population, while rs4778889 was not.

show abstract

Section: Introductionmentioning

confidence: 99%

Association ofIL-16gene polymorphisms with the risk of developing type 2 diabetes mellitus in the Chinese Han population

et al. 2019

View full text Add to dashboard Cite

show abstract

“…The data did not conform to the HWE test, and hence, these studies were excluded. In the Kyrgyz population [ 80 ], a correlation was established between the allele and heterozygous genotype of rs1501299 and T2DM. However, limited statistical data and inconformity with the HWE test led to the exclusion of this study.…”

Section: Discussionmentioning

confidence: 99%

Meta-analysis of the association between adiponectin SNP 45, SNP 276, and type 2 diabetes mellitus

et al. 2020

View full text Add to dashboard Cite

Objective The present study aimed to determine whether the polymorphisms at rs2241766 and rs1501299 on the ADIPOQ gene were related to the susceptibility of type 2 diabetes mellitus (T2DM). Methods Eight databases, PubMed, GWAS, Embase, Lochrane, Ebsco, CNKI (Chinese National Knowledge Infrastructure), VIP (Viper Database) and ChinaInfo were searched, and a meta-analysis of susceptibility was conducted between SNP45, SNP276 polymorphisms and T2DM. Furthermore, HWE test was conducted to assess the genetic balance of the study, evaluate the quality of Newcastle–Ottawa quality assessment scale (NOS), and establishing allelic, dominant, recessive, heterozygous, and homozygous gene models. Results This meta-analysis included 53 articles, encompassing 9285 cases with rs2241766 and 14156 controls and 7747 cases with rs1501299 and 10607 controls. For the rs2241766 locus, a significant correlation was found in the three models by the subgroup analysis. Western Asians: dominant gene model (TT + TG vs. GG, P = 0.01); heterozygous gene model (TG vs. GG, P = 0.02); homozygous gene model (TT vs. GG, P = 0.01). South Asians: dominant gene model (TT + TG vs. GG, P = 0.004); heterozygous gene model (TG vs. GG, P = 0.009); homozygous gene model (TT vs. GG, P = 0.005). However, no statistically significant correlation was established among the five genetic models for rs1501299 locus. Conclusion The findings of the present study indicated that the T allele of rs2241766 polymorphism is the susceptibility locus of T2DM in the West Asian population, but has a protective effect in the South Asian population, albeit further studies are needed in other populations. Also, no association was found between the ADIPOQ rs1501299 polymorphism and T2DM.

show abstract

“…There are varying reports of the association between T2DM and the rs5219 and rs5210 genotypes in KCNJ11 in different populations [11,[32][33][34][35][36][37][38][39]. Moreover, this association has yielded different results in the same population as well.…”

Section: Kcnj11 Kcnq1mentioning

confidence: 99%

Identifying the association between single nucleotide polymorphisms in KCNQ1, ARAP1, and KCNJ11 and type 2 diabetes mellitus in a Chinese population

Shen

et al. 2020

Int. J. Med. Sci.

View full text Add to dashboard Cite

Background: Type 2 diabetes mellitus (T2DM) has a high global prevalence, and insufficient insulin secretion is one of the major reasons for its development. Therefore, investigating the association between T2DM and the single nucleotide polymorphisms (SNPs) in genes associated with insulin secretion is necessary. Methods: T2DM (1,194) and nondiabetic (NDM) (1,292) subjects were enrolled and the ten single nucleotide polymorphisms (SNPs) in KCNQ1, ARAP1, and KCNJ11 associated with insulin secretion were genotyped in a Chinese population. Results: Our data revealed that the rs2237897T allele in KCNQ1 is the protective allele for T2DM (P<0.001, OR=0.793; 95%CI: 0.705-0.893). However, the A allele of rs1552224 in ARAP1 may be a risk factor for T2DM (P=0.002, OR=12.070; 95% CI: 1.578-92.337). The haplotype analysis revealed that rs151290-rs2237892CC and rs2237895-rs2237897CC in KCNQ1 constitute the risk haplotype in T2DM development (P=0.010, OR=1.160; 95% CI: 1.037-1.299 and P=0.004, OR=1.192; 95% CI: 1.057-1.344). Moreover, rs2237895-rs2237897AT in KCNQ1 constitutes the protective haplotype in T2DM (P=0.001, OR=0.819; 95%

show abstract

ADIPOQ,KCNJ11 and TCF7L2 polymorphisms in type 2 diabetes in Kyrgyz population: A case‐control study

Cited by 15 publications

References 13 publications

Association ofIL-16gene polymorphisms with the risk of developing type 2 diabetes mellitus in the Chinese Han population

Association ofIL-16gene polymorphisms with the risk of developing type 2 diabetes mellitus in the Chinese Han population

Meta-analysis of the association between adiponectin SNP 45, SNP 276, and type 2 diabetes mellitus

Identifying the association between single nucleotide polymorphisms in KCNQ1, ARAP1, and KCNJ11 and type 2 diabetes mellitus in a Chinese population

Contact Info

Product

Resources

About