IAP-Mediated Protein Ubiquitination in Regulating Cell Signaling

Dumetier, Baptiste; Zadoroznyj, Aymeric; Dubrez, Laurence

doi:10.3390/cells9051118

Cited by 38 publications

(30 citation statements)

References 201 publications

(318 reference statements)

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“…Therefore, keeping the activation of the caspase cascade under control is of vital importance for organisms. IAPs protect cells against massive apoptotic cell death by inhibiting caspases, and their conserved homologs are found in many taxa, such as fungi, vertebrates and invertebrates [36,37]. The upregulation of IAP proteins is associated with cell survival; thus, IAP members are considered as a resistance marker of cancer treatment and, moreover, apoptotic resistance can break down via downregulation of IAPs [38,39].…”

Section: Discussionmentioning

confidence: 99%

Effects of hypoxia on the mRNA expressions of TRAIL-mediated cell death related genes in hypoxia-tolerant rodent (Nannospalax nehringi) and some characteristics of these proteins

Yildiz

Kamiloğlu

Öziç

et al. 2021

ARCH BIOL SCI BELGRA

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The aim of the present study was to determine the mRNA expression profiles of TRAILmediated cell death related genes of the hypoxia-tolerant rodent Nannospalax nehringi under hypoxia. The nucleotide and amino acid sequences of these genes were identified. Captured Nannospalax nehringi were randomly divided into normoxia and hypoxia groups. The hypoxia group was exposed to a 7% O2 + 93% N2 gas mixture for 52 h, while animals in the normoxia group were housed under normoxic conditions. Total RNAs were isolated from brain and lung tissues. The cIAP-1, cIAP-2, XIAP, DcR1, DcR2, FLIP and OPG genes were PCR amplified, and the cIAP-1, cIAP-2, XIAP, OPG, TRAIL and FLIP genes were sequenced. Sequenced genes were translated into amino acid sequences and compared with reliable sequences of closely similar species. The genes in the brain were regulated for protection against hypoxia; however, the genes in the lung were regulated differently. Many mutations and insertions were observed on the conserved regions of the cIAP-1, cIAP-2, XIAP, OPG and TRAIL genes in N. nehringi. We propose that these gene mutations and insertions contribute to the anti-hypoxic properties of N. nehringi.

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Section: Discussionmentioning

confidence: 99%

Effects of hypoxia on the mRNA expressions of TRAIL-mediated cell death related genes in hypoxia-tolerant rodent (Nannospalax nehringi) and some characteristics of these proteins

Yildiz

Kamiloğlu

Öziç

et al. 2021

ARCH BIOL SCI BELGRA

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“…This implies the presence of accurate regulation mechanisms. In addition to promote the production of microbicidal molecules and pro-inflammatory mediators, TLR-mediated NF-κB activation induces the expression of several survival proteins such as cellular inhibitors of apoptosis (cIAPs) ( 146 ). cIAPs act as E3-ubiquitin ligases promoting poly-ubiquitination of RIP1.…”

Section: Cell Death Regulations In Mammals and Plantsmentioning

confidence: 99%

“…When polyubiquitinated RIP1 and -2 function as a molecular scaffold. It promotes the recruitment and the activation of the kinase complexes IKK and TAB1/TAB2/TAK1 that promote a pro-survival and pro-inflammatory response ( Figure 2 ) ( 146 , 160 , 161 ). On the other hand the non-degradative ubiquitination also completely inhibits RIP1 kinase activity that is essential for the assembly of secondary cytoplasmic cell death signaling platforms leading to apoptosis or necroptosis ( 18 , 160 ).…”

Section: Cell Death Regulations In Mammals and Plantsmentioning

confidence: 99%

Cross Kingdom Immunity: The Role of Immune Receptors and Downstream Signaling in Animal and Plant Cell Death

et al. 2021

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Both plants and animals are endowed with sophisticated innate immune systems to combat microbial attack. In these multicellular eukaryotes, innate immunity implies the presence of cell surface receptors and intracellular receptors able to detect danger signal referred as damage-associated molecular patterns (DAMPs) and pathogen-associated molecular patterns (PAMPs). Membrane-associated pattern recognition receptors (PRRs), such as Toll-like receptors (TLRs), C-type lectin receptors (CLRs), receptor-like kinases (RLKs), and receptor-like proteins (RLPs) are employed by these organisms for sensing different invasion patterns before triggering antimicrobial defenses that can be associated with a form of regulated cell death. Intracellularly, animals nucleotide-binding and oligomerization domain (NOD)-like receptors or plants nucleotide-binding domain (NBD)-containing leucine rich repeats (NLRs) immune receptors likely detect effectors injected into the host cell by the pathogen to hijack the immune signaling cascade. Interestingly, during the co-evolution between the hosts and their invaders, key cross-kingdom cell death-signaling macromolecular NLR-complexes have been selected, such as the inflammasome in mammals and the recently discovered resistosome in plants. In both cases, a regulated cell death located at the site of infection constitutes a very effective mean for blocking the pathogen spread and protecting the whole organism from invasion. This review aims to describe the immune mechanisms in animals and plants, mainly focusing on cell death signaling pathways, in order to highlight recent advances that could be used on one side or the other to identify the missing signaling elements between the perception of the invasion pattern by immune receptors, the induction of defenses or the transmission of danger signals to other cells. Although knowledge of plant immunity is less advanced, these organisms have certain advantages allowing easier identification of signaling events, regulators and executors of cell death, which could then be exploited directly for crop protection purposes or by analogy for medical research.

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“…They do this through direct antagonism, ubiquitination, and neddylation of apoptosis caspases [ 225 , 226 ], and ubiquitination of BECN1 (reducing autophagy) and RIPK1 [ 227 ], suppressing its aberrant activation. RIPK1 is a death domain containing protein that controls differentiation and inflammation transcriptional responses [ 228 ]. The scaffolding function of RIPK1 is essential to promote pro-survival NF-κB signalling through the assembly of complex I, while activation of RIPK1 leads to either apoptosis or necroptosis [ 229 ].…”

Section: Autophagy As Part Of a Hiv-1 Cure Approachmentioning

confidence: 99%

Induction of Autophagy to Achieve a Human Immunodeficiency Virus Type 1 Cure

Campbell

Spector

2021

Cells

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Effective antiretroviral therapy has led to significant human immunodeficiency virus type 1 (HIV-1) suppression and improvement in immune function. However, the persistence of integrated proviral DNA in latently infected reservoir cells, which drive viral rebound post-interruption of antiretroviral therapy, remains the major roadblock to a cure. Therefore, the targeted elimination or permanent silencing of this latently infected reservoir is a major focus of HIV-1 research. The most studied approach in the development of a cure is the activation of HIV-1 expression to expose latently infected cells for immune clearance while inducing HIV-1 cytotoxicity—the “kick and kill” approach. However, the complex and highly heterogeneous nature of the latent reservoir, combined with the failure of clinical trials to reduce the reservoir size casts doubt on the feasibility of this approach. This concern that total elimination of HIV-1 from the body may not be possible has led to increased emphasis on a “functional cure” where the virus remains but is unable to reactivate which presents the challenge of permanently silencing transcription of HIV-1 for prolonged drug-free remission—a “block and lock” approach. In this review, we discuss the interaction of HIV-1 and autophagy, and the exploitation of autophagy to kill selectively HIV-1 latently infected cells as part of a cure strategy. The cure strategy proposed has the advantage of significantly decreasing the size of the HIV-1 reservoir that can contribute to a functional cure and when optimised has the potential to eradicate completely HIV-1.

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IAP-Mediated Protein Ubiquitination in Regulating Cell Signaling

Cited by 38 publications

References 201 publications

Effects of hypoxia on the mRNA expressions of TRAIL-mediated cell death related genes in hypoxia-tolerant rodent (Nannospalax nehringi) and some characteristics of these proteins

Effects of hypoxia on the mRNA expressions of TRAIL-mediated cell death related genes in hypoxia-tolerant rodent (Nannospalax nehringi) and some characteristics of these proteins

Cross Kingdom Immunity: The Role of Immune Receptors and Downstream Signaling in Animal and Plant Cell Death

Induction of Autophagy to Achieve a Human Immunodeficiency Virus Type 1 Cure

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