2021
DOI: 10.3390/ijms221810078
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IAPV-Induced Paralytic Symptoms Associated with Tachypnea via Impaired Tracheal System Function

Abstract: Although it had been reported that Israeli acute paralysis virus (IAPV) can cause systemic infection in honey bees, little is known about how it establishes this infection and results in the typical symptoms, paralysis and trembling. Here, we used our previously constructed IAPV infectious clone to investigate viral loads in different tissues of honey bees and further identify the relation between tissue tropism and paralytic symptoms. Our results showed that tracheae showed a greater concentration of viral ab… Show more

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Cited by 4 publications
(4 citation statements)
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“…Aggregation in the hypopharyngeal glands can be strategic for the virus to spread from one host to another, but aggregation in nerves suggests potential neural alterations causing trembling and paralysis. In contrast, other authors [ 218 ] have found viral particles to accumulate mostly in the fat body and trachea. Evidence of mitochondrial respiratory disruption in tracheal cells caused by the viral invasion may be the actual cause of the symptoms and abrupt death following AKI infection.…”
Section: Viral Interactionsmentioning
confidence: 65%
“…Aggregation in the hypopharyngeal glands can be strategic for the virus to spread from one host to another, but aggregation in nerves suggests potential neural alterations causing trembling and paralysis. In contrast, other authors [ 218 ] have found viral particles to accumulate mostly in the fat body and trachea. Evidence of mitochondrial respiratory disruption in tracheal cells caused by the viral invasion may be the actual cause of the symptoms and abrupt death following AKI infection.…”
Section: Viral Interactionsmentioning
confidence: 65%
“…Damage to the honey bee trachea due to IAPV infection has been reported to cause paralysis, indicating a direct causal relationship between paralysis and tissue tropism. This finding has provided new insights into understanding the underlying mechanism of paralysis symptoms in honey bees following viral infection and has implications for viral disease prevention and specific therapeutics in practice [19,20]. The use of the RT-PCR method as a sensitive, rapid, and specific method for diagnosing IAPV infection showed that the spread of the virus in different regions can be influenced by geographical conditions as well as by the density of bee colonies.…”
Section: Resultsmentioning
confidence: 96%
“…IAPV covert infection induces a broad spectrum of clinical signs including paralysis and body trembling. However, whether the neuron system is the preferred tropism of the virus has not yet been resolved [ 386 ]. In a study conducted to investigate viral abundance in different tissues of honeybees, the tracheae showed a greater viral load than other tissues.…”
Section: Description Of Main Bee Pathogens and Molecular Methods For ...mentioning
confidence: 99%
“…In addition, large quantities of virus in tracheae induced a notorious downregulation of succinate dehydrogenase and cytochrome c oxidase genes. The authors concluded that paralytic signs or trembling mitigated tachypnea induced by IAPV infection [ 386 ].…”
Section: Description Of Main Bee Pathogens and Molecular Methods For ...mentioning
confidence: 99%