ICP Spectrometric–Vis Separation of Cerium (IV)–Desferal Complex Using 4- Vinylbenzyl-Dimethylammonio Pentanesulfonate Zwitterionic Stationary Phase

An easy, simple and ecofriendly process for the estimation of moxifloxacin (MFN) in the pharmaceutical samples, serum and blood. The prepared sensors contained moxifloxacin–bromophenol blue as ionphore and, tris(2-ethylhexyl) phosphate, di-butyl phthalate and di-butyl phosphate as plasticizers. The electrodes based on di-n-butyl phthalate (DBPH), Tris (2-ethylhexyl) phosphate (TEHP), and di-butyl phosphate (DBP), gave slope 44.50, 56.86 and 46.38 mV/decade, respectively. The linear concentrations were 1×10-5 - 1×10-2, 5×10-5- 1×10-2 and 5×10-5 - 1×10-2 M with detection limits of 9.0×10-6, 4.7×10-5 and 4.9×10-5 M and a lifetime of 17, 39 and 12 days for electrodes based on DBPH, TEHP, and DBP, respectively. The best electrode was TEHP which gave the best results. The sensor that based on TEHP as plasticizer was better response and stability, it was used to estimate the moxifloxacin in pharmaceutical samples using single and multi-standard addition potentiometry.

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“…S was the slope value of the calibration curve and ∆E was the change in the potential of the electrode. 21,22…”

Section: Analytical Techniquesmentioning

confidence: 99%

Novel Potentiometric Sensor for Estimation of the Moxifloxacin in the Pharmaceutical Samples, Urine, and Serum

Abrahem¹,

Ahmad²,

Al-Phalahy³

2022

IJDDT

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“…In recent years, HILIC separation has clearly been employed in a broad variety of applications, as seen by the abundance of research that have been published on the topic. Rashid and his coworkers presented some of the investigations that has been listed in [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20].…”

Section: Introductionmentioning

confidence: 99%

High-Performance Liquid Chromatography (HPLC): Primary Mechanism and Popular Applications

Radi Karabat,

Jasim Hammood,

Abdulhusein Abdulrasool

et al. 2023

ANJS

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The concept chromatography can be used to refer to a huge variety of distinct analytical procedures. Each of these procedures utilizes a mobile phase and an immobile phase as a basic component, yet they all belong under the chromatography umbrella concept. The subsequent component separation that is carried out is based on the disparity in concentration ratio that can be detected between the two phases. This disparity acts as the basis for the subsequent component separation that is carried out. Due to the limits of current technology, there is presently no detector that is universally applicable to high-performance liquid chromatography (HPLC), it is required to choose a detector in accordance with the characteristics of the chemicals that are to be examined. The measurements of absorbance in ultraviolet and visible spectrum, known as UV-Vis, or disclosing fluorescence are the foundations of the most common types of fluorescence detectors. In HPLC the components of the apparatus consist of a carrier phase, which is typically a solvent with a buffer solution; a pump; an injector; a column; a detector; and an integrator. The column is the most important part of the system where the various components are separated from one another. Based on that, there are many various kinds of columns through which the behavior of the components to be separated by these columns is understood. Due to the fact that chromatography is such a widely used technology.

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“…Hydrophilic and polar compounds, as compared to hydrophobic neutral compounds, are retained preferentially in HILIC the contrary of RP-HPLC. Thus recently, HILIC technology has thus recently begun to increase dramatically in the estimation of drugs, nucleosides, carboxylic acids, inorganic ions, and amino acids by Rasheed and its co-workers [24][25][26][27][28][29][30][31][32][33][34]. Experimental…”

Section: Introductionmentioning

confidence: 99%

Development of a validated hydrophilic interaction chromatography method for the determination of cefotaxime in pharmaceutical preparations

Kzar¹,

Rasheed

Hassan

2021

Egypt. J. Chem.

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Cefotaxime is considered as one of the semi-synthetic, 3rd generation, cephalosporin antibiotics that have been utilized for treating a lot of infections resulting from different organisms. The technique of hydrophilic chromatography interaction (HILIC) has increased the accuracy and sensitivity concerning other methods, particularly spectrophotometer. The objective of this article was to introduce a simple method for the estimation of cefotaxime in pure and pharmaceutical injection forms and study the separation mechanism of cefotaxime. HILIC mode achieved excellent separation under chromatographic conditions on a HALO ® HILIC 2.7 column (100 mm x 2.1 mm I.D.) at 35 ° C with the following conditions: 10:90% acetate buffer (pH 5.5-40 mM): acetonitrile as eluent and wavelength of detection 254 nm. The proposed HILIC method exhibited high precision (RSD% < 0.5%), concentration ranges of 100-5500 ppb, and the lowest detection limit was 6.8167 ppb with a coefficient of determination of 0.9998 for cefotaxime. The findings of the method were used statistical tests compared to the British Pharmacopoeia protocol, which did not show any difference in accuracy among the methods

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ICP Spectrometric–Vis Separation of Cerium (IV)–Desferal Complex Using 4- Vinylbenzyl-Dimethylammonio Pentanesulfonate Zwitterionic Stationary Phase

Cited by 7 publications

References 0 publications

Novel Potentiometric Sensor for Estimation of the Moxifloxacin in the Pharmaceutical Samples, Urine, and Serum

Novel Potentiometric Sensor for Estimation of the Moxifloxacin in the Pharmaceutical Samples, Urine, and Serum

High-Performance Liquid Chromatography (HPLC): Primary Mechanism and Popular Applications

Development of a validated hydrophilic interaction chromatography method for the determination of cefotaxime in pharmaceutical preparations

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