2018
DOI: 10.1101/358358
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Identification and characterisation of serotonin signalling in the potato cyst nematodeGlobodera pallidareveals new targets for crop protection

Abstract: Plant parasitic nematodes are microscopic pests that invade plant roots and cause extensive damage to crops worldwide. To investigate mechanisms underpinning their parasitic behaviour we used a chemical biology approach: We discovered that reserpine, a plant alkaloid known for its antagonism of the mammalian vesicular monoamine transporter VMAT and ability to impart a global depletion of synaptic biogenic amines in the nervous system, potently impairs the ability of the potato cyst nematode Globodera pallida t… Show more

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Cited by 3 publications
(8 citation statements)
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“…23 For example, serotonin a known activator of stylet thrusting elicited a concentrationand time-dependent stylet thrusting, which reached a plateau at a high concentration. 23,24 Similarly, in the chemotaxis assays, attractiveness of J2s to the root exudate was concentrationdependent and significantly higher (77.2%; χ 2 = 26.1; df = 1; and p < 0.001) than the negative control. For instance, at 10 μg/g of sand, the attractiveness of the root exudate compared favorably to the positive control, MeSA, at 20 ng/g of sand (73.4%; χ 2 = 21.94; df = 1; and p < 0.001) (Figure 3B).…”
Section: ■ Materials and Methodsmentioning
confidence: 90%
“…23 For example, serotonin a known activator of stylet thrusting elicited a concentrationand time-dependent stylet thrusting, which reached a plateau at a high concentration. 23,24 Similarly, in the chemotaxis assays, attractiveness of J2s to the root exudate was concentrationdependent and significantly higher (77.2%; χ 2 = 26.1; df = 1; and p < 0.001) than the negative control. For instance, at 10 μg/g of sand, the attractiveness of the root exudate compared favorably to the positive control, MeSA, at 20 ng/g of sand (73.4%; χ 2 = 21.94; df = 1; and p < 0.001) (Figure 3B).…”
Section: ■ Materials and Methodsmentioning
confidence: 90%
“…A search of transcriptome data for the filarial nematode parasite Loa loa, Brugia malayi, and Wucheria bancrofti revealed predicted coding sequences for orthologs of mod-1 gene (17). MOD-1 is also present in plant parasitic nematodes, in which serotonergic signaling is important for plant invasion (18).…”
Section: J O U R N a L P R E -P R O O Fmentioning
confidence: 99%
“…Serotonin also functions in the feeding behavior of plant pathogenic nematodes with a stylet to penetrate host plant roots. Reserpine, an antagonist of the vesicular monoamine transporter, inhibits movement of the stylet on the pharynx in potato cyst nematodes, Globodera pallida (Crisford et al, 2018). Taken together, serotonin is involved in the regulation of feeding behavior in a wide range of nematodes, even though these nematodes have different mouth structures and feeding habits from those of C. elegans.…”
Section: Serotonin Receptors and Downstream Circuitsmentioning
confidence: 99%
“…Further studies on this system may contribute to studies on neuromodulation in higher animals, offering insights into the neural modulatory circuit mediating environmental input from sensory neurons and outputs to muscle movements. (Rivard et al, 2010) and (Van Megen et al, 2009), and serotonergic neurons are based on (Chiang et al, 2006;Crisford et al, 2018;Johnson et al, 1996;Rao et al, 2011;Rivard et al, 2010;Weeks et al, 2016;Wilecki et al, 2015) Fig. 5.…”
Section: Serotonin Receptors and Downstream Circuitsmentioning
confidence: 99%
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