Identification and characterization of Methyl succinate from Bacillus velezensis AR1

Regassa, Ayana Bayisa; Cho, Jeong Yong; Kim, Kil Yong

doi:10.1007/s13313-020-00701-z

Cited by 4 publications

(2 citation statements)

References 18 publications

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“…Bacillus velezensis AR1 produces a number of secondary metabolites and extracellular enzymes. For instance, AR1 produced monomethyl succinate in the culture broth extracted with ethyl acetate 13 and catalytic chitinase and 1.3 β‐glucanase enzymes 8 . AR1 demonstrated strong antifungal activity and effective induction of Sesame indicum (sesame) systemic resistance against Alternaria sesame 14 .…”

Section: Discussionmentioning

confidence: 99%

Purification and identification of a new antifungal dipeptide from Bacillus velezensis AR1 culture supernatant

Bayisa¹,

Cho

Kim

2020

Pest Management Science

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BACKGROUND Bacillus velezensis and other Bacillus species are known for the production of bioactive secondary metabolites that are active against plant pathogenic fungi. In view of this, a study was undertaken to investigate the antifungal potential of B. velezensis AR1 culture supernatant. RESULT The butanol extract concentrate of B. velezensis AR1 was separated into different fractions by column chromatography. A fraction eluted by 9:1 chloroform: methanol caused 25.8–70.2% and 25.2–56.3% growth inhibition of Monilinia fructicola and Colletotricum goeosporioides, respectively. This fraction was subjected to solid‐phase extraction using a Strata SI‐1 column and further purified by prep‐TLC to obtain a pure metabolite showing a single peak on high performance liquid chromatography. On the basis of the nuclear magnetic resonance (NMR 1H, 13C, HH COSY, HSQC and HMBC) analysis, the metabolite was identified as 5‐N‐tyrosinylornithine. The compound exhibited antifungal activity against two plant pathogenic fungi. CONCLUSION 5‐N‐tyrosinylornithine, the secondary metabolite isolated from the culture supernatant of B. velezensis AR1 exhibited significant antifungal activity against two plant pathogenic fungi.

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Section: Discussionmentioning

confidence: 99%

Purification and identification of a new antifungal dipeptide from Bacillus velezensis AR1 culture supernatant

Bayisa¹,

Cho

Kim

2020

Pest Management Science

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“…The complexity of column chromatography showed the complexity of the substances in crude toxin extraction. The target active substances can be selectively separated and eluted by gradient elution (El-Hasan et al 2009;Regassa et al 2020). The liquid-solid chromatography method was used to explore the conditions of HPLC (Sidana and Joshi 2013).…”

Section: Verification Of Monomer Activitiesmentioning

confidence: 99%

Identification and extraction of herbicidal compounds from metabolites of Trichoderma polysporum HZ-31

Zhu

Chen

et al. 2022

Weed Sci

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The Trichoderma polysporum HZ-31 fermentation broth was separated and purified by extraction, column chromatography and high-phase liquid chromatography. Four monomer compounds with strong herbicidal activity were obtained: p-hydroxyphenyl-2,3-dihydroxypropyl ether, o-hydroxy-3-carbonyl-1-phenylpropanol, 1,8-propanediol o-xylene and 2-3-dihydroxypropyl propionate. The biological activity verification test indicated that the four monomer compounds could inhibit the germination of wild oat (Avena fatua L.) and canola (Brassica napus L.) seeds. Of the four, compound 3 (1,8-propanediol o-xylene) had obvious inhibitory effects on the germination of A. fatua and B. napus seeds, with inhibition rates of 83.33% and 86.67%, respectively. Therefore, the identification of this monomer compound lays a foundation for the further development of a novel microbial herbicide by directly utilizing it and developing new derivatives with herbicidal functions as lead compounds.

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Antifungal compound, methyl hippurate from Bacillus velezensis CE 100 and its inhibitory effect on growth of Botrytis cinerea

Maung

Lee

Cho

et al. 2021

World J Microbiol Biotechnol

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Identification and characterization of Methyl succinate from Bacillus velezensis AR1

Cited by 4 publications

References 18 publications

Purification and identification of a new antifungal dipeptide from Bacillus velezensis AR1 culture supernatant

Purification and identification of a new antifungal dipeptide from Bacillus velezensis AR1 culture supernatant

Identification and extraction of herbicidal compounds from metabolites of Trichoderma polysporum HZ-31

Antifungal compound, methyl hippurate from Bacillus velezensis CE 100 and its inhibitory effect on growth of Botrytis cinerea

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