Identification and evaluation of anti-inflammatory properties of aqueous components extracted from sesame ( Sesamum indicum ) oil

Deme, Pragney; Narasimhulu, Chandrakala Aluganti; Parthasarathy, S.

doi:10.1016/j.jchromb.2018.04.029

Cited by 33 publications

(18 citation statements)

References 61 publications

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“…The extent of the effect of other sesame extracts on the inflammatory cytokines and mediators has also been investigated thoroughly. One study involves the aqueous extract of sesame oil (SOAE) [114], which has twenty-eight identified molecules that ranges from moderate to polar in nature. The SOAE-methoxyphenol derivatives (SOAE-8; i.e., vanillyl alcohol, p-hydroxyphenylacetic acid, vanillic acid, coniferyl alcohol, p-coumaric acid, ferulic acid, sinapic acid and syringic acid) are the key components for its anti-inflammatory property.…”

Section: Lung Diseasementioning

confidence: 99%

Anti-Inflammatory and Anticancer Properties of Bioactive Compounds from Sesamum indicum L.—A Review

Aquino

Barbaza

et al. 2019

Molecules

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The use of foodstuff as natural medicines has already been established through studies demonstrating the pharmacological activities that they exhibit. Knowing the nutritional and pharmacological significance of foods enables the understanding of their role against several diseases. Among the foods that can potentially be considered as medicine, is sesame or Sesamum indicum L., which is part of the Pedaliaceae family and is composed of its lignans such as sesamin, sesamol, sesaminol and sesamolin. Its lignans have been widely studied and are known to possess antiaging, anticancer, antidiabetes, anti-inflammatory and antioxidant properties. Modern chronic diseases, which can transform into clinical diseases, are potential targets of these lignans. The prime example of chronic diseases is rheumatic inflammatory diseases, which affect the support structures and the organs of the body and can also develop into malignancies. In line with this, studies emphasizing the anti-inflammatory and anticancer activities of sesame have been discussed in this review.

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Section: Lung Diseasementioning

confidence: 99%

Anti-Inflammatory and Anticancer Properties of Bioactive Compounds from Sesamum indicum L.—A Review

Aquino

Barbaza

et al. 2019

Molecules

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“…Later, Ismail, Hasan, El‐Orfali, Ismail, and Khawaja () reported that daily oral administration of Δ9‐THC/SO combination, over a period of 21 days, attenuated erythrocyte sedimentation rate scores and proinflammatory cytokines, including TNF‐α, IL‐1β, and IL‐6 levels, to normal values and MTX‐treated values on adjuvant‐induced arthritis rat model (Ismail et al, ). Some in vitro studies also showed that SO has potent antiinflammatory properties by downregulating inflammatory markers as seen with LPS‐induced inflammation in RAW macrophages or mouse peritoneal macrophages (Deme, Narasimhulu, & Parthasarathy, ; Narasimhulu, Burge, Doomra, Riad, & Parthasarathy, ; Selvarajan, Narasimhulu, Bapputty, & Parthasarathy, ). The atherosclerosis polymerase chain reaction (PCR) array revealed downregulation of a number of inflammatory markers such as Ccl2 or MCP‐1, Ccl5 or RANTES, IL‐1α, IL‐1β, and TNF in the presence of SO (Selvarajan et al, ).…”

Section: Resultsmentioning

confidence: 99%

A systematic review on antioxidant and antiinflammatory activity of Sesame (Sesamum indicum L.) oil and further confirmation of antiinflammatory activity by chemical profiling and molecular docking

Afroz

Zihad

Uddin

et al. 2019

Phytotherapy Research

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Traditionally, sesame oil (SO) has been used as a popular food and medicine. The review aims to summarize the antioxidant and antiinflammatory effects of SO and its identified compounds as well as further fatty acid profiling and molecular docking study to correlate the interaction of its identified constituents with cyclooxygenase-2 (COX-2). For this, a literature study was made using Google Scholar, Pubmed, and SciFinder databases. Literature study demonstrated that SO has potential antioxidant and antiinflammatory effects in various test systems, including humans, animals, and cultured cells through various pathways such as inhibition of COX, nonenzymatic defense mechanism, inhibition of proinflammatory cytokines, NF-kB or mitogenactivated protein kinase signaling, and prostaglandin synthesis pathway. Fatty acid analysis of SO using gas chromatography identified known nine fatty acids. In silico study revealed that sesamin, sesaminol, sesamolin, stigmasterol, Δ5-avenasterol, and Δ7-avenasterol (−9.6 to −10.7 kcal/mol) were the most efficient ligand for interaction and binding with COX-2. The known fatty acid also showed binding efficiency with COX-2 to some extent (−6.0 to −8.4 kcal/mol). In summary, it is evident that SO may be one of promising traditional medicines that we could use in the prevention and management of diseases associated with oxidative stress and inflammation.

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“…Based on comparing full scan mass spectra, parent ions, and MS/MS fragment ions data with those in a related database, a total of 14 compounds belonging to phenolic acids and flavonoids were identified in the extract ( Table 1 ). These predominant compounds found in Std-AM, such as 3-methoxysalicylic acid, baicalein, kaempferol, luteolin, naringenin, and apigenin, have previously been reported to have remarkable anti-inflammatory effects due, in part, to their inhibitory action on NF- κ B signaling pathways 20 , 21 . Std-AM presented a concentration of total phenolic compounds of 80.02 ± 7.87 GAE mg/g measured using Folin-Ciocalteuʼs colorimetric method.…”

Section: Resultsmentioning

confidence: 99%

The Standardized Wood Extract of Albizia myriophylla: Its Potential as an Active Ingredient in an Anti-inflammatory Herbal Gel Formulation

et al. 2021

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Albizia myriophylla has been used in Thai folk medicine for treating inflammation-related diseases. The wood of this medicinal plant is traditionally used as a single herbal drug in the form of an aqueous decoction and as a component in several Thai herbal formulations for the remedy of fever, sore throat, and aphthous ulcers. This study aimed to evaluate in vivo the anti-inflammatory potential and possible mechanism of action of the standardized wood extract of A. myriophylla as well as to investigate the anti-inflammatory activity and physicochemical properties of the developed herbal gel formulation containing standardized wood extract of A. myriophylla. Results of quantitative HPLC analysis demonstrated that the standardized wood extract of A. myriophylla contained 22.95 mg/g of 8-methoxy-7,3′,4′-trihydroxyflavone, a bioactive marker compound of A. myriophylla. The standardized wood extract of A. myriophylla (1% w/v) exhibited remarkable inhibition (54.4 – 80.3%) in the croton oil model of topical inflammation at all assessment times, comparable to standard indomethacin (55.3 – 63.6%). Real-time quantitative reverse transcription-polymerase chain reaction was performed to clarify the anti-inflammatory mechanism of standardized wood extract of A. myriophylla, and the result showed that this standardized extract decreased lipopolysaccharide-induced nitric oxide synthase mRNA levels in a dose-dependent manner. The developed herbal gel containing standardized wood extract of A. myriophylla (1% w/w) had good physicochemical characteristics and exhibited potent inhibition (51.4 – 77.8%) of inflammation in a rat ear edema model at all assessment times, comparable to indomethacin gel (33.3 – 40.5%). The notable anti-inflammatory activity of standardized wood extract of A. myriophylla and its developed herbal gel formulation indicates their potential application as natural anti-inflammatory agents.

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Identification and evaluation of anti-inflammatory properties of aqueous components extracted from sesame ( Sesamum indicum ) oil

Cited by 33 publications

References 61 publications

Anti-Inflammatory and Anticancer Properties of Bioactive Compounds from Sesamum indicum L.—A Review

Anti-Inflammatory and Anticancer Properties of Bioactive Compounds from Sesamum indicum L.—A Review

A systematic review on antioxidant and antiinflammatory activity of Sesame (Sesamum indicum L.) oil and further confirmation of antiinflammatory activity by chemical profiling and molecular docking

The Standardized Wood Extract of Albizia myriophylla: Its Potential as an Active Ingredient in an Anti-inflammatory Herbal Gel Formulation

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