Identification and measurement of veterinary drug residues in beehive products

Lozano, Ana; Hernando, M.D.; Uclés, Samanta; Hakme, Elena; Fernández‐Alba, Amadeo R.

doi:10.1016/j.foodchem.2018.08.055

Cited by 84 publications

(53 citation statements)

References 19 publications

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“…(2014) analysed 54 wax samples for 99 different residues, detecting 15 different active ingredients overall. Worldwide, numerous studies (Boi et al, 2016;Calatayud-Vernich et al, 2017;Chauzat and Faucon, 2007;Fulton et al, 2019;Harriet et al, 2017;Lozano et al, 2019;Serra-Bonvehí and Orantes-Bermejo, 2010;Shimshoni et al, 2019;Zawislak et al, 2019) acknowledge that beeswax is a major contamination sink for pesticide residues, thereby constituting hazardous health implications for bees and potentially for humans.…”

Section: Validation Of Analytical Methodsmentioning

confidence: 99%

“…Beeswax is a complex mixture consisting mainly of esters of higher fatty acids (Aichholz and Lorbeer, 1999;Tulloch, 1980). Due to its high composition in fatty acids, and as most acaricides are fat-soluble and nonvolatile (Wallner, 1999), beeswax is a relevant matrix to assess inhive chemical exposure history for lipophilic compounds (Lozano et al, 2019;Ravoet et al, 2015). Of all beehive products, it has the lowest replacement rate, can remain in the hive for many years and is recycled by the beekeepers into new wax foundations for comb building, thus leading to a greater accumulation of different pesticide residues used in beekeeping and agriculture (Chauzat and Faucon, 2007;Mullin et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

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Pesticide and veterinary drug residues in Belgian beeswax: Occurrence, toxicity, and risk to honey bees

Agrebi

Traynor

Wilmart

et al. 2020

Science of The Total Environment

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Pesticide and veterinary drug residues are one of the stress factors affecting bee health and mortality. To investigate the occurrence, the concentration and the toxicity risk to bees of pesticide residues in four different types of beeswax (brood comb wax, recycled comb wax, honey comb wax, and cappings wax), 182 samples were collected from apiaries located all over the Belgian territories, during spring 2016 and analysed by LC-MS/MS and GC-MS/MS for the presence of 294 chemical residues. The toxicity risk to bees expressed as the Hazard Quotient (HQ) was calculated for each wax sample, according to two scenarios with different tau-fluvalinate LD 50 values. Residues showing the highest prevalence were correlated to bee mortality in a multivariate logistic regression model and a risk-based model was used to predict colony bee mortality. Altogether, 54 different pesticide and veterinary drug residues were found in the four types of beeswax. The residues with a higher likelihood to be retained in beeswax are applied in-hive or with a high lipophilic nature. The multivariate logistic regression model showed a statistically significant influence of chlorfenvinphos on bee mortality. All our results indicated that cappings wax was substantially less contaminated. This national survey on beeswax contamination provides guidelines on the re-use of beeswax by beekeepers and shows the necessity to introduce maximum residue levels

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Section: Validation Of Analytical Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Pesticide and veterinary drug residues in Belgian beeswax: Occurrence, toxicity, and risk to honey bees

Agrebi

Traynor

Wilmart

et al. 2020

Science of The Total Environment

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“…As a lipophilic substance, coumaphos accumulates in various bee products, particularly in beeswax. As a result, residues from coumaphos-containing drugs have been found in the beeswax of European origin, as reported for Belgium (Ravoet et al 2015), France (Chauzat et al 2011), Germany (Wallner 1999), Switzerland (Bogdanov 2006), Italy (Boi et al 2016;Porrini et al 2016;Perugini et al 2018) and Spain (Orantes-Bermejo et al 2010;Calatayud-Vernich et al 2017;Lozano et al 2019), and also reviewed recently in Wilmart et al (2016). Substantial coumaphos levels have also been found in the beeswax of apiaries outside of Europe, such as for example in North America (Mullin et al 2010;Wu et al 2011;Ostiguy et al 2019;Fulton et al 2019) or Uruguay (Harriet et al 2017).…”

Section: Introductionmentioning

confidence: 76%

Distribution of coumaphos in beeswax after treatment of honeybee colonies with CheckMite® against the parasitical mite Varroa destructor

2019

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We studied the distribution of coumaphos in beeswax after a single application of CheckMite® to 15 bee colonies in the fall according to the manufacturer's instruction. Immediately after the treatment, residue levels were especially elevated in the wax that came into contact with the CheckMite® strips. During the following spring season, coumaphos levels ranged from 36 to 159 mg/kg in the wax of the brood frames next to the CheckMite® strips, and residue levels were about 10 times lower in the wax of frames that did not come into contact with the strips. Beeswax that was newly constructed 5 months after removing the treatment strips contained up to 7.3 mg/kg of coumaphos, and up to 0.5 and 2.3 mg/kg was detected in the honeycomb and capping wax, respectively. These results suggest that beeswax exposed to CheckMite® should not be recycled in order to prevent elevated concentrations of coumaphos in new foundations and hence to prevent honeybee larvae from being exposed to detrimental residue levels.beeswax / coumaphos / CheckMite® / honeybees / Apis mellifera / Varroa destructor

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“…There is evidence that residues of certain active substances used as pesticides may be transferred not only to honey, but also to other bee products (e.g. bee bread, pollen, beeswax) (Chauzat and Faucon, ; Wilmart et al., ; Calatayud‐Vernich et al., ; Lozano et al., ; Shimshoni et al., ).…”

Section: Residues In Plants/honeymentioning

confidence: 99%

Modification of the existing maximum residue level for boscalid in honey

Anastassiadou¹,

Brancato²,

Cabrera³

et al. 2019

EFS2

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In accordance with Article 6 of Regulation (EC) No 396/2005, the applicant BASF SE submitted a request to the competent national authority in Germany to modify the existing maximum residue level (MRL) for the active substance boscalid in honey and other apiculture products. The data submitted in support of the request were found to be sufficient to derive an MRL proposal for honey from field studies. This MRL proposal covers residues measured in honey samples analysed in the framework of EU National Monitoring Programmes. Adequate analytical methods for enforcement are available to control the residues of boscalid in honey at the validated limit of quantification (LOQ) of 0.01 mg/kg. Based on the risk assessment results, EFSA concluded that residues concentrations in honey at the level of the proposed MRL are unlikely to present a risk to consumer health.

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Identification and measurement of veterinary drug residues in beehive products

Cited by 84 publications

References 19 publications

Pesticide and veterinary drug residues in Belgian beeswax: Occurrence, toxicity, and risk to honey bees

Pesticide and veterinary drug residues in Belgian beeswax: Occurrence, toxicity, and risk to honey bees

Distribution of coumaphos in beeswax after treatment of honeybee colonies with CheckMite® against the parasitical mite Varroa destructor

Modification of the existing maximum residue level for boscalid in honey

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