Identification and pharmacological characterization of the anti-inflammatory principal of the leaves of dwarf elder (Sambucus ebulus L.)

Schwaiger, Stefan; Zeller, Iris; Pölzelbauer, Petra; Frotschnig, Sandra; Laufer, Günther; Meßner, Barbara; Pieri, Valerio; Stuppner, Hermann; Bernhard, David

doi:10.1016/j.jep.2010.10.049

Cited by 49 publications

(35 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…1 and 3) showed notable inhibitory activities on TNF-α and IL-1β production in LPS stimulated THP-1 cell lines. As visible, for example, from a comparison of the concentration used in this experiment with concentrations in previously published studies [27,28], the effect is promising enough to perform further experiments. Moreover, no sign of toxicity of extracts in our in vitro assay, and also in previous in vivo tests supports the idea of further testing.…”

Section: Resultsmentioning

confidence: 54%

Turkish Scorzonera Species Extracts Attenuate Cytokine Secretion via Inhibition of NF-κB Activation, Showing Anti-Inflammatory Effect in Vitro

et al. 2015

View full text Add to dashboard Cite

Scorzonera species are used in different folk medicines to combat many diseases, including the illnesses connected with inflammation. Previous experiments showed anti-inflammatory activity of Scorzonera extracts in vivo. S. latifolia, S. cana var. jacquiniana, S. tomentosa, S. mollis ssp. szowitsii, S. eriophora, S. incisa, S. cinerea, and S. parviflora extracts were, therefore, evaluated for their inhibitory activities of TNF-α and IL-1β production, and NF-κB nuclear translocation in THP-1 macrophages. The HPLC analysis was carried out to elucidate and to compare the composition of these extracts. Major compounds of the tested extracts have been isolated using different chromatographic techniques and further tested for their inhibitory activities on TNF-α and IL-1β production. Several extracts showed promising anti-inflammatory activity in these in vitro tests. Results of HPLC analysis revealed chlorogenic acid as a compound present in all tested extracts. Hyperoside, quercetin-3-O-β-D-glucoside and rutin were also present in varying amount in some Scorzonera species analyzed. Furthermore, eight phenolics which were identified as quercetin-3-O-β-D-glucoside (1), hyperoside (2), hydrangenol-8-O-glucoside (3), swertisin (4), 7-methylisoorientin (5), 4,5-O-dicaffeoyl-quinic acid (6), 3,5-di-O-caffeoyl-quinic acid (7), and chlorogenic acid (8) have been isolated as major phenolic compounds of the tested extracts and, together with eight terpenoids (9-16) previously obtained from different Scorzonera species, have been tested for the inhibition of TNF-α production, unfortunately with no activity comparable with standard.

show abstract

Section: Resultsmentioning

confidence: 54%

Turkish Scorzonera Species Extracts Attenuate Cytokine Secretion via Inhibition of NF-κB Activation, Showing Anti-Inflammatory Effect in Vitro

et al. 2015

View full text Add to dashboard Cite

show abstract

“…More recently, several studies assigned anti-neoplastic (in colon cancer cell line and hepatocellular carcinoma), antimicrobial (incl. antiviral) and anti-inflammatory properties to S. ebulus preparations (Tosun et al, 2004;Shokrzadeh et al, 2009;Schwaiger et al, 2011;Zahmanov et al, 2015). Sambucol 1 , among other Sambucus-based products, is now widely available on the market and is promoted as supplement to support the immune system (www.sambucol.co.uk; accessed in October 2014).…”

Section: Introductionmentioning

confidence: 99%

Metabolic differentiations of dwarf elder by NMR-based metabolomics

Zahmanov

Alipieva

Simova

et al. 2015

Phytochemistry Letters

View full text Add to dashboard Cite

“…Similarly, significant differences in S.nigra L. fruits acids content have been determined among elderberry species cultivers/wild (Table 1 Although studies of the active principles from species of Sambucus leaves are phenolic compounds and sambunigrin (Yesilada et al, 2014), but there are rich, particularly, in ursolic acid, use for the action of chronically inflammatory processes (Schwaiger et al, 2011).…”

Section: Organic Acids Composition Of Sambucus Nigra L Fruits Flowementioning

confidence: 99%

Chemical Profiles and Antioxidant Activity of Black Elder (Sambucus Nigra L.) - A Review

Petruţ¹,

Muste²,

Mureşan³

et al. 2017

BUASVMCN-FST

View full text Add to dashboard Cite

All plant parts of black elder (leaves, berries, inflorescences, roots, shoots, bark) have a long history of use in herbal remedy or lots of culinary uses, widespread in almost every continent of the world. Pro-health properties indicated a role of black elderberry products intake in the prevention of cancer and diabetes. This paper presents an overview of the evaluation of biochemical compounds (sugars, organic acids, total phenolics, antioxidative activity, flavonoids, flavor and volatile compounds), found in flowers, berries and leaves of Sambucus nigra L. The variability of concentration compounds are found by uniform maturity of each phenophase of black elder, hence the need varieties improve the quantity and quality of its yield. Black elder has food industry properties associated with the presence of increased nutritive and decreased caloric value at fruits best correlated with the content of sugars and organic acids of flower, organic acids as a important metabolic pathway of proteins, lipids, carbohydrates. Several studies have confirmed that Sambucus nigra L. is a valuable raw material with many nutrients and bioactive substances, being extraordinarily rich in antioxidants, and the leaves are remarked as easily available source of antioxidant preparations in different domains (food products, pharmaceutics, or cosmetics). A bush of Sambucus nigra L. in the garden is our true handy pharmacy, a food market like as functional ingredient, a spot of color with unmistakable smell.

show abstract

Identification and pharmacological characterization of the anti-inflammatory principal of the leaves of dwarf elder (Sambucus ebulus L.)

Cited by 49 publications

References 25 publications

Turkish Scorzonera Species Extracts Attenuate Cytokine Secretion via Inhibition of NF-κB Activation, Showing Anti-Inflammatory Effect in Vitro

Turkish Scorzonera Species Extracts Attenuate Cytokine Secretion via Inhibition of NF-κB Activation, Showing Anti-Inflammatory Effect in Vitro

Metabolic differentiations of dwarf elder by NMR-based metabolomics

Chemical Profiles and Antioxidant Activity of Black Elder (Sambucus Nigra L.) - A Review

Contact Info

Product

Resources

About