Identification and Structure Elucidation of Compounds from Herbal Medicines

Liang, Xinmiao; Jin, Yu; Feng, Jiatao; Ke, Yanxiong

doi:10.1002/9780470921340.ch4

Cited by 3 publications

(2 citation statements)

References 86 publications

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“…IR can take place in the near-, mid- or far-infrared regions, or use a Fourier Transform method to simultaneously beam many frequencies, repeated in bursts of different combinations over a short time and then calculate the absorbance at each wavelength. The near range, from 780–2,526 nm is the most commonly used in quality control due to having higher energy and penetration capacity and producing less heat ( Zeng et al, 2011 ) while the mid-infrared spectrum (2.5–25 µm) is superior for identifying structure and functional groups ( Liang et al, 2011 ).…”

Section: Resultsmentioning

confidence: 99%

Mitochondrial Function as a Potential Tool for Assessing Function, Quality and Adulteration in Medicinal Herbal Teas

Woodley¹,

Mould²,

Sahuri-Arisoylu³

et al. 2021

Front. Pharmacol.

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Quality control has been a significant issue in herbal medicine since herbs became widely used to heal. Modern technologies have improved the methods of evaluating the quality of medicinal herbs but the methods of adulterating them have also grown in sophistication. In this paper we undertook a comprehensive literature search to identify the key analytical techniques used in the quality control of herbal medicine, reviewing their uses and limitations. We also present a new tool, based on mitochondrial profiling, that can be used to measure medicinal herbal quality. Besides being fundamental to the energy metabolism required for most cellular activities, mitochondria play a direct role in cellular signalling, apoptosis, stress responses, inflammation, cancer, ageing, and neurological function, mirroring some of the most common reasons people take herbal medicines. A fingerprint of the specific mitochondrial effects of medicinal herbs can be documented in order to assess their potential efficacy, detect adulterations that modulate these effects and determine the relative potency of batches. Furthermore, through this method it will be possible to assess whole herbs or complex formulas thus avoiding the issues inherent in identifying active ingredients which may be complex or unknown. Thus, while current analytical methods focus on determining the chemical quality of herbal medicines, including adulteration and contamination, mitochondrial functional analysis offers a new way of determining the quality of plant derived products that is more closely linked to the biological activity of a product and its potential clinical effectiveness.

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Section: Resultsmentioning

confidence: 99%

Mitochondrial Function as a Potential Tool for Assessing Function, Quality and Adulteration in Medicinal Herbal Teas

Woodley¹,

Mould²,

Sahuri-Arisoylu³

et al. 2021

Front. Pharmacol.

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“…Compound ICW-V-a had a molecular ion at m/z 597 [M-H] À . It also showed an ion at m/z 477 [M-120-H] À that indicates a characteristic fragment ion of C-glycosyl flavonoids (Liang, Jin, Feng, & Ke, 2011). It has 1 H NMR and 13 C NMR spectral data as the followings: 1 H NMR (CD 3 OD, 500 MHz): phloretin (aglycone) moiety d7.03 (2H, d, J = 8.4 Hz, H2 and H6), 6.67 (2H, d, J = 8.4 Hz, H3 and H5), 3.34 (2H, m, Ha), 2.85 (2H, m, Hb); glucose moiety d4.93 (2H, d, J = 9.8 Hz, H1 00 , H1 00 0 ), 3.84 (2H, dd, J = 12.2 Hz and 2.1 Hz, H6a 00 , H6a 00 0 ), 3.80 (2H, dd, J = 12.2 Hz and 4.2 Hz, H6b 00 , H6b 000 ), 3.61 (2H, dd, J = 9 Hz and 9.5 Hz, H2 00 , H2 00 0 ), 3.54 (2H, dd, J = 9 Hz and 9 Hz, H3 00 , H3 00 0 ), 3.50 (2H, dd, J = 8.8 Hz and 8.8 Hz, H4 00 , H4 00 0 ), 3.42 (2H, m, H5 00 , H5 00 0 ).…”

Section: Analysis and Identification Of Phenolic Compounds In Extractmentioning

confidence: 99%

Tyrosinase inhibitory components of immature calamondin peel

Lou

2012

Food Chemistry

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Activité antioxydante de 53 plantes réputées antimalariques en République Démocratique du Congo

et al. 2021

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Objectif : Cette étude vise à identifier des groupes phytochimiques et à évaluer l’activité antioxydante de 53 plantes utilisées en médecine traditionnelle à Bagira dans le traitement de la malaria. Méthode : Le criblage phytochimique s’est effectué par des réactions classiques en solution, et l’activité antioxydante a utilisé la méthode in vitro au DPPH. Résultats : Le criblage chimique a permis d’identifier des métabolites secondaires à potentiel à la fois antimalarique et antioxydant comme des coumarines, des saponines, des stéroïdes, des tanins et des terpénoïdes dans plus de 70 % des plantes. Le criblage antioxydant a révélé pour la première fois l’activité antioxydante de 17 plantes parmi lesquelles Dalbergia katangensis, Dialium angolense et Solanecio cydoniifolius avec des CI50 inférieures ou égales à 1,6 μg/ml présentent les activités antioxydantes les plus élevées de la série. Conclusion : Cette étude montre que parmi les plantes réputées antimalariques à Bagira (RDC) plusieurs possèdent un pouvoir antioxydant et contiennent des groupes présumés à la fois antioxydants et antimalariques. Elle suggère que les études ultérieures se poursuivent en vue d’isoler les composés responsables de l’activité prouvée.

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Identification and Structure Elucidation of Compounds from Herbal Medicines

Cited by 3 publications

References 86 publications

Mitochondrial Function as a Potential Tool for Assessing Function, Quality and Adulteration in Medicinal Herbal Teas

Mitochondrial Function as a Potential Tool for Assessing Function, Quality and Adulteration in Medicinal Herbal Teas

Tyrosinase inhibitory components of immature calamondin peel

Activité antioxydante de 53 plantes réputées antimalariques en République Démocratique du Congo

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