Identification of 6-octadecynoic acid from a methanol extract of Marrubium vulgare L. as a peroxisome proliferator-activated receptor γ agonist

Ohtera, Anna; Miyamae, Yusaku; Nakai, N.; Kawachi, Atsushi; Kawada, Kunio; Han, Jianzhong; Isoda, Hiroko; Neffati, Mohamed; Akita, Toru; Maejima, Kazuhiro; Masuda, Seiji; Kambe, Taiho; Mori, Naoki; Irie, Kazuhiro; Nagao, Masaya

doi:10.1016/j.bbrc.2013.09.003

Cited by 25 publications

(18 citation statements)

References 25 publications

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“…There are few data available in literature about the measurement of the total alkaloid content in these plants; the same percentage (0.3) registered for Marrubium was found by Ohtera et al . [47] for the betonicine and stachydrine alkaloids.…”

Section: Resultsmentioning

confidence: 99%

Biochemical properties and in vitro biological activities of extracts from seven folk medicinal plants growing wild in southern Tunisia

Tlili

Najjaa

Arfa

et al. 2019

Preprint

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Recently, much attention has been paid to the extracts obtained from plant species in order to analyse their biological activities. Due to the climate diversity in Tunisia, the traditional pharmacopoeia consists of a wide arsenal of medicinal plant species since long used in folk medicine, in foods as spices, and in aromatherapy. Although many of these species are nearly facing extinction, only a small proportion of them have been scientifically studied. Therefore, this study explores the biochemical properties of seven spontaneous plants, which were harvested in the arid Tunisian desert: Marrubium vulgare L., Rhus tripartita (Ucria) D.C., Thymelaea hirsute (L.) Endl., Plantago ovata Forsk., Herniaria fontanesii J. Gay., Ziziphus lotus and Hyoscyamus albus. Extracts from these plants were found to contain different types of secondary metabolites (polyphenols, flavonoids, condensed tannins, crude saponins, carotenoids and alkaloids) that are involved in important biological activities. The biological activity of the extracts obtained from each Tunisian plant was assessed: first of all, leukaemia and colon cancer cell lines (K-562 and CaCo-2 respectively) were treated with different concentrations of extracts, and then the anti-proliferative activity was observed. The results showed, in particular, how the plant extract from Rhus tripartita significantly inhibits cell proliferation, especially on the K-562 tumour cell line. Subsequently, the anti-inflammatory activity was also assessed, and the results showed that Herniaria fontanesii and Marrubium vulgare possess the highest activity in the group of analysed plants. Finally, the greatest acetylcholinesterase inhibitory effect was exhibited by the extract obtained from Rhus tripartita.In conclusion, all the Tunisian plants we analysed were shown to contain a remarkable amount of different bio-active compounds, thus confirming their involvement in several biological activities. Rhus tripartita and Ziziphus lotus were shown to be particularly effective in anti-proliferative activity, while Herniaria fontanesii were shown to have the best anti-inflammatory activity.

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Section: Resultsmentioning

confidence: 99%

Biochemical properties and in vitro biological activities of extracts from seven folk medicinal plants growing wild in southern Tunisia

Tlili

Najjaa

Arfa

et al. 2019

Preprint

Self Cite

View full text Add to dashboard Cite

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“…Inne badanie pokazuje, że również izolowane z nadziemnych części M. vulgare pochodne fenyloetanoidowe (akteozyd, forsytozyd B, arenariozyd i ballotetrozyd) oraz kwas (+)-E-kawoilo-L-jabłkowy, odznaczają się zdolnością do hamowania utleniania lipoprotein niskiej gęstości (LDL), indukowanego jonami Cu 2+ lub 2,2'-azo-bis-(2-amidynopropanem) (AAPH) [35]. Ponadto wykazano, że metanolowe ekstrakty z ziela M. vulgare oraz wyizolowany z nich kwas 6-oktadecynowy cechują się zdolnością do wzmacniania sygnalizacji receptorów aktywowanych przez proliferatory peroksysomów (PPAR-γ) [36], biorących udział w regulacji procesów adipogenezy, metabolizmie węglowodanów i lipidów oraz syntezie adipokin [37]. W badaniu in vitro dowiedziono również, że wodno-etanolowy wyciąg z ziela szanty charakteryzuje się hamującym wpływem na α-glukozydazę -enzym z grupy hydrolaz obecny na powierzchni enterocytów, katalizujący ostatni etap procesu trawienia cukrów.…”

Section: Aktywność Hipoglikemiczna I Hipolipemizującaunclassified

Phytochemical profile and therapeutic potential of white horehound (Marrubium vulgare) – a review of the current state of knowledge

Magiera¹,

Marchelak²,

Owczarek³

et al. 2018

Farm Pol.

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“…Fibrogenesis is inhibited by PPARγ caused by hepatic stellate cells (HSCs), and ligands of these receptors were clinically used for the treatment of Type 2 diabetes. Methanol extract of M. vulgare was screened for activity to inhibit fibrosis in the HSC-T6 using oil red-O staining, which detects lipids accumulated in the cells [91]. Methanol extract found to have PPARγ agonist activity in a luciferase reporter assay.…”

Section: Antidiabetic and Antihyperlipidemic Activitymentioning

confidence: 99%

Marrubium vulgare L.: A review on phytochemical and pharmacological aspects

Lodhi¹,

Vadnere²,

Sharma³

et al. 2017

J Intercult Ethnopharmacol

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Marrubium vulgare L. (family: Lamiaceae), also known as the white horehound, is widely used as an herbal remedy for chronic coughs and colds. It is used in various disorders related to skin, liver, gastric, heart, and immune system. This review abridges phytochemical, pharmacological studies, and medicinal uses of M. vulgare and provides scientific proof for various ethnobotanical claims to identify gaps, which will give impulsion for novel research on M. vulgare based herbal medicines. This review summarizes selected scientific evidence on phytochemistry and pharmacological properties of M. vulgare over the past 48 years . Works related to M. vulgare was reviewed from various sources such as books, internet source, i.e., Google Search engine, PubMed, and Science Direct, and chemical abstract. The exhaustive literature was studied, and critical analysis was performed according to their phytochemical and pharmacological properties. Phytochemical investigations on different parts of M. vulgare have been reported the presence of flavonoids, steroids, terpenoids, tannins, saponins, and volatile oils (0.05%). The aerial parts contain marrubiin, together with ursolic acid and choline. Pharmacological activities such as antinociceptive, antispasmodic, antihypertensive, antidiabetic, gastroprotective, anti-inflammatory, antimicrobial, anticancer, antioxidant, and antihepatotoxic activity have been reported. M. vulgare has therapeutic potential in the treatment of inflammatory conditions, liver disorders, pain, cardiovascular, gastric, and diabetic conditions. Aerial parts of M. vulgare is a good source of labdane type diterpene especially marrubiin which is present in high concentrations. However, further scientific studies are needed to explore clinical efficacy, toxicity and to explore the therapeutic effect of major secondary metabolites such as diterpenes, phenylpropanoid, and phenylethanoid glycosides of M. vulgare.

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Identification of 6-octadecynoic acid from a methanol extract of Marrubium vulgare L. as a peroxisome proliferator-activated receptor γ agonist

Cited by 25 publications

References 25 publications

Biochemical properties and in vitro biological activities of extracts from seven folk medicinal plants growing wild in southern Tunisia

Biochemical properties and in vitro biological activities of extracts from seven folk medicinal plants growing wild in southern Tunisia

Phytochemical profile and therapeutic potential of white horehound (Marrubium vulgare) – a review of the current state of knowledge

Marrubium vulgare L.: A review on phytochemical and pharmacological aspects

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