Identification of a cycle-modulated 200-kDa endometrial antigen by a monoclonal antibody LDS60

Habiba, Marwan; James, R. F. L.; Bell, Steven; Al‐Azzawi, Farook

doi:10.1016/s0022-1759(99)00070-8

Cited by 2 publications

(2 citation statements)

References 14 publications

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“…This term was chosen to align with the terms used for exosomes/ microvesicles identified in the male reproductive tract; namely, epididymosomes and prostasomes which are both involved in post-testicular sperm maturation (12,13). It should be noted that although in their 1999 paper Habiba et al detected in women a large protein that was secreted from the glandular and luminal epithelia of the endometrium and could later be detected in the lumen, the protein was never seen in EVs (it was seen in intracellular vesicles) (20). In a more recent study in women, the isolation and characterization of exosomes and microvesicles from the uterine luminal fluids was demonstrated (21).…”

Section: Classification and Biogenesis Of Uterosomesmentioning

confidence: 73%

Uterosomes Exosomal cargo during the estrus cycle and interaction with sperm

Martin‐DeLeon

2016

Front Biosci

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The term "uterosomes" was first used to classify extracellular membrane vesicles released into the uterine luminal fluid. These extracellular vesicles (EVs), varying in sizes, fit the classification of exosomes and microvesicles on the basis of size, the presence of the CD9 biochemical marker, and lateral orientation of the membrane. Uterosomes appear to be formed by the apocrine pathway, similar to other reproductive EVs. In the murine system, the protein cargo carried by uterosomes includes glycosyl phosphatidylinositol (GPI)-linked and transmembrane proteins and these are hormonally regulated, appearing at high levels during proestrus/estrus and only marginally present at diestrus /metestrus. Uterosomes have been shown to deliver proteins in their cargo to sperm, with a functional impact, and are thought to participate in promoting sperm capacitation. Further studies are warranted, particularly those aimed at identifying the contents of their cargo during the estrus and menstrual cycle and the role they play n sperm maturation.

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Section: Classification and Biogenesis Of Uterosomesmentioning

confidence: 73%

Uterosomes Exosomal cargo during the estrus cycle and interaction with sperm

Martin‐DeLeon

2016

Front Biosci

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“…Recent studies have confirmed that uterine epithelial cells also shed exosomes and microvesicles. The first report of this was by Habiba et al (77). These authors reported the presence of a large glycoprotein, of approximately 200,000 MW in the endometrium of women.…”

Section: Endometrial Extracellular Vesiclesmentioning

confidence: 95%

Exosomes mediate embryo and maternal interactions at implantation and during pregnancy

Nowak¹

2016

Front Biosci

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Shedding of exosomes and microvesicles is now a well-recognized, important method of cell-cell communication in a number of different cell types. However, their importance in the female reproductive tract and in mediating embryo-maternal interactions during pregnancy has only recently been recognized. Here we review the current literature as to release of extracellular vesicles by uterine cells, the embryo,, and placental trophoblast cells; how release is regulated; and the different types of signaling molecules and genetic information contained within such vesicles. We also discuss the role of these exosomes and microvesicles in regulating critical processes during implantation and pregnancy such as angiogenesis, matrix remodeling, alterations in immune function and pathological effects in gestational diseases. A better understanding of the role of exosomes and microvesicles in reproduction may lead to the development of new therapeutic approaches for treatment of infertility and pregnancy complications.

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Identification of a cycle-modulated 200-kDa endometrial antigen by a monoclonal antibody LDS60

Cited by 2 publications

References 14 publications

Uterosomes Exosomal cargo during the estrus cycle and interaction with sperm

Uterosomes Exosomal cargo during the estrus cycle and interaction with sperm

Exosomes mediate embryo and maternal interactions at implantation and during pregnancy

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