Identification of a new bovine viral diarrhea virus subtype in the Republic of Korea

Han, Du-Gyeong; Ryu, Ji-Hyung; Park, Jinho; Choi, Kwang Shik

doi:10.1186/s12917-018-1555-4

Cited by 16 publications

(13 citation statements)

References 26 publications

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“…Cattle are the natural host for BVDV (Walz et al ., 2010) and infections with the virus are endemic in cattle populations in many different parts of the world (Chernick and van der Meer, 2017; Velasova et al ., 2017; Yesilbag et al ., 2017; Aragaw et al ., 2018; Han et al ., 2018; Scharnbock et al ., 2018). The prevalence of BVDV infection based on serological surveys in different geographic regions range from 40 to 90% in individual cattle and 28–66% in cattle herds, while 0.5–2.5% of cattle were persistently infected (PI) with the virus (Walz et al ., 2010; Velasova et al ., 2017; Scharnbock et al ., 2018).…”

Section: Introductionmentioning

confidence: 99%

Mechanisms linking bovine viral diarrhea virus (BVDV) infection with infertility in cattle

Oguejiofor

Thomas

Cheng

et al. 2019

Anim. Health. Res. Rev.

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Bovine viral diarrhea virus (BVDV) is an important infectious disease agent that causes significant reproductive and economic losses in the cattle industry worldwide. Although BVDV infection is known to cause poor fertility in cattle, a greater part of the underlying mechanisms particularly associated with early reproductive losses are not clearly understood. Previous studies reported viral compromise of reproductive function in infected bulls. In females, BVDV infection is thought to be capable of killing the oocyte, embryo or fetus directly, or to induce lesions that result in fetal abortion or malformation. BVDV infections may also induce immune dysfunction, and predispose cattle to other diseases that cause poor health and fertility. Other reports also suggested BVDV-induced disruption of the reproductive endocrine system, and a disruption of leukocyte and cytokine functions in the reproductive organs. More recent studies have provided evidence of viral-induced suppression of endometrial innate immunity that may predispose to uterine disease. Furthermore, there is new evidence that BVDV may potentially disrupt the maternal recognition of pregnancy or the immune protection of the conceptus. This review brings together the previous reports with the more recent findings, and attempts to explain some of the mechanisms linking this important virus to infertility in cattle.

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Section: Introductionmentioning

confidence: 99%

Mechanisms linking bovine viral diarrhea virus (BVDV) infection with infertility in cattle

Oguejiofor

Thomas

Cheng

et al. 2019

Anim. Health. Res. Rev.

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“…Few studies have reported BVDV infection in goats in the ROK [15, 16], and little is known about BVDV circulation and transmission in goat farms. Recently, we found that BVDV-1b is the predominant subtype circulating among Korean indigenous cattle [17]. Therefore, here, we aimed to investigate whether BVDV-1b infection can be established in Korean native goats via intranasal (IN) inoculation, evaluate the circulation of BVDV between cattle and Korean native goats, and characterize the outcome of BVDV infection in Korean native goats.…”

Section: Introductionmentioning

confidence: 99%

Experimental infection of Korean native goats (Capra aegagrus hircus) with bovine viral diarrhea virus 1b

2019

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Background Bovine viral diarrhea virus (BVDV) infects various ungulates and causes reproductive failure in infected goats. BVDV has been detected among goats in the Republic of Korea, but the route of transmission remains unclear. Here, we aimed to investigate whether BVDV-1b circulating among Korean cattle can be transmitted to Korean native goats ( Capra aegagrus hircus ) and characterize the outcomes of BVDV infection in these goats. Results Four goats were inoculated intranasally with the Korean noncytopathic (ncp) BVDV-1b strain. Two goats exhibited clinical signs of illness, including coughing and nasal discharge. Nasal swabs and blood were collected to screen for viral RNA and BVDV antibodies. Using the 5′-untranslated region (UTR), viral RNA was detected in the nasal swabs of two goats (Goat 1 and 3) on 12 day post-inoculation (dpi) and in the blood sample of one goat (Goat 1) on 7 and 19 dpi. Using the N-terminal protease (N pro ) region, viral RNA was detected in the blood sample of Goat 1 on 7 and 12 dpi. Antibodies to BVDV were detected in Goats 1 and 3 on 16–21 dpi using enzyme-linked immunosorbent assay. Sequence analysis of the virus from nasal swabs and blood samples, which was detected via RT-PCR, using the 5′-UTR and N pro regions led to the identification of the strain as ncp BVDV-1b and revealed changes in the nucleotide sequence of these goats. Conclusions Our results indicate that changes in the nucleotide sequence are associated with the establishment of BVDV infection in Korean native goats; these changes may be owing to a process required for the establishment of infection in a new host reservoir. Broadly, these findings highlight the importance of BVDV surveillance in ungulates other than cattle. Electronic supplementary material The online version of this article (10.1186/s12917-019-1955-0) contains supplementary material, which is available to authorized users.

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“…In Ireland, BVDV infection was detected in 98.7% of nonvaccinated herds (Cowley et al 2012). In addition, BVDV-1b and BVDV-1e were the most prevalent subtypes circulating in Italy, whereas the BVDV-1a and BVDV-2a subtypes were predominant and widespread in Korea (Bazzucchi et al 2017;Han et al 2018). The prevalence of persistently infected cattle from selected, nonrandom sample in six large South African feedlots was 2.9% (Meiring et al 2011), while prevalence of PI calves in Japan in a dairy herd was estimated about 7.0%, which was very high ratio compared to that in previous reports (Helal et al 2012).…”

Section: Introductionmentioning

confidence: 99%

Prevalence of bovine viral diarrhea virus in dairy cattle herds in eastern China

Hou

Zhao

Wang

et al. 2018

Trop Anim Health Prod

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Bovine viral diarrhea virus (BVDV) is a worldwide spreading pestivirus affecting cattle and other ruminants; however, there have been few reports on epidemiologic investigation of BVDV in eastern China. In this study, bulk tank milk from 36 herds of dairy cattle in eastern China was submitted to serological investigations, 77.8% of herds was BVDV antibody positive. Individual animal status in two herds was further investigated collecting blood samples, the positive ratio was 49.74% and 24.64%, and the average positive ratio of calves, heifers, and lactating cows was 15.94%, 40.16%, and 41.7%, respectively. Moreover, clinical survey was carried out among 8170 dairy cattle from 36 herds, for diarrhea syndrome, respiratory problems and reproductive failure, and pathogens of all clinical cattle were further investigated. The results showed that BVDV was one of the main pathogen, which infected animals combining with various other viruses. Then, nine BVDV strains were isolated; phylogenetic analysis showed that BVDV subtypes currently circulating in eastern China were BVDV 1a and BVDV 1c. In addition, out of 377 cows tested, the 1.86% detected positive to the BVDV antigen. This study provided the foundation of further study on vaccination and control strategies of BVDV in eastern China.

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Identification of a new bovine viral diarrhea virus subtype in the Republic of Korea

Cited by 16 publications

References 26 publications

Mechanisms linking bovine viral diarrhea virus (BVDV) infection with infertility in cattle

Mechanisms linking bovine viral diarrhea virus (BVDV) infection with infertility in cattle

Experimental infection of Korean native goats (Capra aegagrus hircus) with bovine viral diarrhea virus 1b

Prevalence of bovine viral diarrhea virus in dairy cattle herds in eastern China

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