Identification of a new impurity in lisinopril

Characterization of degradation products resulted from acidic hydrolysis of lisinopril under drastic conditions

“…A wide variety of separation and detection techniques have been applied to the analysis of lisinopril, such as gas chromatography coupled with mass spectrometry (GC/MS) [3][4] , high performance liquid chromatography (HPLC) [5][6] , and high performance liquid chromatography coupled with mass spectrometry (HPLC/MS) [7][8] . The degradation profile of a drug substance is critical to its safety assessment and formulation process in addition to dosage form administration.…”

Pharmaceutical impurities and degradation products: Uses and applications of NMR techniques

“…Some examples found in recent literature point out to special precautions required during complex syntheses. The structural analysis (MS, IR, and 200 MHz 1 H and 13 C NMR) of an impurity isolated from lisinopril revealed it to be a result from incomplete protection of the starting material [136]. An impurity was isolated from benazepril and subjected to spectroscopic analysis using LC-MS/MS, MS, NMR ( 1 H and 13 C) and FT-IR.…”

Application of Differential Scanning Calorimetry and Fourier Transform Infrared Spectroscopy to the Study of Metoprolol-Excipient and Lisinopril-Excipient Compatibility

“…Lisinopril members angiotensin converting enzyme (ACE) inhibitors and belongs to a group of cardiovascular pharmaceuticals group. They are generally used for the treatment of high blood pressure, angina, arrhythmias, hyperthyroidism, myocardial infarction [14][15][16][17][18]. Excipients can be classified as the basis of their origin, mechanisms and they use in dosage form-functions [19].…”