Abstract-This paper provides the possible application of the fuzzy approaches in fault detection and isolation area for a class of complex industrial processes with uncertain interval parameters. The main idea of fuzzy fault detection and isolation is to build a model of a diagnosis procedures, using rules-based Fuzzy Expert System, capable to minimize false alarms enhance detectability and isolability and minimize detection time by hardware implementation to improve reliability, safety and global efficiency. This paper illustrates an alternative implementation to the compression systems supervision task using the basic principles of model-based fault detection and isolation associated with the self-tuning of surge measurements with subsequent appropriate corrective actions. Using a combination of fuzzy modeling approach makes it possible to devise a fault-isolation scheme based on the given incidence matrix. Simulation results of a fault detection and isolation for a compression system are provided, which illustrate the relevance of the proposed FDI method.