The scarcity of surface water resources in the dry season in the Kilinochchi district increases the demand for freshwater. Therefore, the main objective of this study is to delineate potential groundwater zones in Kilinochchi, Sri Lanka, using integrated remote sensing (RS), geographic information systems (GIS) and the analytical hierarchy process (AHP). Groundwater potential zones are demarcated for the Kilinochchi district by overlaying thematic layers: geology, geomorphology, land use/land cover, soil types, drainage density, slope, lineament, and rainfall. The thematic layers were integrated into a geographic information system, and a weighted overlay analysis was carried out to delineate groundwater zones. Thus the resultant map is categorized into five different potential zones: very low (59.12 km2), low (207.78 km2), moderate (309.89 km2), high (507.74 km2), and very high (111.26 km2). The groundwater potential map was validated with the existing seventy-nine wells, which indicated a good prediction accuracy of 81.8%. This suggests that the results obtained by integrating RS-GIS and AHP are well-matched with the existing well water depth. The AHP approach based on RS-GIS was a handy and efficient technique for assessing potential groundwater zones. This research will help policymakers better manage the Kilinochchi district’s groundwater resources and give scope for further research into groundwater exploration in the area.