Identification of Mammaglobin B, a Novel Member of the Uteroglobin Gene Family

Becker, Robert M.; Darrow, Christopher; Zimonjic, Drazen B.; Popescu, Nicholas C.; Watson, Mark A.; Fleming, Timothy P.

doi:10.1006/geno.1998.5539

Cited by 67 publications

(64 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A high percentage of proliferating cells is often correlated with a poor prognosis Her2/neu status is evaluated by immunohistochemistry and confirmed by FISH [8] Control groups (Table 2) For qPCR analysis, 21 normal ovarian cortical samples from 21 patients with benign gynecological disease (23-36 years of age) were used as negative controls. As positive controls, breast tumors (n =4) [4] and ovarian cancers (n =3) [40] were chosen.…”

Section: Patientsmentioning

confidence: 99%

“…Breast cancers are composed of a heterogeneous collection of cells showing differing degrees of tumor marker expression [5]. Mammaglobin (MGB1) and mammaglobin B (MGB2) are 2 related genes of the uteroglobin gene family that are overexpressed in breast tissue and metastatic lymph nodes from patients with breast cancer [4,47,48]. After careful analysis of the literature on micrometastasis detection in sentinel lymph nodes, we selected the MGB2 gene as one of the most specific PCR markers to detect potential malignant breast cell invasion in our cryopreserved ovarian tissue [1,4,20,30,34].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Is transplantation of cryopreserved ovarian tissue from patients with advanced-stage breast cancer safe? A pilot study

Luyckx

Durant

Camboni

et al. 2013

J Assist Reprod Genet

View full text Add to dashboard Cite

Section: Patientsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Is transplantation of cryopreserved ovarian tissue from patients with advanced-stage breast cancer safe? A pilot study

Luyckx

Durant

Camboni

et al. 2013

J Assist Reprod Genet

View full text Add to dashboard Cite

“…The peptides FHG22-(24 -45) and FHG22- (55)(56)(57)(58)(59)(60)(61)(62)(63)(64)(65)(66) contain an extra Cys with respect to the deduced sequence in the carboxyl and amino terminus, respectively, for coupling purposes. The three peptides were coupled to keyhole limpet hemocyanin (Pierce) via Cys using the linking agent Sulfosuccinimidyl 4-(N-maleimido-methyl)cyclohexane-1-carboxylate.…”

Section: Animals-male and Female Syrian Hamsters (Mesocricetus Auratus)mentioning

confidence: 99%

Characterization and Cloning of Two Isoforms of Heteroglobin, a Novel Heterodimeric Glycoprotein of the Secretoglobin-Uteroglobin Family Showing Tissue-specific and Sex Differential Expression

Álvarez¹,

Viñas²,

Alonso³

et al. 2002

Journal of Biological Chemistry

View full text Add to dashboard Cite

“…Mammaglobin (MGB1) and mammaglobin-2 are highly homologous 4 and are expressed specifically in breast tissue. [1][2][3] Some studies have shown that MGB1 and mammaglobin-2 are useful mRNA markers for detecting lymph node metastasis of breast cancer.…”

mentioning

confidence: 99%

Breast-specific expression of MGB1/mammaglobin: an examination of 480 tumors from various organs and clinicopathological analysis of MGB1-positive breast cancers

Sasaki

Tsunoda

Hatanaka³

et al. 2007

Modern Pathology

124

View full text Add to dashboard Cite

Previously, we used the reverse transcription-polymerase chain reaction (RT-PCR) to show that mammaglobin (MGB1) can serve as a differential marker of breast cancer metastasis from primary lung cancer. However, mRNA-based methods are not appropriate for use in clinical practices. In this study, we examined MGB1 protein expression in 480 tumors from various organs using immunohistochemical detection and a tissue microarray technique. Breast cancers expressing MGB1 were also analyzed clinicopathologically to determine whether these cancers constitute a characteristic subset. Immunohistochemically, MGB1 was expressed specifically in breast cancers. Of the other cancers examined, including 29 of the head and neck, eight of the thyroid, 106 of the lung, 35 of the gastrointestinal tract, three of the pancreas, 14 of the uterine cervix and 13 of the ovary, none were positive for MGB1 except a proportion of salivary gland tumors (6/11, 55%) and endometrial cancers (3/23, 13%). Among the 238 breast cancers, MGB1 was expressed in 114 (48%), most of which were classified histologically as invasive duct or lobular carcinomas. Clinicopathologically, MGB1 expression was associated with positive expression of estrogen receptors and negative expression of CK5, but not with pathological stage, HER2 gene amplification or p53 immunoreactivity. Kaplan-Meier analysis revealed prolonged disease-free survival in patients with MGB1-positive breast cancers (log rank test, P ¼ 0.016), but the Cox proportional hazard model failed to confirm that MGB1 was an independent prognostic factor (hazard ratio 1.77, P ¼ 0.1755). In terms of practical diagnosis, MGB1 immunohistochemistry can serve as a differential marker of breast cancer metastasis from primary lung cancer for two reasons. Firstly, HER2-positive breast cancer frequently lacks estrogen receptor expression, but MGB1 is expressed in about half of this subtype. Secondly, as primary lung adenocarcinomas may express estrogen receptors, MGB1 expression provides further discrimination of the origin of breast cancers.

show abstract

Identification of Mammaglobin B, a Novel Member of the Uteroglobin Gene Family

Cited by 67 publications

References 18 publications

Is transplantation of cryopreserved ovarian tissue from patients with advanced-stage breast cancer safe? A pilot study

Is transplantation of cryopreserved ovarian tissue from patients with advanced-stage breast cancer safe? A pilot study

Characterization and Cloning of Two Isoforms of Heteroglobin, a Novel Heterodimeric Glycoprotein of the Secretoglobin-Uteroglobin Family Showing Tissue-specific and Sex Differential Expression

Breast-specific expression of MGB1/mammaglobin: an examination of 480 tumors from various organs and clinicopathological analysis of MGB1-positive breast cancers

Contact Info

Product

Resources

About