Identification of N-Acetyldopamine Dimers from the Dung Beetle Catharsius molossus and Their COX-1 and COX-2 Inhibitory Activities

Lü, Juan; Sun, Qin; Tu, Zhengchao; Lv, Qing; Pi-xian, Shui; Cheng, Yong‐Xian

doi:10.3390/molecules200915589

Cited by 23 publications

(20 citation statements)

References 7 publications

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“…Chemical screening of some herbs and insects have confirmed the presence of various types of bioactive substances . Catharsius molossus , commonly referred to as ‘dung beetles,’ have been used in traditional medicine for centuries in China . These insects can be propagated at large scale, and therefore, the EECM is readily available and economical.…”

Section: Discussionmentioning

confidence: 99%

“…We show that the EECM feeding method significantly increases triterpene acid production. The C. molossus insect is one of the most widespread species on the Earth . Attacks on basidiomycetes fungi (mushroom) from insects is widespread in natural habitats, invariably leading to interactions between the insects and mushrooms .…”

Section: Discussionmentioning

confidence: 99%

“…27,28 Catharsius molossus, commonly referred to as 'dung beetles,' have been used in traditional medicine for centuries in China. 29 These insects can be propagated at large scale, and therefore, the EECM is readily available and economical. Our previous work showed that the addition of the EECM at the start of shake flask culture of G. lucidum markedly enhanced the total triterpene production.…”

Section: Discussionmentioning

confidence: 99%

“…The C. molossus insect is one of the most widespread species on the Earth. 29 Attacks on basidiomycetes fungi (mushroom) from insects is widespread in natural habitats, invariably leading to interactions between the insects and mushrooms. 30 The C. molossus EECM (mainly fatty acid derivatives) has been hypothesized to be used as a signaling molecule that mediates interactions between the insect and G. lucidum.…”

Section: Discussionmentioning

confidence: 99%

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Enhanced triterpene acid production by Ganoderma lucidum using a feeding stimulus integrated with a two‐stage pH‐control strategy

Wang

Yang

Liu

2016

J of Chemical Tech & Biotech

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BACKGROUND Triterpenes (especially triterpene acids) are some of the major physiologically active components of Ganoderma lucidum. However, submerged fermentation techniques for triterpenes have not been optimized for commercial use, and the total triterpene yield is still very low. The aim of this work was to develop a two‐stage pH‐control strategy integrated with the use of an ether extract from the medicinal insect, Catharsius molossus (EECM), as a stimulus for enhanced G. lucidum triterpene acid production. RESULTS Triterpene acid production of 302.76 mg L−1 was obtained in G. lucidum cultured with the EECM; this production was higher by 60% than that of the control cultures not fed the EECM. Based on the EECM feeding method, a new two‐stage pH‐control strategy was integrated, resulting in triterpene acid yields of 361.47 mg L−1. Subsequent studies optimized the interaction between EECM feeding and two‐stage pH‐control strategies, which resulted in an optimal EECM concentration of 185.89 mg L−1 and optimal pH values of 5.07 in the first 72 h incubation and 4.37 after 72 h, with a maximum triterpene acid concentration of 449.37 mg L−1. This represented a 137% increase compared with that of the control cultures. Furthermore, when a 150 L fermenter was used under these conditions, a triterpene acid concentration of 431.83 mg L−1 was achieved. CONCLUSIONS The enhanced production of triterpene acid in submerged cultures of G. lucidum was achieved using an EECM feeding stimulus integrated with a two‐stage pH‐control strategy at large scale. © 2016 Society of Chemical Industry

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Enhanced triterpene acid production by Ganoderma lucidum using a feeding stimulus integrated with a two‐stage pH‐control strategy

Wang

Yang

Liu

2016

J of Chemical Tech & Biotech

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“…Meskipun tempat yang tertutup naungan disukai, kumbang ini juga mampu beradaptasi padanaungan terbuka. Menurut Ma et al (2015); Lu et al (2015) Catharsius molossus adalah spesies yang berasal dari genus Catharsius, memiliki peran penting di ekosistem dan berpotensi menjadi bahan obat (Gambar 3).…”

Section: Cattarsius Mollosusunclassified

Kelimpahan Dan Kelimpahan Relatif Dung Beetle Di Hutan Pendidikan Konservasi Terpadu Universitas Lampung Pada Blok Lindung Tahura Wan Abdul Rachman

Rahmawati

Dewi

Harianto

et al. 2019

GJFR

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Kelimpahan dan kelimpahan relatif dung beetle berperan penting sebagai bioindikator kerusakan hutan dan habitat. Tujuan penelitian untuk menganalisis kelimpahan spesies dan kelimpahan relatif spesies dung beetle di Hutan Pendidikan Konservasi Terpadu Universitas Lampung Blok Lindung, Tahura Wan Abdul Rachman pada Desember 2018-Februari 2019. Metode yang digunakan adalah metode trap, kemudian data yang terkumpul dianalisis dengan indeks kelimpahan dan indeks kelimpahan relatif. Hasil penelitian menunjukkan bahwa kelimpahan spesies dung beetle termasuk sedang dengan nilai 3,53 yang menggambarkan keadaan Hutan Pendidikan Tahura Wan Abdul Rachman masih tergolong baik. Ada empat jenis dung beetle yang ditemukan yaitu Catharsius molossus, Onthophagus sp, Aphodius marginellus dan Oryctes rinocheros. Kelimpahan relatif seluruhnya termasuk tinggi dengan nilai di atas 20% hal ini karena jumlah setiap jenis dung beetle yang ditemukan hampir sama. Pengelola sebaiknya menjaga kelestarian hutan dengan mencegah terjadinya penebangan liar.

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Recent Advances in the Insect Natural Product Chemistry: Structural Diversity and Their Applications

Rather

Ansari

2020

Natural Materials and Products From Insects: Chemistry and Applications

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Identification of N-Acetyldopamine Dimers from the Dung Beetle Catharsius molossus and Their COX-1 and COX-2 Inhibitory Activities

Cited by 23 publications

References 7 publications

Enhanced triterpene acid production by Ganoderma lucidum using a feeding stimulus integrated with a two‐stage pH‐control strategy

Enhanced triterpene acid production by Ganoderma lucidum using a feeding stimulus integrated with a two‐stage pH‐control strategy

Kelimpahan Dan Kelimpahan Relatif Dung Beetle Di Hutan Pendidikan Konservasi Terpadu Universitas Lampung Pada Blok Lindung Tahura Wan Abdul Rachman

Recent Advances in the Insect Natural Product Chemistry: Structural Diversity and Their Applications

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