Identification of Novel “Inks” for 3D Printing Using High-Throughput Screening: Bioresorbable Photocurable Polymers for Controlled Drug Delivery

Abstract

A robust methodology is presented to identify novel biomaterials suitable for three-dimensional (3D) printing. Currently, the application of additive manufacturing is limited by the availability of functional inks, especially in the area of biomaterials; this is the first time when this method is used to tackle this problem, allowing hundreds of formulations to be readily assessed. Several functional properties, including the release of an antidepressive drug (paroxetine), cytotoxicity, and printability, are screened for 253 new ink formulations in a high-throughput format as well as mechanical properties. The selected candidates with the desirable properties are successfully scaled up using 3D printing into a range of object architectures. A full drug release study and degradability and tensile modulus experiments are presented on a simple architecture to validating the suitability of this methodology to identify printable inks for 3D printing devices with bespoke properties.

Hydrogel screening approaches for bone and cartilage tissue regeneration

“…For example, Louzao et al . developed a technique to screen hundreds of potential biomaterial bioinks for 3D printing . Although the main application of this platform was drug release and cytocompatibility, this method can be easily adapted to identify osteo‐ and chondroinductive bioinks.…”

Customisable Tablet Printing: The Development of Multimaterial Hot Melt Inkjet 3D Printing to Produce Complex and Personalised Dosage Forms

“…In recent decades, 3D printing has been recognised by many to be an answer to this call and the future of polypharmacy [12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29]. The possibility to mass-produce personalised components without substantially increasing production time or costs makes 3D printing an attractive proposition [12][13][14].…”

Conjugated Bifunctional Carbazole‐Based Oxime Esters: Efficient and Versatile Photoinitiators for 3D Printing under One‐ and Two‐Photon Excitation

“…Three‐dimensional (3D) printing, an additive manufacturing technology supported by computer‐aided design, has attracted wide attention from both academic and industrial research . The rapid development of printing instruments as well as the corresponding materials opens the door for 3D printing technology to find applications in various high‐tech and emerging fields such as flexible electronic devices, dentistry, microfluidics and drug delivery . Among various 3D printing approaches, stereolithography methods based on photopolymerization has become extremely attractive because such technology enables fabrication of well‐defined structures containing highly accurate and complex parts with micrometer resolution .…”

“…[1] The rapid development of printing instruments as well as the corresponding materials opens the door for 3D printing technology to find applications in various high-tech and emerging fields such as flexible electronic devices, [2] dentistry, [3] microfluidics [4] and drug delivery. [5,6] Among various 3D printing approaches, stereolithography methods based on photopolymerization has become extremely attractive because such technology enables fabrication of well-defined structures containing highly accurate and complex parts with micrometer resolution. [7] When employing a femtosecond pulsed laser as an irradiation source, the size of the objects can be as low as nanometer scale because the polymerization based on twophoton absorption (2PA) locally occurs within the narrow focal region of the pulsed laser beams.…”