2008
DOI: 10.1111/j.1601-183x.2008.00415.x
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Identification of quantitative trait loci for locomotor activation and anxiety using closely related inbred strains

Abstract: We carried out a QTL mapping experiment in two phenotypically similar inbred mouse strains, C57BL/6J and C58/J, using the open field assay, a well-established model of anxiety-related behavior in rodents. This intercross was initially carried out as a control cross for an ENU-mutagenesis mapping study. Surprisingly, although open field behavior is similar in the two strains, we identified significant QTL in their F2 progeny. Marker regression identified a locus on chromosome 8 having associations with multiple… Show more

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Cited by 24 publications
(26 citation statements)
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“…Rearing behavior is thought to be a novelty-evoked exploratory behavior that may contain components of both activity and anxiety (Bailey et al, 2008;Eisener-Dorman et al, 2010;Henderson et al, 2004). However, in our study, rearing behavior appeared to be independent of locomotor activity as evidenced by the observation of significantly decreased rearing along with no change in locomotor activity in multiple tests.…”
Section: Discussioncontrasting
confidence: 74%
“…Rearing behavior is thought to be a novelty-evoked exploratory behavior that may contain components of both activity and anxiety (Bailey et al, 2008;Eisener-Dorman et al, 2010;Henderson et al, 2004). However, in our study, rearing behavior appeared to be independent of locomotor activity as evidenced by the observation of significantly decreased rearing along with no change in locomotor activity in multiple tests.…”
Section: Discussioncontrasting
confidence: 74%
“…For behavioral quantitative traits, however, epistatic networks identified by genome scans remain rare (for exceptions, see Wright et al 2006;Bailey et al 2008). In this cross, a network of Tame-1 and Tame-2 and three additional loci that were identified only as part of these epistatic pairs influence tameness ( Figure 5A).…”
Section: Discussionmentioning
confidence: 99%
“…This finding highlights the importance of mapping quantitative traits that are not predicted by the parental strains, because complex phenotypes can be governed by many, often conflicting, genetic contributions that can be uncovered in segregating crosses. This has been observed in other phenotypes as well, for example in a study of anxiety (Bailey et al 2008) where strong effects were identified in segregating crosses of two strains with very little phenotypic difference, and in plasmocytomagenesis (Mock et al 1993; Zhang et al 2009) where a tumor resistance allele was found in a highly susceptible strain. Further studies are necessary to determine whether overall resistance in the 129 strain is due to the combinatorial effects of many different loci that did not reach the threshold of statistical significance in this study.…”
Section: Discussionmentioning
confidence: 61%