Identification of the tannins in traditional Chinese medicine Paeoniae Radix Alba by UHPLC-Q-Exactive Orbitrap MS

Xiong, Pei; Qin, Shihan; Li, Kailin; Liu, Mingjuan; Zhu, Lian; Peng, J.; Shi, Silin; Tang, Sunv; Tian, Anmin; Cai, Wei

doi:10.1016/j.arabjc.2021.103398

Cited by 21 publications

(18 citation statements)

References 33 publications

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“…Alkaloids provide antioxidant, antidiabetic, antimicrobial, antiinflammatory, and anticancer (Kukulka-Koch and Widelski 2017;Singh et al 2021). Flavonoids show excellent antifungal activity (Ahmed et al 2017), besides tannins have antiinflammatory, and antioxidant pharmacological activity (Xiong et al 2021). Polyphenols have biological activity for antioxidants, antiinflammatory, antimicrobial, and antidiabetics (Lescano et al 2019).…”

Section: Discussionmentioning

confidence: 99%

Ethnobotany of traditional medicine in Dayak Jangkang Tribe, Sanggau District, West Kalimantan, Indonesia

et al. 2021

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Abstract. Supiandi MI, Ege B, Julung H, Zubaidah S, Mahanal S. 2021. Ethnobotany of traditional medicine in Dayak Jangkang Tribe, Sanggau District, West Kalimantan, Indonesia. Biodiversitas 22: 5417-5424. The Dayak Jangkang tribe has local knowledge about the use of medicinal plants that have been going on for a long time. Unfortunately, the local knowledge of the Dayak Jangkang tribe is currently threatened to disappear because it is delivered orally; there are no written documents and a wasteful lifestyle. The study aimed to document traditional medicinal plants that are utilized by the Dayak Jangkang tribe. The research approach used was qualitative descriptive using the field survey. The study interviewed three informants categories, i.e., the main informant (one customary chairman), key informant (one village head), and recommended informant (eight people who were knowledgeable about medicinal plants). The data were obtained through in-depth interviews and participatory observations. Data analysis used qualitative descriptive. The study got 40 plants that are used for traditional medicine with Zingiberaceae as the most used family. The parts of plants used by the Dayak Jangkang tribe for treatments were roots, bulbs, rhizomes, stems, bark, banana hump, fruit, fruit skins, leaves, fruit, and seeds. The mode of preparation is still considered simple.

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Section: Discussionmentioning

confidence: 99%

Ethnobotany of traditional medicine in Dayak Jangkang Tribe, Sanggau District, West Kalimantan, Indonesia

et al. 2021

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“…The product ions at m / z 169.0133 and 125.0232 indicated the presence of gallic acid. Therefore, compounds 3 and 7 were determined to be a 1-galloyl-β-glucose isomer [ 4 ].…”

Section: Resultsmentioning

confidence: 99%

“…Traditional Chinese medicine preparation (TCMP) has a long history in medical practice and health care, particularly in Asian and African countries. TCMP has attracted considerable attention in great many fields due to its effective therapeutic performance and low toxicity [ 3 , 4 ]. With the development of analytical techniques, the combination of ultra-high-performance liquid chromatography and mass spectrometry (UHPLC/MS) has had a significant impact on TCMP development in recent years [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Qualitative Analysis of Multiple Phytochemical Compounds in Tojapride Based on UHPLC Q-Exactive Orbitrap Mass Spectrometry

et al. 2022

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Tojapride is composed of Caulis Perillae, Rhizoma Cyperi, Radix Glycyrrhizae, Citrus aurantium L., Coptis chinensis Franch, Pericarpium Citri Reticulatae, Reynoutria japonica Houtt, Tetradium ruticarpum, and Cleistocactus sepium. It has the effects of inhibiting gastric acid and relieving pain. It is clinically used for treating gastroesophageal reflux disease. To further study the pharmacodynamic properties of Tojapride, the systematic characterization of the chemical constituents in Tojapride was investigated using ultra-performance liquid chromatography with Q-Exactive Orbitrap mass spectrometry combined with parallel reaction monitoring for the first time. Eventually, a total of 222 compounds, including flavonoids, alkaloids, and glycyrrhizic acid derivatives, were identified based on the chromatographic retention times, MS/MS2 information, and bibliography data; a total of 218 of these were reported for the first time as being present in Tojapride. This newly developed approach provides a powerful tool for extending our understanding of chemical constituents of Tojapride, which can be further extended to other TCMP composition research.

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“…Peak 12 was suggested as dimethyl gallic acid resulting from the MS/MS ions at 169 and 172 (26). Peak 11 was identified as tetragalloylglucose, with the MS/MS ions at 617 and 169 indicating the presence of 1 and 3 galloyl moieties (29). Peaks 14, 16, 17, and 19 showed the same MS ion and molecular formula and were tentatively identified as galloylpaeoniflorin and its isomers.…”

Section: Tanninsmentioning

confidence: 99%

Hypoglycemic and H2O2-induced oxidative injury protective effects and the phytochemical profiles of the ethyl acetate fraction from Radix Paeoniae Alba

Zhang

Peng²,

Wang³

et al. 2023

Front. Nutr.

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Radix Paeonia Alba (RPA) is often used as food and medicine. This study aimed to enrich and identify the antioxidant and hypoglycemic bioactive compounds from RPA. The results indicated that the ethyl acetate fraction (EAF) showed the highest total phenolic content, DPPH, ABTS+ scavenging ability, and α-glucosidase inhibition ability (IC50 = 7.27 μg/ml). The EAF could alleviate H2O2-induced oxidative stress in HepG2 cells by decreasing the MDA and ROS levels, improving cell apoptosis, increasing the enzyme activity of GPX-Px, CAT, SOD, Na+/K+-ATP, and Ca2+/Mg2+-ATP, and stimulating T-AOC expression, which also enhanced the glucose uptake of insulin-resistant HepG2 cells. In addition, the EAF significantly reduced the fasting blood glucose level and improved glucose tolerance in diabetic mice. An HPLC-QTOF-MS/MS analysis displayed that procyanidin, digallic acid isomer, methyl gallate, tetragalloylglucose isomer, dimethyl gallic acid, and paeoniflorin were the major compounds in the EAF. These findings are meaningful for the application of the EAF in the medicinal or food industry to prevent and treat oxidative stress and diabetes mellitus.

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Identification of the tannins in traditional Chinese medicine Paeoniae Radix Alba by UHPLC-Q-Exactive Orbitrap MS

Cited by 21 publications

References 33 publications

Ethnobotany of traditional medicine in Dayak Jangkang Tribe, Sanggau District, West Kalimantan, Indonesia

Ethnobotany of traditional medicine in Dayak Jangkang Tribe, Sanggau District, West Kalimantan, Indonesia

Qualitative Analysis of Multiple Phytochemical Compounds in Tojapride Based on UHPLC Q-Exactive Orbitrap Mass Spectrometry

Hypoglycemic and H2O2-induced oxidative injury protective effects and the phytochemical profiles of the ethyl acetate fraction from Radix Paeoniae Alba

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