Identification of the vibrational spectra of apigenin and luteolin

Шагаутдинова, И. Т.; Él'kin, M. D.; Лихтер, А. М.

doi:10.1134/s1027451015040175

Cited by 4 publications

(3 citation statements)

References 7 publications

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“…All these characteristics peaks of APG were due to the intermolecular interaction between the carbonyl and hydroxyl groups. These interactions were originated from the high electronegativity of oxygen forcing a hydrogen bonding with the hydroxyl group (Huang et al, 2013; Shagautdinova et al, 2015, Telange et al, 2017). The stretching vibrational peaks of APG were also presented in the SDs prepared by different techniques, suggesting no change in the chemical structure of APG during the formation of SDs (Zhang et al, 2013).…”

Section: Resultsmentioning

confidence: 99%

Dissolution and bioavailability improvement of bioactive apigenin using solid dispersions prepared by different techniques

Alshehri

Shakeel

Ibrahim

et al. 2019

Saudi Pharmaceutical Journal

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Apigenin (APG) is a poorly soluble bioactive compound/nutraceutical which shows poor bioavailability upon oral administration. Hence, the objective of this research work was to develop APG solid dispersions (SDs) using different techniques with the expectation to obtain improvement in its in vitro dissolution rate and in vivo bioavailability upon oral administration. Different SDs of APG were prepared by microwave, melted and kneaded technology using pluronic-F127 (PL) as a carrier. Prepared SDs were characterized using “thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), Fourier transform infra-red (FTIR) spectrometer, powder X-ray diffraction (PXRD) and scanning electron microscopy (SEM)”. After characterization, prepared SDs of APG were studied for in vitro drug release/dissolution profile and in vivo pharmacokinetic studies. The results of TGA, DSC, FTIR, PXRD and SEM indicated successful formation of APG SDs. In vitro dissolution experiments suggested significant release of APG from all SDs (67.39–84.13%) in comparison with control (32.74%). Optimized SD of APG from each technology was subjected to in vivo pharmacokinetic study in rats. The results indicated significant improvement in oral absorption of APG from SD prepared using microwave and melted technology in comparison with pure drug and commercial capsule. The enhancement in oral bioavailability of APG from microwave SD (319.19%) was 3.19 fold as compared with marketed capsule (100.00%). Significant enhancement in the dissolution rate and oral absorption of APG from SD suggested that developed SD systems can be successfully used for oral drug delivery system of APG.

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Section: Resultsmentioning

confidence: 99%

Dissolution and bioavailability improvement of bioactive apigenin using solid dispersions prepared by different techniques

Alshehri

Shakeel

Ibrahim

et al. 2019

Saudi Pharmaceutical Journal

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“…This peak could represent the C=O that exists in the B ring of API [ 18 ]. Also, OH bending (βOH) was attributed to this region in API spectra [ 19 ]. The higher intensity of this band for solid API compare to Api@AuNPs could be a proof of interaction of API with gold nanoparticles surface through the hydroxyl or carbonyl group of the molecule.…”

Section: Resultsmentioning

confidence: 99%

“…The higher intensity of this band for solid API compare to Api@AuNPs could be a proof of interaction of API with gold nanoparticles surface through the hydroxyl or carbonyl group of the molecule. At the right shoulder of this broad peak, another peak appeared around 1600–1620 cm −1 that could represent the vibrational mood of C=O or C=C in API the molecule [ 14 , 19 ]. A distinguished double band at 945 and 1005 cm −1 and very strong peaks at 600–700 cm −1 was attributed to phenyl ring chain and carbonyl vibrations which were appeared only for solid API samples.…”

Section: Resultsmentioning

confidence: 99%

Investigating the in vitro photothermal effect of green synthesized apigenin‐coated gold nanoparticle on colorectal carcinoma

Amini

Mohammadi

Askarian‐Amiri

et al. 2021

IET Nanobiotechnology

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Applying toxic chemical to the synthesis of stable gold nanoparticles is one of the limitations of gold nanoparticles for therapeutic applications such as photothermal therapy. Plant compounds such as apigenin (API) with therapeutic potential can be applied in the synthesis of gold nanoparticles. API-coated gold nanoparticles (Api@AuNPs) with an average size of 19.1 nm and a surface charge of À 4.3 mV have been synthesized by a simple and efficient technique. The stability of Api@AuNPs in the biological environment was verified through UV-Vis spectroscopy. Based on Raman and FTIR spectroscopy analysis, chemical binding of API on the surface of Api@AuNPs through hydroxyl and carbonyl functional groups was found to be the main reason for the stability of the Api@AuNPs in comparison with citrate-coated gold nanoparticles (Cit@AuNPs). The synthesized Api@AuNPs do not cause major toxic effects up to 128 ppm. Api@AuNPmediated photothermal therapy leads to the indiscriminate eradication of almost half of both mouse fibroblastic (L929) and colorectal cancer (CT26) cells. Flow-cytometry analysis revealed that the cell death mechanism is mainly apoptosis. In the apoptosis triggered cell death in photothermal treatment, Api@AuNPs are preferred over commonly used gold nanoparticles in photothermal treatments which mostly trigger the necrosis cell death pathway. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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