Identification of TRPV4 as a novel target in invasiveness of colorectal cancer

Zhang, Peng; Xu, Jian; Zhang, Hua; Liu, Xiaoyu

doi:10.1186/s12885-021-08970-7

Cited by 17 publications

(14 citation statements)

References 35 publications

(46 reference statements)

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“…Accordingly, TRPV4 overexpression is associated with poor prognosis in glioma patients ( Ou-Yang et al, 2018 ; Yang et al, 2020b ). In line with these studies, TRPV4 overexpression increases the migration and invasion of colon cancer cells by activating Akt ( Zhang et al, 2021 ). Silencing or inhibiting TRPV4 suppresses invasiveness by abrogating ZEB1-mediated EMT ( Zhang et al, 2021 ).…”

Section: Introductionmentioning

confidence: 66%

“…Similarly, Piezo2 can regulate focal adhesion dynamics via Fyn kinase and calpain activity and promote stress fiber assembly through RhoA/mDia ( Pardo-Pastor et al, 2018 ). TRP channels have also been shown to regulate focal adhesion dynamics by activating calpain, FAK and PI3K/Akt signaling ( Sun et al, 2014a ; Wang et al, 2014 ; Cáceres et al, 2015 ; Mrkonjić et al, 2015 ; Lee et al, 2017a ; Azimi et al, 2017 ; Ou-Yang et al, 2018 ; Almasi et al, 2019 ; Li et al, 2020b ; Sun et al, 2021 ; Zhang et al, 2021 ). For instance, TRPV4 knockdown reduces calpain activity, which prevents focal adhesion disassembly and leads to the formation of large adhesions that anchor the cell ( Mrkonjić et al, 2015 ).…”

Section: Concluding Remarks and Future Outlookmentioning

confidence: 99%

“…Moreover, TRP channels can regulate actin dynamics and stimulate cellular contractility by activating Rac, RhoA/myosin-II, RhoA/ROCK1/LIMK/cofilin or calmodulin/IQGAP/Cdc42 ( Adapala et al, 2016 ; Li et al, 2020c ; Yankaskas et al, 2021 ). Additionally, TRPC1, TRPC5, TRPM2, TRPM4, TRPM7, TRPV2 and TRPV4 can independently induce EMT in cancer cells ( Chen et al, 2017a ; Azimi et al, 2017 ; Chen et al, 2017b ; Almasi et al, 2019 ; Liu et al, 2019b ; Kudou et al, 2019 ; Sagredo et al, 2019 ; Su et al, 2019 ; Yang et al, 2020a ; Li et al, 2020b ; Zhang et al, 2021 ; Kato et al, 2022 ).…”

Section: Concluding Remarks and Future Outlookmentioning

confidence: 99%

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The interplay between physical cues and mechanosensitive ion channels in cancer metastasis

Bera

Kiepas

Zhang

et al. 2022

Front. Cell Dev. Biol.

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Physical cues have emerged as critical influencers of cell function during physiological processes, like development and organogenesis, and throughout pathological abnormalities, including cancer progression and fibrosis. While ion channels have been implicated in maintaining cellular homeostasis, their cell surface localization often places them among the first few molecules to sense external cues. Mechanosensitive ion channels (MICs) are especially important transducers of physical stimuli into biochemical signals. In this review, we describe how physical cues in the tumor microenvironment are sensed by MICs and contribute to cancer metastasis. First, we highlight mechanical perturbations, by both solid and fluid surroundings typically found in the tumor microenvironment and during critical stages of cancer cell dissemination from the primary tumor. Next, we describe how Piezo1/2 and transient receptor potential (TRP) channels respond to these physical cues to regulate cancer cell behavior during different stages of metastasis. We conclude by proposing alternative mechanisms of MIC activation that work in tandem with cytoskeletal components and other ion channels to bestow cells with the capacity to sense, respond and navigate through the surrounding microenvironment. Collectively, this review provides a perspective for devising treatment strategies against cancer by targeting MICs that sense aberrant physical characteristics during metastasis, the most lethal aspect of cancer.

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Section: Introductionmentioning

confidence: 66%

Section: Concluding Remarks and Future Outlookmentioning

confidence: 99%

Section: Concluding Remarks and Future Outlookmentioning

confidence: 99%

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The interplay between physical cues and mechanosensitive ion channels in cancer metastasis

Bera

Kiepas

Zhang

et al. 2022

Front. Cell Dev. Biol.

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“…Small interfering RNA (siRNA) and overexpressed plasmids were customized by Genomeditech Co., Ltd. (Shanghai, China) and transfected into HNSCC cells using Lipofectamine®3000 (Invitrogen; Thermo Fisher Scientific, Inc.) according to the manufacturer’s instructions[ 11 ], and the transfection efficiency was validated by qPCR. Cells were used for further experiments 48 h after transfection.…”

Section: Methodsmentioning

confidence: 99%

Long non-coding RNA human leucocyte antigen complex group-18 HCG18 (HCG18) promoted cell proliferation and migration in head and neck squamous cell carcinoma through cyclin D1-WNT pathway

Mu¹,

Wang²,

Zhang³

et al. 2022

Bioengineered

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Emerging evidence has demonstrated that long noncoding RNA (lncRNAs) play a vital role in the development of head and neck squamous cell carcinoma (HNSCC); however, the biological effects and underlying mechanisms of human leukocyte antigen complex group-18 HCG18 (HCG18) have not yet been reported in HNSCC. In this study, we detected the expression of the HCG18 in HNSCC cell lines and patient tissues. We observed that HCG18 was upregulated in HNSCC patient tissues and cell lines. Furthermore, silencing of HCG18 significantly inhibited proliferation, migration, and invasion of HNSCC cells, whereas the opposite effects were detected in the HCG18-overexpressed group. We also found that HCG18 directly binds to the functional protein cyclin D1. Upregulated cyclin D1 reversed the inhibitory effects of HCG18 in HNSCC cell lines and activated the WNT pathway-related proteins (AXIN2, survivin, c-Myc, and β-catenin) simultaneously. Knockdown of cyclin D1 could accelerate the inhibitory effects of HCG18 and decrease the expression of AXIN2, survivin, c-Myc, and β-catenin. This indicated that lncRNA HCG18 might be involved in the tumorigenesis of HNSCC via the cyclin D1-WNT pathway. These results suggest that lncRNA HCG18 could act as a promising prognostic biomarker and potential therapeutic target in HNSCC patients.

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“…For instance, TRP channels, such as TRPC1, TRPC5/6, TRPM4, TRPM7/8, TRPV1/2, TRPV4, and TRPV6 are closely associated with progression and act as novel therapeutic targets in breast invasive carcinoma ( 6 ). TRPV4 is also a proven immunomodulatory related prognostic biomarker in ovarian cancer and colorectal cancer ( 7 , 8 ). In addition, TRPM8 is a potential therapeutic target in prostate adenocarcinoma ( 9 ), colon adenocarcinoma ( 10 ), breast invasive carcinoma ( 11 ), and bladder urothelial carcinoma ( 12 ).…”

Section: Introductionmentioning

confidence: 99%

The Pan-Cancer Landscape of Crosstalk Between TRP Family and Tumour Microenvironment Relevant to Prognosis and Immunotherapy Response

Yin

et al. 2022

Front. Immunol.

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BackgroundTransient Receptor Potential (TRP) channel is a kind of channel protein widely distributed in peripheral and central nervous system. They can be regulated by natural aromatic substances and serve as a therapeutic target for many diseases. However, the role and function of the TRP family genes in tumours remain unclear.MethodsGene alterations (mutation, copy number, methylation), expression, clinical features, and prognostic value of the TRP family genes were evaluated in pan-cancer using data from The Cancer Genome Atlas and Genotype-Tissue Expression databases. TRP score was calculated by the ssGSEA function of the R package “GSVA”. The association of TRP score and the tumour microenvironment (TME), especially the tumour immune microenvironment (TIME), along with immunotherapy response were explored in-depth.ResultsTRP family genes were involved in tumour progression and highly associated with poor prognosis in a variety of cancers. TRP score was positively associated with malignant pathways in pan-cancer, such as IL6–JAK–STAT3 signalling, interferon-gamma response, and inflammatory response. All pathways were closely associated with TIME. Elevated TRP score also correlated with multiple immune-related characteristics of the TIME in pan-cancer. Moreover, the TRP score was a predictive biomarker for immune checkpoint inhibitor (ICI) treatments in patients with tumours.ConclusionsTRP family genes play a key role in pan-cancer and are closely associated with TME. Patients with high TRP scores have excellent immune-activated TIME and immunotherapy sensitivity. Therefore, the TRP score could be a potential biomarker for patients with tumours treated with ICI.

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Identification of TRPV4 as a novel target in invasiveness of colorectal cancer

Cited by 17 publications

References 35 publications

The interplay between physical cues and mechanosensitive ion channels in cancer metastasis

The interplay between physical cues and mechanosensitive ion channels in cancer metastasis

Long non-coding RNA human leucocyte antigen complex group-18 HCG18 (HCG18) promoted cell proliferation and migration in head and neck squamous cell carcinoma through cyclin D1-WNT pathway

The Pan-Cancer Landscape of Crosstalk Between TRP Family and Tumour Microenvironment Relevant to Prognosis and Immunotherapy Response

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