Identification of tyrosinase inhibitors from Marrubium velutinum and Marrubium cylleneum

Karioti, Anastasia; Protopappa, Anastasia; Megoulas, Nikolaos C.; Skaltsa, Helen

doi:10.1016/j.bmc.2007.01.035

Cited by 138 publications

(93 citation statements)

References 28 publications

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“…Compound 7 was identified as (+) syringaresinol by comparing its NMR data with those available in the literature [12]. Compound 8 was identified as apigenin 7-O-β-D(-3′′,6′′-p-E-dicoumaroyl)-glucoside, Anisofolin A, by comparing its spectral data with those available in literature [13][14][15]. Compound 9 was identified as apigenin 7-O-β-D-(-6′′-p-E-coumaroyl)-glucoside by comparing its spectral data with the literature [16,17].…”

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confidence: 99%

Leucas mollissima, a Source of Bioactive Compounds with Antimalarial and Antimycobacterium Activities

et al. 2015

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!A phytochemical investigation of the acetone extract from the aerial parts of Leucas mollissima afforded one new (−)epi-marmelo lactone, (2 S, 4R, 6 S)-2,6-dimethyl-6 hydroxy-7-ene-4-olide (1), along with five known compounds, schensianol A (2), vanillin (3), β-hydroxy propiovanillone (4), lanost-9(11),25-diene-3β,24β-diol (5), and lanost-9(11),23E(24)-diene-3β,25-diol (6). Similarly, an investigation of the methanol extract of the aerial parts of L. mollissima resulted in the isolation of three known compounds, (+)-syringaresinol (7), anisofolin A (8), and apigenin 7-O-β-D(− 6′′-p-E-coumaroyl)-glucoside (9). Structure elucidation of the isolated compounds was carried out using detailed analysis of 1D and 2D nuclear magnetic resonance. All compounds were evaluated for antimalarial activity against Plasmodium falciparum (3D7) and for antimycobacterium activity against Mycobacterium tuberculosis H37Ra and Mycobacterium bovis. Compound 8 was found to have promising antimalarial activity (IC 50 4.39 ± 0.25 µM), promising antimycobacterium activity [IC 50 4.50 ± 0.75 µM (3.31 µg/mL)] against M. tuberculosis H37Ra and at 100 µg/mL, showed 55.6 % inhibition of M. bovis. Compound 9 showed moderate inhibition of P. falciparum growth (35% inhibition at 10 µM) with respect to the positive control atovaquone and 67.4 % inhibition against M. bovis at 100 µg/mL with respect to the positive control rifampicin.

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confidence: 99%

Leucas mollissima, a Source of Bioactive Compounds with Antimalarial and Antimycobacterium Activities

et al. 2015

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“…In the past few decades, a number of polyphenol tyrosinase inhibitors from both natural and synthetic sources, including flavonoids, stilbenes, and terpenoids, have been intensively investigated 10 . Estimation of total phenolics, alkaloids and tannic acid indicated that all the three extracts which showed higher tyrosinase inhibition also had higher concentration of alkaloids, tannins and phenolics (Table 2).…”

Section: Resultsmentioning

confidence: 99%

“…Petroleum ether extract contains fats and fixed oil while aqueous extract contains amino acids, tannins (condensed and pseudo tannins) and starch [5]. IR has been reported to possess various pharmacological actions, mainly antidiabetic [6], antiinflammatory [7], nephroprotective [8], antibacterial [9], antioxidant and antimicrobial activity [10]. Further, the principle constituents of IR such as sinapic and ferulic acids have exhibited behavioural and pharmacological…”

Section: Introductionmentioning

confidence: 99%

Preliminary Screening of Selected Plant Extracts for Anti Tyrosinase Activity

Vidyalakshmi¹,

Sahithya²

2016

JNR

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Tyrosinase inhibition is an important approach towards controlling hyper pigmentation. We aimed to screen alcoholic extracts of 11 plants extract for their tyrosinase inhibitory activity. These plants have been used traditionally in the treatment of skin ailments and for the improvement of skin complexion. The extracts were quantified for total phenols, alkaloids and tannins. In vitro tyrosinase inhibition was performed with kojic acid as the positive control. Cell viability was tested on B16 F0 melanoma cells. The extracts of Rosa berberifolia, Punica granatum and Casiia angustifolia showed more than 80% inhibition at 500 mg/ml concentration. Nine of the extracts were also shown to have a high phenolic content greater than 200 mg/g of the plant material. The tyrosinase inhibitory activity of the extracts of Cassia angustifolia, Punica granatum and Rosa berberifolia were comparable with that of the control, kojic acid. The three extracts also showed lesser than 50% cytotoxicity at the concentrations tested. From the screening assays, it is seen that three plants have appreciable tyrosinase inhibitory activity. Hence, these plants may be further evaluated for their use in cosmetics and hyper pigmentation. Preliminary Screening of Selected PlantExtracts for Anti Tyrosinase Activity JOURNAL OF NATURAL REMEDIES AbstractIpomoea reniformis Chaos is claimed in Indian traditional medical practice to be useful in the treatment of epilepsy and neurological disorders. In the present study, pretreatment effect of methanolic extract of Ipomoea reniformis on epilepsy and psychosis was evaluated in rodents using standard procedures. Besides evaluating epileptic and behavioral parameters, neurotransmitters such as Gamma-Amino Butyric Acid (GABA) in epilepsy and in psychosis dopamine, noradrenaline and serotonin contents in the rodent brain were estimated. The extract pretreatment reduced maximal electro shock; Isoniazid (INH) and Pentylenetetrazole (PTZ) induced seizures and also significantly inhibited the attenuation of brain GABA levels by INH and PTZ in mice. These results suggested that the observed beneficial effect in epilepsy may be by enhancing the GABAergic system. The test drug also inhibited the apomorphine induced climbing and stereotyped behavior and showed significantly reduced levels of brain dopamine, noradrenaline and serotonin which may be due to blocking of central dopaminergic, noradrenergic and serotonergic pathways or by enhancing the GABAergic system. The results obtained in present study suggest that the title plant possesses antiepileptic and antipsychotic activities in rodents.

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“…13 In brief, 100 μL of the mushroom tyrosinase (9.63 unit/mL) in 25 mM potassium phosphate buffer (pH 6.8) was added to 50 μL of the different concentrations of the extracts (1.67, 0.83, 0.42, 0.21, 0.10 and 0.05 mg/mL). After incubation at the room temperature for five min, 100 μL of L-DOPA (2.5 mM) in 25 mM potassium phosphate buffer (pH 6.8) was added to a 96-well plate in a total volume of 250 μL.…”

Section: Tyrosinase Inhibitory Assaymentioning

confidence: 99%

Inhibitory Effects of Urginea maritima (L.) Baker, Zhumeria majdae Rech. F. and Wendelbo and Physalis divaricata D. Don Ethanolic Extracts on Mushroom Tyrosinase

Namjoyan¹,

Jahangiri²,

Azemi³

et al. 2016

Pharm Sci

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Identification of tyrosinase inhibitors from Marrubium velutinum and Marrubium cylleneum

Cited by 138 publications

References 28 publications

Leucas mollissima, a Source of Bioactive Compounds with Antimalarial and Antimycobacterium Activities

Leucas mollissima, a Source of Bioactive Compounds with Antimalarial and Antimycobacterium Activities

Preliminary Screening of Selected Plant Extracts for Anti Tyrosinase Activity

Inhibitory Effects of Urginea maritima (L.) Baker, Zhumeria majdae Rech. F. and Wendelbo and Physalis divaricata D. Don Ethanolic Extracts on Mushroom Tyrosinase

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