Identification of unprecedented purine-containing compounds, the zingerines, from ginger rhizomes (Zingiber officinale Roscoe) using a phase-trafficking approach

Araya, Juan J.; Zhang, Huaping; Prisinzano, Thomas E.; Mitscher, Lester A.; Timmermann, Barbara N.

doi:10.1016/j.phytochem.2011.03.007

Cited by 14 publications

(5 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A total of 100 bioactive constituents obtained from extensive literature research were selected to perform the molecular docking studies to screen and identify the potent antiviral agents for COVID-19. Left as it follows; 15, 16, 16, 3, 32 and 19 on Zingiber officinale (Zingiberaceae) [17][18][19], Cymbopogon citratus (Poaceae) [20][21][22], Allium cepa [23][24][25][26][27], Allium sativum L. (Alliaceae) [28], Citrus sinensis (Rutaceae) [29][30][31] and Thymus vulgaris [32][33][34] (Lamiaceae), respectively. ChemSketch Software was used to prepare the PDB ligands structures.…”

Section: Phytochemicals Dataset and Ligand Preparationmentioning

confidence: 99%

Targeting the Main Protease and the Spike Protein of Sars-Cov-2 With Naturally Occurring Compounds From Some Cameroonian Medicinal Plants: An in-Silico Study for Drug Designing

Fouedjou

Fogang

Ouassaf

et al. 2022

J. Chil. Chem. Soc.

View full text Add to dashboard Cite

Despite the social distancing and hygiene rules prescribed by the WHO, the novel Corona-virus is still on the way of a significant rapid rise in deaths. Therefore, identification of chemotherapeutic drugs against Corona Viral Infection all around the world is still requires. Some medicinal plants have a valuable therapeutic effect when mixt with honey, the obtained formulations are preliminary use in Cameroon against viral infection particularly respiratory infections. In this work, we looked for the potential anti-SARS-CoV-2 molecule throw execution of in silico computational studies of six Cameroonian plants intervening in the treatment respiratory infections in apiphytotherapy. AutoDock Vina was used for docking studies against SARS-CoV-2 main protease (Mpro) and spike (SP) proteins. We further conducted of pharmacokinetics properties and the safety profile of compounds with the top score in order to identify the best drug candidates. Totally 100 compounds were screened, of these, eighteen showed high binding affinity against SARS-CoV-2 Mpro and SP. The results suggest the effectiveness of compounds 10 and 17 obtained from Citrus Sinensis as potent drugs against SARS-CoV-2 as they tightly bind to its Mpro and SP with low binding energies. The stability of the two compounds complexed with Mpro and SP was validated through MD simulation. The availability of potent protein inhibitors and diverse of compounds from Cameroon flora scaffolds indicate the feasibility of developing potent Mpro and SP proteins inhibitors as antivirals for COVID-19. Based on further in vivo and in vitro experiments and clinical trials, some of these phytoconstituents could be proposed for effective inhibition of the replication of the SARS-CoV-2.

show abstract

Section: Phytochemicals Dataset and Ligand Preparationmentioning

confidence: 99%

Targeting the Main Protease and the Spike Protein of Sars-Cov-2 With Naturally Occurring Compounds From Some Cameroonian Medicinal Plants: An in-Silico Study for Drug Designing

Fouedjou

Fogang

Ouassaf

et al. 2022

J. Chil. Chem. Soc.

View full text Add to dashboard Cite

show abstract

“…102 Three unprecedented purine alkaloids, named [6]-, [8]-, and [10]zingerines 137-139 have been isolated from the methanoic extract of ginger rhizomes (Zingiber officinale Roscoe) using a phase trafficking-based method. 103 A new purine derivative, 3-(3-methylbut-2-en-1-yl)isoguanine 140, and a new cleistanthane-type diterpenoid glucoside, together with eight known compounds have been isolated from the whole plant of Phyllanthus reticulates. 104 Chemical investigation of the bioactive fractions of the mycelia of Cordyceps sinensis has led to isolation of ve constituents, cordysinins A-E, reported from a natural source for the rst time.…”

Section: Purine Alkaloidsmentioning

confidence: 99%

Muscarine, imidaozle, oxazole and thiazole alkaloids

Jin

2013

Nat. Prod. Rep.

134

View full text Add to dashboard Cite

Covering: July 2010 to June 2012. Previous review: Nat. Prod. Rep., 2011, 28, 1143-1191. Structurally diverse alkaloids containing five-membered heterocyclic subunits, such as imidazole, oxazole, thiazole, as well as their saturated congeners, are widely distributed in terrestrial and marine organisms and microorganisms. These naturally occurring secondary metabolites often exhibit extensive and pharmacologically important biological activities. The latest progress involving isolation, biological activities, chemical synthetic studies, and biosynthetic pathways of these natural products has been summarized in this review.

show abstract

“…It has the effect of inducing sweat and dispelling exogenous evils ,eliminating phlegm and relieving cough and warming middle energizer to arrest vomiting, is a commonly herb plant used in medicinal and edible [1].In addition to the nutritional components of, ginger also contains gingerol, shogaol, zingiberone, purine compounds, volatile oil components and other functional chemical components [2,3,4].The rhizome (dried ginger), cork (Jiang Pi) and leaf (Jiang Ye) of ginger can be used as medicine, it topical can alleviate rheumatic diseases, oral has the effects of antibacterial and anti-inflammatory . In Clinical, it can be used for the treatment of cold, diarrhea and vomiting, swelling, nasal congestion and other diseases.…”

Section: Introductionmentioning

confidence: 99%

Analysis on the Application and Characteristics of Chinese Patent Medicines Containing Ginger

Liu¹,

Bai²,

Miao³

2018

dtbh

View full text Add to dashboard Cite

Abstract. Ginger taste acrid flavor, slightly warm in nature, tropism of spleen, stomach and lung. Ginger has the effect of inducing sweat and dispelling exogenous evils, eliminating phlegm and relieving cough and warming middle energizer to arrest vomiting. Since ancient times, China has been saying that ginger can cure any diseases. In Zhou Qin's history, the cultivation, consumption and medical use of ginger were recorded in detail. With the continuous digging of ginger in edible and medicinal fields, the application of Chinese patent medicine containing ginger is also concerned all over the world. The research on ginger and its products has been the focus of people's attention, but the research and application of Chinese patent medicine containing ginger is less. This paper summarizes Chinese patent medicine containing ginger, analyzes its application and characteristics, provides theoretical basis for the use of Chinese patent medicine containing ginger.

show abstract

Identification of unprecedented purine-containing compounds, the zingerines, from ginger rhizomes (Zingiber officinale Roscoe) using a phase-trafficking approach

Cited by 14 publications

References 20 publications

Targeting the Main Protease and the Spike Protein of Sars-Cov-2 With Naturally Occurring Compounds From Some Cameroonian Medicinal Plants: An in-Silico Study for Drug Designing

Targeting the Main Protease and the Spike Protein of Sars-Cov-2 With Naturally Occurring Compounds From Some Cameroonian Medicinal Plants: An in-Silico Study for Drug Designing

Muscarine, imidaozle, oxazole and thiazole alkaloids

Analysis on the Application and Characteristics of Chinese Patent Medicines Containing Ginger

Contact Info

Product

Resources

About