Identifizierung der Eintragsquellen von Antibiotika in das Grundwasser viehstarker Regionen

Hannappel, Stephan; Kopp, C.; Zühlke, Sebastian; Balzer, Frederike; Schulz, D.

doi:10.1007/s00767-016-0339-7

Cited by 3 publications

(2 citation statements)

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“…Both species show absorption features within the transmission bands of the fiber used. Traces of SMX have already been detected in environmental water at many locations in Europe, America and Asia [ 2 , 3 , 28 , 29 ], whereas SS was chosen due to its pronounced absorption peak at a very central position of the UV transmission window of the water-filled ARHCF. The molar absorptivity, ε , at the relevant peak position amounts to 3600 L/(mol·cm) for SS (at 296 nm) [ 30 ] and approximately 16,700 L/(mol·cm) for SMX (at 265 nm).…”

Section: Methodsmentioning

confidence: 99%

“…The contamination of drinking water and water supplies by otherwise widely accepted substances, such as pharmaceuticals, forms one severe threat of our modern society. The presence of such substances presents unforeseen consequences for human health, such as direct intoxication or, even more severe, the formation of multi-resistant pathogens [ 1 , 2 , 3 , 4 ], potentially rendering currently used antibiotic treatments ineffective. These highly relevant issues define a clear need to develop low cost, straightforward-to-apply, but also highly sensitive, methods for water monitoring [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

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UV Absorption Spectroscopy in Water-Filled Antiresonant Hollow Core Fibers for Pharmaceutical Detection

Nissen

Doherty

Hamperl

et al. 2018

Sensors

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Due to a worldwide increased use of pharmaceuticals and, in particular, antibiotics, a growing number of these substance residues now contaminate natural water resources and drinking supplies. This triggers a considerable demand for low-cost, high-sensitivity methods for monitoring water quality. Since many biological substances exhibit strong and characteristic absorption features at wavelengths shorter than 300 nm, UV spectroscopy presents a suitable approach for the quantitative identification of such water-contaminating species. However, current UV spectroscopic devices often show limited light-matter interaction lengths, demand sophisticated and bulky experimental infrastructure which is not compatible with microfluidics, and leave large fractions of the sample analyte unused. Here, we introduce the concept of UV spectroscopy in liquid-filled anti-resonant hollow core fibers, with large core diameters and lengths of approximately 1 m, as a means to overcome such limitations. This extended light-matter interaction length principally improves the concentration detection limit by two orders of magnitude while using almost the entire sample volume—that is three orders of magnitude smaller compared to cuvette based approaches. By integrating the fibers into an optofluidic chip environment and operating within the lowest experimentally feasible transmission band, concentrations of the application-relevant pharmaceutical substances, sulfamethoxazole (SMX) and sodium salicylate (SS), were detectable down to 0.1 µM (26 ppb) and 0.4 µM (64 ppb), respectively, with the potential to reach significantly lower detection limits for further device integration.

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