Idiopathic diabetes insipidus in a Welsh pony

Antidiuretic response of a horse affected with pituitarypars intermediadysfunction to desmopressin acetate

“…Both forms of DI are rare in horses and ponies (Chenault 1969; Filar et al . 1971; Satish and Sastry 1978; Breukink et al . 1983; Vente and Wijsmuller 1983; Brashier 2006).…”

Water Homeostasis and Diabetes Insipidus in Horses

“…In a Welsh pony in which the condition was considered idiopathic, absence of an increase in plasma AVP concentration after water deprivation (compared with control ponies) further supported a diagnosis of neurogenic DI. 72 Acquired neurogenic DI secondary to encephalitis was supported by detection of hypothalamic inflammation at necropsy in another horse. 71 Next, a 10-day-old Fresian filly with very dilute urine (specific gravity 1.001) failed to increase urine specific gravity in response to limiting access to nursing its dam.…”

“…[71][72][73][74][75][76] Three well-documented cases of neurogenic DI have been described. [71][72][73] None of the affected animals could concentrate urine in response to water deprivation, but administration of exogenous AVP resulted in an increase in urine concentration and a decrease in urine volume. In a Welsh pony in which the condition was considered idiopathic, absence of an increase in plasma AVP concentration after water deprivation (compared with control ponies) further supported a diagnosis of neurogenic DI.…”

“…There have also been several reports of naturally occurring central DI in equids. [71][72][73][74][75][76] Three well-documented cases of neurogenic DI have been described. [71][72][73] None of the affected animals could concentrate urine in response to water deprivation, but administration of exogenous AVP resulted in an increase in urine concentration and a decrease in urine volume.…”

Clinical Approach to Commonly Encountered Problems

“…661,662 In both cases, the horses were unable to concentrate urine in response to water deprivation but responded to the administration of exogenous vasopressin with a decrease in urine volume and increase in urine concentration. Neurogenic diabetes insipidus appears to be rare in the horse, with two cases reported in the literature.…”