Idiopathic eosinophilic cholecystitis with cholelithiasis: a report of two cases

Abstract

ABSTRACTeosinophilic cholecystitis is a rare entity diagnosed on the basis of classical presentation of cholecystitis with presence of more than 90% eosinophilic infiltration within the gall bladder. The etiology of eosinophilic cholecystitis still remains obscure. However it is frequently associated with other more severe diseases like hypereosinophilic syndrome, eosinophilic-myalgia syndrome, parasitic infestations, few herbal medicines and certain drugs.we report two cases who presented with gall stone disease, which on histopathological evaluation was diagnosed as eosinophilic cholecystitis. Retrospective analysis of their case histories and investigation did not reveal any known etiology. These cases are being reported because of their rarity and to highlight the importance of complete workup to rule out other associated disorders that may be a manifestation of a more severe disease.

The Clinicopathologic Evaluation of Eosinophilic Cholecystitis: A Retrospective Observational Study in a Tertiary Care Center

“…When the infiltrate be formed of 50-75% eosinophils along with other inflammatory cells it is diagnosed as lympho-eosinophilic cholecystitis. [2,3,4] Similarly, in our study mostly transmural, dense, diffuse eosinophilic infiltrates and few lympocytes were seen in EC cases, histopathologically.…”

“…In some studies researchers found that patients with acalculous cholecystitis contain a higher percentage of eosinophils, histopathologicallly than in patients with gallstones. [2][3][4]7,11] In contrast, 78.9% of our cases had biliary stones and one of them had biliary mud.…”

“…Diagnosis is histological and performed after analysis of the surgical specimen. [1,2] It is characterized histologically by a marked infiltrate composed predominantly or almost exclusively of eosinophils. It is diagnosed when cellular infiltrate consists of more than 90% eosinophils.…”

“…It is diagnosed when cellular infiltrate consists of more than 90% eosinophils. [2] The eosinophils can infiltrate the mucosa, muscular layer, serosa or all of them. [3] There are only few case reports about EC in literature.…”

Laparoskopik kolesistektomi uygulanan olgularda safra kesesinin histopatolojik profili

“…Safra kesesi mukozasında diğer inflamatuvar hücreler ile birlikte %90'dan fazla eozinofilik infiltrasyonun bulunduğu olgular ise eozinofilik kolesistit olarak rapor edilmektedir ve kolesistektomi materyallerinin %20'ni oluşturmaktadır. Eozinofilik kolesistitin başlıca nedenleri hipereozinofilik sendrom, eosinofili-miyalji sendromu, parazitik enfeksiyonlar, bazı bitkisel ve diğer ilaçlardır [18,19]. Kronik kolesistitlerin mikroskopik özelliğe sahip bir diğer tipi ksantogranulomatöz kolesistittir.Makroskopik ve radyolojik olarak bazen malignite görüntüsü verebilir ve bu yüzden tanı sürecinde histopatoloji önem arz etmektedir [20].…”