IFN-γ+874 A/T polymorphism and cancer risk: An updated analysis based on 32 case-control studies

Liu, Fei; Li, Bo; Yue, Wei; Chen, Xi; Ma, Yu; Yan, Lvnan; Wen, Tianfu; Xu, Mingqing; Wang, Wentao; Yang, Jiayin

doi:10.1016/j.cyto.2011.06.017

Cited by 8 publications

(7 citation statements)

References 41 publications

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“…Of these studies, seven include CC type. This meta-analysis did not show any association between IFN-+874 A>T polymorphism and different cancer types [25].…”

Section: Discussioncontrasting

confidence: 59%

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Association of IL10-1082 and IFN-γ+874 Polymorphisms with Cervical Cancer among Tunisian Women

et al. 2014

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Objective. The aim of this study was to investigate the role of IL10-1082 and IFN-γ+874 polymorphisms in susceptibility to cervical cancer among Tunisian women. Study Design. The IL10-1082 and IFN-γ+874 polymorphisms were analyzed by ARMS-PCR in 160 healthy women and 122 with cervical cancer. The search for associations between those polymorphisms and cervical cancer was based on the χ2 test or Fisher's exact test. Results. The IFN-γ+874 polymorphism showed significant increased frequency of T allele in healthy controls compared with patients (OR = 0.71, 95% CI = 0.50–1.01, and P=0.0459) and individuals with homozygote IFN-γ+874 T/T genotype were at lesser risk of cervical cancer (OR = 0.53, 95% CI = 0.31–0.92, and P=0.015). However, carriers of allele have higher risk for developing cervical cancer (OR = 1.88, 95% CI = 1.09–3.24, and P=0.015). At the polymorphic nucleotide in position 1082 of the IL10 promoter, no differences were found between patients and controls subjects. Conclusion. Our study shows that the T/T genotype polymorphism of IFN-γ+874 T>A is a protective factor for cervical cancer among Tunisian women.

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“…Of these studies, seven include CC type. This meta-analysis did not show any association between IFN-+874 A>T polymorphism and different cancer types [25].…”

Section: Discussioncontrasting

confidence: 59%

“…As cytokine gene polymorphisms play a role in the immune response, several studies have investigated the association between cytokine gene polymorphisms and cancers. However, the results vary between population groups [25][26][27].…”

Section: Discussionmentioning

confidence: 92%

Association of IL10-1082 and IFN-γ+874 Polymorphisms with Cervical Cancer among Tunisian Women

et al. 2014

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“…IFN-c + 874T/A polymorphism coincides with a putative NF-jB binding site that may directly influence the production of IFN-c [16]. Previous studies have suggested that the IFN-c + 874T/A polymorphism may influence immune regulation and may be an important factor in HBV infection [5,6,33]. Many studies have investigated the role of the IFN-c + 874T/A polymorphism in chronic HBV infection [14,15,[17][18][19][20][21][22][23][24][25][26][27][28]; however, their results were inconsistent.…”

Section: Discussionmentioning

confidence: 99%

The interferon‐gamma (IFN‐γ) +874T allele reduces the risk of hepatitis B infection in an Asian population

Sun

Tang

2013

Journal of Viral Hepatitis

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Increasing evidence suggests that polymorphism of the interferon-gamma (IFN-γ) gene in the first intron at position +874 may be associated with chronic hepatitis B virus (HBV) infection and/or HBV clearance. However, the results of relevant studies have been inconsistent. To derive a more precise estimation of the association, we performed a meta-analysis. In total, 10 independent studies including 1661 chronic HBV-infected patients and 1142 controls were included in this meta-analysis. In studies following Hardy-Weinberg equilibrium (HWE), a significantly decreased risk of chronic HBV infection was associated with the IFN-γ + 874TT genotype in the overall population (TT vs AA: odds ratio (OR) = 0.714, 95% confidence interval (CI) = 0.526-0.969, P = 0.031) when compared with a spontaneously recovered population. Subgroup analysis by ethnicity revealed a similar association in Asian individuals (TT vs AA: OR = 0.706, 95% CI = 0.518-0.962, P = 0.028). Moreover, when compared with a healthy control group, the 874T allele was associated with a significant lower risk of chronic HBV infection in the overall populations (TA vs AA: OR = 0.439, 95% CI = 0.193-0.997, P = 0.049; TT + TA vs AA: OR = 0.475, 95% CI = 0.271-0.832, P = 0.009) and in Asian individuals (TA vs AA: OR = 0.862, 95% CI = 0.744-0.999, P = 0.048). In conclusion, the IFN-γ + 874TT genotype and 874T allele reduce the risk of chronic HBV infection in Asian individuals.

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“…IL‐4*590T represented the minor allele in the present study, as also reported in Europeans (Vairaktaris et al ., ; Yannopoulos et al ., ; Tindall et al ., ) but not in the Chinese (Zhu et al ., ). The available data do not suggest a consistent geo‐ethnic trend for the IFN‐G A874T allele frequencies (Liu et al ., ). The frequency of MCP‐1*2578G allele in our study population is higher than that reported in Europeans (Saenz‐Lopez et al ., ; Kruszyna et al ., ), while an opposite trend has been reported in Chinese subjects with MCP‐1*2578A being the minor allele (Chen et al ., ).…”

Section: Discussionmentioning

confidence: 97%

“…We were unable to detect a statistically significant association between MCP‐1 A2578G and IFN‐G A874T genotypes and the risk for breast cancer, although a trend towards increased risk in carriers of MCP‐1*2578GG and IFN‐G*874TT genotypes was suggested – especially in the younger age group (<40 years; Table ). Our observation related to IFN‐G A874T gene polymorphism is compatible with the conclusion of a meta‐analysis revealing an association between this polymorphism and risk for breast cancer (Liu et al ., ). Similarly, increased risk for carriers of MCP‐1*2578GG genotype has been reported in a study of patients with breast cancer from Poland (Kruszyna et al ., ).…”

Section: Discussionmentioning

confidence: 97%

Opposing effects of pro‐ and anti‐inflammatory cytokine gene polymorphisms on the risk for breast cancer in western Indian women: a pilot study

Joshi

Bhat

Hake

et al. 2013

Int J Immunogenetics

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In an earlier study, the genotypes associated with higher level of transforming growth factor-β1 (TGF-β1) were found to reduce the risk for breast cancer in western Indian women. This observation implied that gene polymorphisms affecting the levels of pro- and anti-inflammatory cytokines may influence the risk for breast cancer in this population. Hence, we performed genotyping for three more functional single-nucleotide polymorphisms (SNPs) responsible for variations in the levels of cytokines associated with inflammation. To that effect, polymorphisms in genes coding for IL-4 (IL-4 C-590T; rs2243250), IFN-γ (IFN-G A + 874T; rs2430561) and MCP-1 (MCP-1 A-2578G; rs1024611) were examined in premenopausal, healthy women (N = 239) and patients with breast cancer (N = 182) from western India. In carriers of the IL-4*590T allele, a reduced risk for the disease (dominant model; OR = 0.61, 95% CI 0.37-0.98) was seen similar to that seen in TGF-B1*10C carriers. An opposite trend was observed with respect to the alleles associated with higher expression of MCP-1 or IFN-γ. In individuals positive for three or more alleles associated with higher levels of either pro- or anti-inflammatory cytokines, an additive effect on the modulation of risk for the disease was evident (for TGF-B1 & IL-4, OR = 0.33, 95% CI 0.12-0.87; for IFN-G & MCP-1, OR = 2.29, 95% CI 0.95-5.51). In the context of contrasting observations in other populations, these results indicate a significant contribution of anti-inflammatory genotypes in the modulation of risk for breast cancer in western Indian women.

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IFN-γ+874 A/T polymorphism and cancer risk: An updated analysis based on 32 case-control studies

Cited by 8 publications

References 41 publications

Association of IL10-1082 and IFN-γ+874 Polymorphisms with Cervical Cancer among Tunisian Women

Association of IL10-1082 and IFN-γ+874 Polymorphisms with Cervical Cancer among Tunisian Women

The interferon‐gamma (IFN‐γ) +874T allele reduces the risk of hepatitis B infection in an Asian population

Opposing effects of pro‐ and anti‐inflammatory cytokine gene polymorphisms on the risk for breast cancer in western Indian women: a pilot study

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