IgA, IgG and IgM anti-blood group A antibodies induced by pneumococcal vaccine

Koskela, Pentti; Nurmi, T; Häivä, Veli‐Mies

doi:10.1016/0264-410x(88)90214-9

Cited by 12 publications

(9 citation statements)

References 11 publications

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“…The effect of immunization on blood group antibody production has been described in pneumococcal polysaccharide vaccine, where an A-like antigen stimulated anti-A IgG antibodies [30]. IgG antibodies are capable of crossing the placenta and pose a risk for hemolytic disease of the newborn in group O or B women pregnant with a fetus of group A or AB.…”

Section: Discussionmentioning

confidence: 99%

Lack of impact of ABO blood group or corresponding isoantibodies on the immune response after rabies vaccination

Buchta

Körmöczi

Heinze

et al. 2005

Wien Klin Wochenschr

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Demand for rabies hyperimmunoglobulin has increased recently, requiring optimization of vaccination schemes for immunized plasma donors. Possible resemblance of rabies vaccine to blood group antigens and consequential association of the immune response to rabies vaccine and blood group or corresponding isoantibodies has not yet been investigated. We analyzed antirabies antibodies after rabies vaccination and ABO blood group in 142 individuals, and isoantibody titers in 92 of those individuals. We did not find any correlation of the immune response with blood group or isoantibody levels. There was also no correlation with the sex of individuals, but there was a weak correlation between age and rabies-specific antibody level. Rabies vaccination schemes for immunized donors cannot be optimized on the basis of blood groups or isoantibody titers.

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Section: Discussionmentioning

confidence: 99%

Lack of impact of ABO blood group or corresponding isoantibodies on the immune response after rabies vaccination

Buchta

Körmöczi

Heinze

et al. 2005

Wien Klin Wochenschr

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“…Whether the gut microflora is the main source of antigen as has been suggested previously, 13,14 or whether also virus infections, vaccinations, and, in case of women, ABOincompatible pregnancies, contribute antigens that shape AnƟ-A IgG subclasses the anti-A and -B IgG response remains to be shown. [15][16][17] Even though we used a pool of 100 blood group O donors, it may be that a similarly sized pool of blood group O donors collected in another part of the world-where a dissimilar microflora is likely to exist-may have a different repertoire of chain type-specific anti-A and -B. ABO antibodies of the IgG class are mainly of the IgG1 and IgG2 subclass, with the former being the predominant one. 18 We have previously shown that those individuals among healthy blood donors that had chain type-specific anti-A and -B IgG, all had the IgG2 subclass.…”

Section: Discussionmentioning

confidence: 99%

“…1) were obtained from Dextra Laboratories. The A and B oligosaccharides were coupled to HSA (with a sixatom spacer) via an aminopropyl linker at a coupling density of 6 (A Type 1), 18 (A Type 2), 9 (A Type 3), 16…”

Section: Methodsmentioning

confidence: 99%

Adsorption of chain type–specific ABO antibodies on Sepharose‐linked A and B tetrasaccharides

et al. 2012

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“…A priori it was speculated that the rate of high‐titer units might demonstrate a predictable, repetitive, and perhaps seasonal pattern; that is, it might be possible to predict when peaks and troughs of high‐titer units will occur. This was based on the literature describing the changes that can occur in anti‐A and/or anti‐B titers following vaccination . Although there was variability in the high titer rates by month, year, and testing center, no periodicity in the occurrence of higher‐ and lower‐than‐average rates of high‐titer units was apparent.…”

Section: Discussionmentioning

confidence: 99%

Seasonal variability is not observed in the rates of high anti‐A and anti‐B titers in plasma, apheresis platelet, and whole blood units tested by different methods

et al. 2018

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BACKGROUND: ABO-incompatible platelet transfusions are common, and transfusions with ABOincompatible plasma are increasing with the use of group A plasma and group O whole blood (WB) in emergencies. Many centers screen blood products for anti-A and/or anti-B titers to help prevent hemolysis from ABO-incompatible transfusions, yet titer methods and definition of high titers are not standardized. STUDY DESIGN AND METHODS: This internationalmulticenter study collected data on anti-A and anti-B titer practices for plasma, apheresis platelet (AP), and WB units from January 2015 through December 2017 to determine the prevalence of high-titer units using local definitions. RESULTS:A total of 87,701 plasma, AP and WB units were screened for high-titer anti-A and/or anti-B. Hightiter detection rates for group A plasma ranged 0%-13.6%; group A AP 2.7%-9.3%; group O AP 2.3%-65.7%; and group O WB 6.4%-20.7%. At the one center that collected group B AP, the high-titer rate was 10.9%. High-titer rates varied from month to month, as well as between years for a given month. There was no clear pattern of when high-titer units were donated. CONCLUSION:The prevalence of high-titer plasma, AP, and WB units varies by titer method and local definition of high titer. Even at the lowest titer threshold of 50, a significant proportion of units had a high-titer antibody, although the clinical relevance of this finding needs further investigation. P latelet transfusions containing incompatible plasma are common practice in the United States, yet plasma transfusions have historically been provided in a strictly ABO-compatible manner. Recent transfusion and resuscitation practices have incorporated the use of group A plasma and group O whole blood (WB) to recipients of unknown blood group in bleeding emergencies, thereby creating situations in which an ABO incompatibility might exist. 1,2 ABBREVIATIONS: AHG = anti-human globulin; AP = apheresis platelet; WB = whole blood.From the

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IgA, IgG and IgM anti-blood group A antibodies induced by pneumococcal vaccine

Cited by 12 publications

References 11 publications

Lack of impact of ABO blood group or corresponding isoantibodies on the immune response after rabies vaccination

Lack of impact of ABO blood group or corresponding isoantibodies on the immune response after rabies vaccination

Adsorption of chain type–specific ABO antibodies on Sepharose‐linked A and B tetrasaccharides

Seasonal variability is not observed in the rates of high anti‐A and anti‐B titers in plasma, apheresis platelet, and whole blood units tested by different methods

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