IL-17A and IL-17F genes variants and susceptibility to childhood asthma in Tunisia

Maalmi, Haïfa; Beraies, Anissa; Charad, Rihab; Ammar, Jamel; Hamzaoui, Kamel; Hamzaoui, A.

doi:10.3109/02770903.2013.876647

Cited by 38 publications

(40 citation statements)

References 37 publications

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“…Omrane et al identified that rs2275913GG genotype could be considered as a protective factor against colon cancer (p=0.00001) with OR 3.77 (2.04-6.99) [18]. Maalmi et al observed a strong correlation between rs2275913G/A SNP and risk of asthma in Tunisian children [14]. Ocejo-Vinyals et al presented that rs2275913GG genotype was associated with increased susceptibility to pulmonary tuberculosis in northern Spain [17].…”

Section: Discussionmentioning

confidence: 96%

Genetic Variants of Interleukin 17A Are Functionally Associated with Increased Risk of Age-Related Macular Degeneration

Shao-ru

Liu

et al. 2014

Inflammation

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Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in elderly populations worldwide. Inflammation, among many factors, has been suggested to play an important role in AMD pathogenesis. Interleukin 17 (IL-17) is a proinflammatory cytokine that has been implicated in the pathogenesis of various autoimmune diseases. In the current study, we examined two single nucleotide polymorphisms (SNPs), rs2275913G/A and rs3748067C/T, in the IL-17A gene between AMD patients and healthy controls. Results showed that rs2275913AA genotype and rs3748067TT genotype were associated with increased susceptibility to AMD (hazard ratio [HR], 1.75; 95 % confidence interval [CI], 1.07 to 3.02; P=0.023, and HR, 2.12; 95 % CI, 1.26 to 4.01; P=0.004; data were adjusted for age and sex). Next, we investigated the functional relevance of the two SNPs. In vitro stimulated peripheral blood mononuclear cells (PBMCs) from subjects possessing the rs2275913AA genotype produced significantly more IL-17 than those with the GG genotype. However, PBMCs with rs3748067TT genotype revealed significantly higher IL-17 production than those with rs3748067CC genotype only in AMD patients but not in controls. These data indicate IL-17A polymorphisms are associated with increased risk of AMD probably by affecting gene expression.

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Section: Discussionmentioning

confidence: 96%

Genetic Variants of Interleukin 17A Are Functionally Associated with Increased Risk of Age-Related Macular Degeneration

Shao-ru

Liu

et al. 2014

Inflammation

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“…Multiple previous studies have reported an association between IL-17 gene polymorphisms and autoimmune diseases (Jin et al, 2011;Zhang et al, 2013;Maalmi et al, 2014;Shen et al, 2015). Jin et al (2011) reported an association between IL-17 gene polymorphisms and susceptibility to asthma in a Korean population, and suggested that the rs1889570 polymorphism was correlated with the development of asthma.…”

Section: Discussionmentioning

confidence: 99%

“…Shen et al (2015) reported that the IL-17 rs2275913 and rs3819024 variant alleles were associated with a decreased risk of rheumatoid arthritis, while the IL-17 rs3819025 and rs8193036 variant alleles were correlated with an increased risk of rheumatoid arthritis. Maalmi et al (2014) conducted a study in a Tunisian population, and found that the IL-17A rs2275913 and IL-17F rs763780 were associated with an increased risk of asthma in children. Zhang et al (2013) examined the association between IL-17 gene polymorphisms and inflammatory bowel disease, and reported that the IL-17 rs2275913 and rs763780 polymorphisms were associated with an increased risk of inflammatory bowel disease.…”

Section: Discussionmentioning

confidence: 99%

Influence of interleukin-17 gene polymorphisms on the development of pulmonary tuberculosis

Shi¹,

Zhang²

2015

Genet. Mol. Res.

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ABSTRACT. We conducted a case-control study in a Chinese population to examine the correlations between interleukin (IL)-17 gene polymorphisms and tuberculosis (TB) development. The study population included 336 TB subjects and 351 control subjects who were enrolled between June 2012 and June 2014. Genotyping analyses of IL-17A rs2275913 and rs3748067 and IL-17F rs763780 were analyzed using polymerase chain reaction-restriction fragment length of polymorphism. The genotype distributions of IL-17 rs2275913 were found to be in Hardy-Weinberg equilibrium in the controls, while the IL-17 rs3748067 and rs763780 were not. Based on unconditional logistic regression, individuals carrying the AA genotype and GA + AA genotype of rs2275913 were more likely to have a significantly increased risk of TB compared to subjects with the GG genotype. The ORs (95%CI) for the AA genotype and GA + AA genotype were 2.20 (1.35-3.60) and 1.52 (1.11-2.09), respectively. The CC genotype and TC + CC genotype of rs763780 were associated with increased risk of TB when compared with the TT genotype. The ORs (95%CI) for the CC genotype and TC + CC genotype were 1.99 (1.05-3.87) and 1.58 (1.07-2.33), respectively. In conclusion, rs763780 may play a critical role in the etiology of TB.

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“…16 The SNP IL-17A G-152A has been reported to be associated with several different infections and diseases such as childhood asthma, pulmonary tuberculosis and colorectal cancer. 16,22,23 However, data are scarce about the effect of the IL-17A G-152A polymorphism on IL-17A production or pneumococcal colonization and infections. Previously, Lu et al 12 reported that immunization of mice with S. pneumoniae confers CD4+ T cell-dependent protection against colonization.…”

Section: Discussionmentioning

confidence: 97%

The Gene Polymorphism of IL-17 G-152A is Associated with Increased Colonization of Streptococcus pneumoniae in Young Finnish Children

Vuononvirta

Peltola²,

Ilonen³

et al. 2015

Pediatric Infectious Disease Journal

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IL-17A and IL-17F genes variants and susceptibility to childhood asthma in Tunisia

Abstract: Our results suggested that SNPs in IL-17A and IL-17F confer susceptibility to childhood asthma in Tunisia.

Cited by 38 publications

References 37 publications

Genetic Variants of Interleukin 17A Are Functionally Associated with Increased Risk of Age-Related Macular Degeneration

Genetic Variants of Interleukin 17A Are Functionally Associated with Increased Risk of Age-Related Macular Degeneration

Influence of interleukin-17 gene polymorphisms on the development of pulmonary tuberculosis

The Gene Polymorphism of IL-17 G-152A is Associated with Increased Colonization of Streptococcus pneumoniae in Young Finnish Children

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