IL‐1β TNF‐α, and IL‐2 in Peritoneal Fluid and Macrophage‐Conditioned Media of Women With Endometriosis

Keenan, Jeffrey; Chen, Thomas T.; Chadwell, Nancy L.; Torry, Donald S.; Caudle, Michael R.

doi:10.1111/j.1600-0897.1995.tb00968.x

Cited by 159 publications

(77 citation statements)

References 19 publications

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“…Accumulating evidence supports the notion that the progression of endometriotic lesions is catalyzed by an aberrant immune response noted in the peritoneal cavity of women with endometriosis (23)(24)(25)(26)(27)(28)(29)(30). It is uncertain if the initial development of the disease is related to this inflammatory response.…”

Section: Discussionmentioning

confidence: 81%

PPAR-gamma receptor ligand induces regression of endometrial explants in baboons: A prospective, randomized, placebo- and drug-controlled study

Lebovic

Mwenda

Chai

et al. 2007

Fertility and Sterility

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Objective-To determine the effects of a thiazolidinedione (TZD) agonist of peroxisome proliferator-activated receptor (PPAR)-γ, rosiglitazone, in a baboon model of established endometriosis.Design-Prospective, randomized, placebo-controlled study.Setting-Experimental surgery laboratory at the Institute of Primate Research in Nairobi, Kenya.Animal(s)-Endometriosis was induced using intrapelvic injection of eutopic menstrual endometrium in 12 female baboons with a normal pelvis that had undergone at least one menstrual cycle since the time of captivity.Intervention(s)-Induction of endometriosis by laparoscopy was performed in 12 baboons with a normal pelvis. Endometrial tissue was extracted from each baboon by curettage and a standard amount of endometrium was then seeded onto several peritoneal sites as previously described. About 34-68 days after the induction of laparoscopy, a pre-treatment laparoscopy (baseline disease assessment) was performed in the baboons to record the extent of endometriotic lesions. The 12 baboons were randomized into 3 groups and treated from the day after the staging laparoscopy for a total duration of 30 days. They received either PBS tablets (n=4, placebo control; placebo tablets once a day by mouth for 30 days), GnRH-antagonists (n=4, active control; Ganirelix acetate 125 μg/day for 30 days) or rosiglitazone (n=4, test drug, 2 mg by mouth each day for 30 days). A 3 rd and final laparoscopy on day 30 after the start of treatment was performed to record the extent of endometriosis. The type of lesion (typical, red, white and suspicious) was recorded. Biopsies were obtained to confirm the histological presence of endometriosis.Main Outcome Measure(s)-A videolaparoscopy was performed 30 days after treatment to document the number and surface area of endometriotic lesions as well as to calculate the revised American Society for Reproductive Medicine score (rAFS) and stage.Corresponding author Dan I. Lebovic, M.D., M.A., Department of Obstetrics and Gynecology, University of Michigan, Tel: 734-615-8257, Fax: 734-647-1006, E-mail: lebovic@umich.edu Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. NIH Public Access

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Section: Discussionmentioning

confidence: 81%

PPAR-gamma receptor ligand induces regression of endometrial explants in baboons: A prospective, randomized, placebo- and drug-controlled study

Lebovic

Mwenda

Chai

et al. 2007

Fertility and Sterility

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“…Activated PMs can release a variety of cytokines, such as interleukin (IL)-1β and IL-6, into the peritoneal fluid and serum. These cytokines are involved in the pathophysiology of endometriosis [5][6][7].…”

Section: ------------------------------------------------------------mentioning

confidence: 99%

<i>Jing Tong Yu Shu</i>, a traditional Chinese medicine, suppresses IL-1β and IL-6 gene expressions in macrophages, and alleviates endometriosis

Tianchan¹,

Cong²,

Zhao³

et al. 2018

Trop. J. Pharm Res

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“…Peritoneal fluid from patients with endometriosis has frequently been shown to be toxic to the preimplantation embryo. A study demonstrated that medical treatment of endometriosis eliminated the embryotoxicity of the peritoneal fluid (Keenan et al,1995). In this study, the levels of IL-1 and TNF-were markedly reduced in the peritoneal fluid of women who had undergone medical treatment (danazol or intranasal buserelin for 4 to 6 months) of endometriosis.…”

Section: Cytokines and Endometriosis Related To Infertilitymentioning

confidence: 66%

Endometriosis and Angiogenic Factors

Artini¹,

Ruggiero²,

Papini³

et al. 2012

Endometriosis - Basic Concepts and Current Research Trends

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IL‐1β TNF‐α, and IL‐2 in Peritoneal Fluid and Macrophage‐Conditioned Media of Women With Endometriosis

Cited by 159 publications

References 19 publications

PPAR-gamma receptor ligand induces regression of endometrial explants in baboons: A prospective, randomized, placebo- and drug-controlled study

PPAR-gamma receptor ligand induces regression of endometrial explants in baboons: A prospective, randomized, placebo- and drug-controlled study

<i>Jing Tong Yu Shu</i>, a traditional Chinese medicine, suppresses IL-1β and IL-6 gene expressions in macrophages, and alleviates endometriosis

Endometriosis and Angiogenic Factors

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