1999
DOI: 10.1002/(sici)1521-4141(199907)29:07<2130::aid-immu2130>3.0.co;2-s
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IL-9 induces chemokine expression in lung epithelial cells and baseline airway eosinophilia in transgenic mice

Abstract: Recent data have identified IL-9 as a key cytokine in determining susceptibility to asthma. These data are supported by the finding that allergen-exposed IL-9-transgenic mice exhibit many features that are characteristic of human asthma (airway eosinophilia, elevated serum IgE and bronchial hyperresponsiveness) as compared to the background strain. A striking feature of these animals is a robust peribronchial and perivascular eosinophilia after allergen challenge, suggesting that IL-9 is a potent factor in reg… Show more

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Cited by 120 publications
(65 citation statements)
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“…In this context it has been shown that IL-9 induces the expression of the IL-5R ␣-chain on eosinophils (54) and that IL-13 induces eotaxin expression by several cell types, including airway epithelial cells (55)(56)(57)(58). Furthermore, it has been demonstrated that IL-9 induces the expression of CC chemokines, also acting as eosinophil chemotactic factors, by epithelial cells (59). We propose that LPS could be a powerful coactivating stimulus for mast cells in the course of inflammatory reactions and infectious diseases caused by Gram-negative bacteria, often following viral infections.…”
Section: Discussionmentioning
confidence: 85%
“…In this context it has been shown that IL-9 induces the expression of the IL-5R ␣-chain on eosinophils (54) and that IL-13 induces eotaxin expression by several cell types, including airway epithelial cells (55)(56)(57)(58). Furthermore, it has been demonstrated that IL-9 induces the expression of CC chemokines, also acting as eosinophil chemotactic factors, by epithelial cells (59). We propose that LPS could be a powerful coactivating stimulus for mast cells in the course of inflammatory reactions and infectious diseases caused by Gram-negative bacteria, often following viral infections.…”
Section: Discussionmentioning
confidence: 85%
“…It has been shown that IL-9 induces various chemotactic factors in mouse and human lung epithelial cells (4,26). Thus, we explored the effects of IL-9 on the chemokine production by astrocytes.…”
Section: Il-9 Induces Ccl-20 Production By Astrocytesmentioning
confidence: 99%
“…In addition, IL-9 protects T-cell lymphomas from dexamethasoneinduced apoptosis [5]. The involvement of IL-9 in asthma has been suggested by genetic studies [6][7][8] and is supported by its effects on IgE production [9], mucus production [10], mast cell differentiation [11], eosinophil activation [12] and bronchial hyper-responsiveness [13,14]. Finally, IL-9 is required for an efficient immune response against intestinal parasites such as Trichuris muris [15].…”
Section: Introductionmentioning
confidence: 99%