Images of psychopathology

Frith, C. D.; Dolan, Raymond J.

doi:10.1016/s0959-4388(98)80149-9

Cited by 31 publications

(15 citation statements)

References 32 publications

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“…In an Ôalien handÕ task, Franck et al (2001) showed that patients with passivity symptoms suffered from difficulties in correctly attributing the movement that they saw and replied randomly when they were given a weakly biased visual feedback (until 300 ms of delay and 30°of angular deviation). Similarly, verbal hallucinations can be interpreted as resulting from the misattribution of the inner speech (Frith & Done, 1989;Frith & Dolan, 1998;McGuire et al, 1996;Silbersweig et al, 1995).…”

Section: Discussionmentioning

confidence: 99%

Mental rotation in schizophrenia

Vignemont

Zalla

Posada

et al. 2006

Consciousness and Cognition

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Section: Discussionmentioning

confidence: 99%

Mental rotation in schizophrenia

Vignemont

Zalla

Posada

et al. 2006

Consciousness and Cognition

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“…In contrast to earlier work, in which the activity of typical or average brains (Posner & Raichle, 1995) or differences between normal and pathological brains (Frith & Dolan, 1998) were mapped, in recent studies correlations have been made between differences in brain activity during cognitive or affective processing and normal individual variation in characteristics such as intelligence (Gray, Chabris, & Braver, 2003), anxiety (Bishop, Duncan, Brett, & Lawrence, 2004;Etkin et al, 2004), extraversion, and neuroticism (Canli, Silvers, Whitfield, Gotlib, & Gabrieli, 2002;Canli et al, 2001).…”

mentioning

confidence: 90%

COMT genotype influences prefrontal response to emotional distraction

Bishop

Cohen

Fossella

et al. 2006

Cognitive, Affective, & Behavioral Neuroscience

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Early studies of genetic effects on brain activity have been conducted to investigate primarily either the influence of polymorphisms in dopaminergic genes, especially the catechol-O-methyltransferase (COMT) gene, on prefrontal cognitive processes such as working memory, or that of polymorphisms in the serotonin transporter gene on the amygdala response to threatening stimuli. Here, we address genetic influences on the neural systems underlying cognitive-affective interactions. Specifically, we assess the effect of the COMT val 158 met polymorphism on frontal regulation of attention under emotional distraction. Healthy volunteers were scanned while performing a house-matching task with affectively negative versus neutral distractors. Effects of val allele load were examined on frontal regions associated with attentional control and emotion regulation, and on parahippocampal regions associated with perception of houses. As we predicted, val load correlated positively with activity in control-and task-related regions during performance under emotional distraction. These findings provide an initial step toward identifying genetic contributions to interindividual variability in recruitment of mechanisms that regulate affective processing.

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“…In mammals, the importance of DA for motor control, cognitive abilities, and reward systems has been well documented (for reviews see Grace et al, 1998; Spangel and Weiss, 1999). Perturbations in DA action have been linked to Parkinson's disease, schizophrenia, and mood disorders (for reviews, see Birtwistle and Baldwin, 1998; Frith and Dolan, 1998; Willis and Armstrong, 1998). DA also appears to play a role in the higher integrative functions of invertebrates (Macmillan and Mercer, 1987; Neckameyer, 1998; Kokay et al, 1999).…”

mentioning

confidence: 99%

Dopamine-synthesizing neurons include the putative H-cell homologue in the mothManduca sexta

et al. 2001

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The catecholamine dopamine (DA) plays a fundamental role in the regulation of behavior and neurodevelopment across animal species. Uncovering the embryonic origins of neurons that express DA opens a path for a deeper understanding of how DA expression is regulated and, in turn, how DA regulates the activities of the nervous system. In a well-established insect model, Manduca sexta, we identified the putative homologue of the embryonic grasshopper "H-cell" using intracellular techniques, laser scanning confocal microscopy, and immunohistochemistry. In both species, this neuron possesses four axons and has central projections resembling the letter H. The H-cell in grasshoppers is known to be derived from the midline precursor 3 cell (MP3) and to pioneer the pathways of the longitudinal connectives; in Drosophila, the H-cell is also known to be derived from MP3. In the current study, we demonstrate that the Manduca H-cell is immunoreactive to antibodies raised against DA and its rate-limiting synthetic enzyme, tyrosine hydroxylase (TH). In larvae and adults, one DA/TH-immunoreactive (-ir) H-cell per ganglion is present. In embryos, individual ganglia contain a single midline TH-ir cell body positioned along side its putative sibling. Such observations are consistent with the known secondary transformation (in grasshoppers) of only one of the two MP3 progeny during early development. Although a hallmark feature of invertebrate neurons is the fairly stereotypical position of neuronal somata, we found that the H-cell somata can "flip-flop" by 180 degrees between an anterior and posterior position. This variability appears to be random and is not restricted to any particular ganglion. Curiously, what is segment-specific is the absence of the DA/TH-ir H-cell in the metathoracic (T3) ganglion as well as the unique structure of the H-cell in the subesophageal ganglion. Because this is the first immunohistochemical study of DA neurons in Manduca, we have provided the distribution pattern and morphologies of dopaminergic neurons, in addition to the H-cells, within the ventral nerve cord during development.

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Images of psychopathology

Cited by 31 publications

References 32 publications

Mental rotation in schizophrenia

Mental rotation in schizophrenia

COMT genotype influences prefrontal response to emotional distraction

Dopamine-synthesizing neurons include the putative H-cell homologue in the mothManduca sexta

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