Imaging Brain DHA Metabolism in Vivo, in Animals, and Humans

Rapoport, Stanley I.; Taha, Ameer Y.

doi:10.1016/b978-0-12-410527-0.00022-3

Cited by 3 publications

(1 citation statement)

References 79 publications

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“…Furthermore, sPLA 2 -catalyzed degradation of phospholipids with sn -2 polyunsaturated alkyl chains generates polyunsaturated fatty acids, which are crucial in many physiological processes and in modulation and prevention of diseases. , For example, docosahexaenoic acid helps the brain to maintain its structures and functions, and arachidonic acid (AA) is involved in cell signaling and important in defending against inflammatory diseases. − However, molecular interactions of polyunsaturated lipids with sPLA 2 have rarely been systematically investigated. Therefore, the need to understand its role in related physiological and pathological processes gives impetus to the quantitative investigation of the degradation of polyunsaturated phospholipids catalyzed by sPLA 2 .…”

Section: Introductionmentioning

confidence: 99%

Polyunsaturated Phospholipid Modified Membrane Degradation Catalyzed by a Secreted Phospholipase A2

Zhang¹,

Villanueva²,

Kalkowski³

et al. 2019

Langmuir

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To optimize the compositions of the lipid-based nanomedicine and to advance understanding of the roles of polyunsaturated phospholipids in biological membranes, this study examined the effects of polyunsaturated phospholipids on the degradation of giant unilamellar vesicles catalyzed by a secreted phospholipase A2 (sPLA 2 ) using fluorescence microscopy. Molecular interfacial packing, interaction, and degradation of the films containing various mixing ratios of saturated and polyunsaturated phospholipids were quantified using a Langmuir trough integrated with synchrotron X-ray surface scattering techniques. It was found that a high molar fraction (0.63 and above) of polyunsaturated phospholipids not only enhanced the rate of sPLA 2 -catalyzed vesicle degradation but also changed the vesicle deformation process and degradation product morphology. Hydrolysis of the saturated phospholipids generated highly ordered liquid crystal domains, which was reduced or prohibited by the presence of the polyunsaturated phospholipids in the reactant film.

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Section: Introductionmentioning

confidence: 99%

Polyunsaturated Phospholipid Modified Membrane Degradation Catalyzed by a Secreted Phospholipase A2

Zhang¹,

Villanueva²,

Kalkowski³

et al. 2019

Langmuir

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Linoleic acid-derived 13-hydroxyoctadecadienoic acid is absorbed and incorporated into rat tissues

Zhang

Emami

Hennebelle

et al. 2021

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biolog

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Marine omega‐3 (n‐3) phospholipids: A comprehensive review of their properties, sources, bioavailability, and relation to brain health

Ahmmed

Tian³

et al. 2019

Comp Rev Food Sci Food Safe

158

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For several decades, there has been considerable interest in marine‐derived long chain n‐3 fatty acids (n‐3 LCPUFAs) due to their outstanding health benefits. n‐3 LCPUFAs can be found in nature either in triglycerides (TAGs) or in phospholipid (PL) form. From brain health point of view, PL n‐3 is more bioavailable and potent compared to n‐3 in TAG form, as only PL n‐3 is able to cross the blood–brain barrier and can be involved in brain biochemical reactions. However, PL n‐3 has been ignored in the fish oil industry and frequently removed as an impurity during degumming processes. As a result, PL products derived from marine sources are very limited compared to TAG products. Commercially, PLs are being used in pharmaceutical industries as drug carriers, in food manufacturing as emulsifiers and in cosmetic industries as skin care agents, but most of the PLs used in these applications are produced from vegetable sources that contain less (without EPA, DPA, and DHA) or sometimes no n‐3 LCPUFAs. This review provides a comprehensive account of the properties, structures, and major sources of marine PLs, and provides focussed discussion of their relationship to brain health. Epidemiological, laboratory, and clinical studies on n‐3 LCPUFAs enriched PLs using different model systems in relation to brain and mental health that have been published over the past few years are discussed in detail.

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Imaging Brain DHA Metabolism in Vivo, in Animals, and Humans

Cited by 3 publications

References 79 publications

Polyunsaturated Phospholipid Modified Membrane Degradation Catalyzed by a Secreted Phospholipase A2

Polyunsaturated Phospholipid Modified Membrane Degradation Catalyzed by a Secreted Phospholipase A2

Linoleic acid-derived 13-hydroxyoctadecadienoic acid is absorbed and incorporated into rat tissues

Marine omega‐3 (n‐3) phospholipids: A comprehensive review of their properties, sources, bioavailability, and relation to brain health

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