Immediate hypersensitivity to <i>Malassezia furfur</i> in patients with atopic dermatitis

Khosravi, Alireza; Hedayati, Mohammad Taghi; Mansouri, Parvin; Shokri, Hojjatollah; Moazzeni, Seyed Mohammad

doi:10.1111/j.1439-0507.2007.01365.x

Cited by 9 publications

(4 citation statements)

References 32 publications

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“…In a study conducted by Khosravi et al. [32] 41.4% of AE patients, who had other allergic disorders, showed positive reactions to Malassezia furfur antigens. In this study, 38.9% of AE patients had also other allergic disorders.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Candida albicans allergens reactive with specific IgE in asthma and atopic eczema patients

Khosravi¹,

Bandghorai²,

Moazzeni³

et al. 2009

Mycoses

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Candida albicans (C. albicans) produces important allergenic components which can induce allergic reactions in sensitised patients. The purpose of this study was to extract the C. albicans antigens for evaluating the specific anti-Candida IgE in sera of atopic eczema (AE) and asthmatic patients (AS). 95 AE, 85 AS, and 70 non-atopic cases were selected with sequential trials. Candida albicans antigens were prepared and then skin prick test (SPT), ELISA and IgE-immunoblotting tests were performed for all patients. Positive SPT reactions were obtained on 52.6% of AE and 54.1% of AS patients and 4.3% of healthy controls (P < 0.05). Using ELISA, specific anti-C. albicans IgE antibody was detected in 32.6% and 41.2% of patients with AE and AS, respectively. No specific IgE antibody was detected in healthy controls (P < 0.05). In SDS-PAGE, protein bands with molecular weights between 13 and 135 kDa were detected, and some of them reacted with specific IgE in immunoblotting. In AE patients, the most important allergenic components were 25, 34, and 57 kDa protein bands, whereas in AS, 22, 25, and 34 kDa protein bands were observed as major allergens. Candida albicans produces different allergenic components that can induce allergic reactions and may be pathogenetically important in patients with AE and AS.

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Section: Discussionmentioning

confidence: 99%

Evaluation of Candida albicans allergens reactive with specific IgE in asthma and atopic eczema patients

Khosravi¹,

Bandghorai²,

Moazzeni³

et al. 2009

Mycoses

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“…Patients present with itching, which could be the body's reaction to irritants or microorganisms, brought about by loss of surface barrier mechanisms and dry skin [ Figure 1 ]. [ 3 41 42 ]…”

Section: Clinical Scenariomentioning

confidence: 99%

“…More studies are needed to understand the role of Malassezia and its mechanisms of disease, chronicity and exacerbations. [ 3 15 41 42 43 44 45 46 47 48 49 50 51 52 ]…”

Section: Clinical Scenariomentioning

confidence: 99%

Malassezia-Can it be ignored?

2015

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Genus Malassezia comprises of 14 species of “yeast like fungi,” 13 of which are lipophilic and 1 is nonlipophilic. They are known commensals and in predisposed individuals they commonly cause a spectrum of chronic recurrent infections. They rarely also cause serious illnesses like catheter-related blood stream infections, CAPD associated peritonitis etc., Though these fungi have been known to man for over 150 years, their fastidious nature and cumbersome culture and speciation techniques have restricted research. Since the last taxonomic revision, seven new species have been added to this genus. Their ability to evade the host immune system and virulence has increased the spectrum of the diseases caused by them. These agents have been implicated as causal agents in common diseases like atopic dermatitis recently. Though culture-based research is difficult, the new molecular analysis techniques and facilities have increased research in this field such that we can devote more attention to this genus to study in detail, their characteristics and their growing implications implications in the clinical scenario.

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“…Сложнее обстоит дело в случаях распространенных и атипичных форм разноцветного лишая, так как в этих случаях могут допускаться диагнос тические ошибки [8,13]. Дело в том, что M.furfur в настоящее время рассматривается как один из этиологических факторов таких дерматозов, как себорейный дерматит [12,14,15] и атопический дерматит [16,17,18,19], при чем активно влияет на клиническое течение указанных дерматозов.…”

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Lysozyme activity determination using peptidoglycan from the cell wall of Micrococcus lysodeikticus

Goncharova¹,

Ziamko²,

Окулич³

2018

Immunopathol Allergol Infecto

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Проведены исследования показателей эндогенной инток сикации (ССЭ и СМП) у 120 больных с распространенны ми и атипичными формами разноцветного лишая, позво лившие включить в комплексное лечение данного мико за препарат Глутоксим, который проявил себя как деток сицирующий препарат. Разработанный метод терапии позволил повысить процент клинического и микологи ческого излечения с 78,3% до 96,7% случаев. Определе ние показателей эндогенной интоксикации можно реко мендовать для прогнозирования течения и мониторинга эффективности комплексного лечения больных разно цветным лишаем.

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Immediate hypersensitivity to Malassezia furfur in patients with atopic dermatitis

Cited by 9 publications

References 32 publications

Evaluation of Candida albicans allergens reactive with specific IgE in asthma and atopic eczema patients

Evaluation of Candida albicans allergens reactive with specific IgE in asthma and atopic eczema patients

Malassezia-Can it be ignored?

Lysozyme activity determination using peptidoglycan from the cell wall of Micrococcus lysodeikticus

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