Immediate versus late effects of vigabatrin on spike and wave discharges

Perescis, M.F.J.; Luijtelaar, Gilles van; Rijn, Clementina M. van

doi:10.1016/j.eplepsyres.2020.106379

Cited by 9 publications

(7 citation statements)

References 49 publications

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“…The reticular thalamic nucleus (RT) ‘s leading role in the GABA-ergic suppression of specific thalamic nuclei was strengthened last time [28]. Such data were in line with the two-phase effects of vigabatrin upon SWD [29] and with the suppression of SWD caused by DBS of RT [30].…”

Section: Introductionmentioning

confidence: 73%

“…Intensively developed investigations of genetic forms of absence seizures performed during the last decades [10][11][12][13][14]. Calcium channel deteriorations may underlay such hyperactive state of neurons within the CTC networks due to an with the two-phase effects of vigabatrin upon SWD [29] and with the suppression of SWD caused by DBS of RT [30].…”

Section: Introductionmentioning

confidence: 99%

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Cerebellar Contribution to Absence Epilepsy

Godlevsky

Pinyazhko

Poshyvak

2020

Preprint

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The new aggregate data analyses revealed the earlier missing role played by the cerebellum long-term electrical stimulation in the absence epilepsy. Neurophysiologic data gained by authors favor that cerebellar serial deep brain stimulation (DBS) (100 Hz) causes the transformation of penicillin-induced cortical focal discharges into prolonged 3,5-3,75 sec oscillations resembling spike-wave discharges (SWD) in cats. Such SWDs were not organized in the form of bursts and persisted continuously after stimulation. Therefore the appearance of prolonged periods of SWD is regarded as a tonic cerebellar influence upon pacemaker of SWD and might be caused by the long-lasting DBS-induced increase of GABA-ergic extrasynaptic inhibition in forebrain networks. At the same time, cerebellar DBS high-frequency (100 Hz) suppressed bursts of SWD observed during the phase of stimulation. Different types of cerebellar DBS upon epileptic activity emphasized the absence seizure facilitation discussed with the reviewed data on optogenetic stimulation, neuronal activity of cerebellar structures, and functional magnetic resonance imaging data.

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Section: Introductionmentioning

confidence: 73%

Section: Introductionmentioning

confidence: 99%

Cerebellar Contribution to Absence Epilepsy

Godlevsky

Pinyazhko

Poshyvak

2020

Preprint

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“…It seems like early-life caffeine exposure has influence on mechanisms of seizure generation rather than seizure termination. It should be emphasized that SWD occurrence is triggered in the somatosensory cortex while reticular thalamic nucleus is known to be associated with SWD termination [51].…”

Section: Discussionmentioning

confidence: 99%

Effects of Postnatal Caffeine Exposure on Absence Epilepsy and Comorbid Depression: Results of a Study in WAG/Rij Rats

et al. 2022

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The present study aims to investigate effect of early caffeine exposure on epileptogenesis and occurrence of absence seizures and comorbid depression in adulthood. For this purpose, Wistar Albino Glaxo from Rijswijk (WAG/Rij) rats were enrolled in a control and two experimental groups on the 7th day after the delivery. The rats in experimental groups received either 10 or 20 mg/kg caffeine subcutaneously while animals in control group had subcutaneous injections of 0.9% saline. The injections started at postnatal day 7 (PND7) and were continued each day for 5 days. At 6–7 months of age, electroencephalogram (EEG) recordings and behavioral recordings in the forced swimming test, sucrose consumption/preference test and locomotor activity test were carried out. At 6 months of age, 10 mg/kg and 20 mg/kg caffeine-treated WAG/Rij rats showed increased immobility latency and active swimming duration in forced swimming test when compared with the untreated controls. In addition, 20 mg/kg caffeine treatment decreased immobility time. In sucrose preference/consumption tests, WAG/Rij rats in 10 mg/kg caffeine group demonstrated higher sucrose consumption and preference compared to untreated controls. The rats treated with 20 mg/kg caffeine showed higher sucrose preference compared to control rats. The exploratory activity of rats in the 10 mg/kg caffeine-treated group was found to be higher than in the 20 mg/kg caffeine-treated and control groups in the locomotor activity test. At 7 months of age, caffeine-treated animals showed a decreased spike-wave discharge (SWD) number compared to the control animals. These results indicate that postnatal caffeine treatment may decrease the number of seizure and depression-like behaviors in WAG/Rij rats in later life. Caffeine blockade of adenosine receptors during the early developmental period may have beneficial effects in reducing seizure frequency and depression-like behaviors in WAG/Rij rat model.

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“…Spike–wave discharges (SWDs) in the Wistar rats were identified by high‐amplitude spike–wave oscillation ranging from 5 to11 Hz (Akman et al, 2010; André et al, 2014; Coenen & van Lujitelaar, 2003; Fan et al, 2016; Ferreira et al, 2003; Klein et al, 2004; Navidhamidi et al, 2017; Perescis et al, 2020; Pinault et al, 2006; Shaw, 2007; Taylor et al, 2019) recorded during the awake state associated to behaviour arrest to distinguish from the sleep‐related spindle (7–15 Hz) oscillations (Pinault et al, 2006). The entire video‐EEG recordings of each animal were analysed to identify the occurrence of SWD.…”

Section: Methodsmentioning

confidence: 99%

“…We reported that the VPA animal model presents face validity regarding electrophysiological issues, reproducing behaviour and EEG abnormalities from ASD animal models, characterized by altered brain oscillations and SWD events at around 6-7 Hz (Akman et al, 2010;Perescis et al, 2020;Pinault et al, 2006) associated with behaviour arrest on EEG in 40% of cases. This finding is similar to other animal models of absence seizures, such as the WAG/Rij rats (Kleijer et al, 2018;Perescis et al, 2020;Santos et al, 2018). On the other hand, SWD with behaviour arrest, called SWD/immobility, was also found in outbred laboratory rats but with lower incidence and shorter burst duration (average of 1.25 s; Taylor et al, 2019).…”

mentioning

confidence: 99%

GABAergic synaptic transmission and cortical oscillation patterns in the primary somatosensory area of a valproic acid rat model of autism spectrum disorder

Fontes-Dutra

Marafiga

Santos-Terra

et al. 2022

Eur J of Neuroscience

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Autism spectrum disorder (ASD) is characterized by impaired social communication and interaction associated with repetitive or stereotyped behaviour. Prenatal valproic acid (VPA) exposure in rodents is a commonly used model of ASD. Resveratrol (RSV) has been shown to prevent interneuronal and behavioural impairments in the VPA model. We investigated the effects of prenatal VPA exposure and RSV on the GABAergic synaptic transmission, brain oscillations and on the genic expression of interneuron‐associated transcription factor LHX6 in the primary somatosensory area (PSSA). Prenatal VPA exposure decreased the sIPSC and mIPSC frequencies and the sIPSC decay kinetics onto layers 4/5 pyramidal cells of PSSA. About 40% of VPA animals exhibited absence‐like spike–wave discharge (SWD) events associated with behaviour arrest and increased power spectrum density of delta, beta and gamma cortical oscillations. VPA animals had reduced LHX6 expression in PSSA, but VPA animals treated with RSV had no changes on synaptic inhibition or LHX6 expression in the PSSA. SWD events associated with behaviour arrest and the abnormal increment of cortical oscillations were also absent in VPA animals treated with RSV. These findings provide new venues to investigate the role of both RSV and VPA in the pathophysiology of ASD and highlight the VPA animal model as an interesting tool to investigate pathways related to the aetiology and possible future therapies to this neuropsychiatric disorder.

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Immediate versus late effects of vigabatrin on spike and wave discharges

Cited by 9 publications

References 49 publications

Cerebellar Contribution to Absence Epilepsy

Cerebellar Contribution to Absence Epilepsy

Effects of Postnatal Caffeine Exposure on Absence Epilepsy and Comorbid Depression: Results of a Study in WAG/Rij Rats

GABAergic synaptic transmission and cortical oscillation patterns in the primary somatosensory area of a valproic acid rat model of autism spectrum disorder

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