Immobilization Stress Inhibits Intimal Fibromuscular Proliferation in the Process of Arterial Remodeling in Rats

Iwai, Kunimitsu; Takahashi, Takashi; Nakahashi, Takeshi; Nomura, Koji; Atsumi, Mikiko; Zeng, Li; Ishigami, Keiichiro; Kanda, Tsugiyasu; Yamaguchi, Nobuo; Morimoto, Shigeto

doi:10.1291/hypres.31.977

Cited by 5 publications

(1 citation statement)

References 54 publications

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“…In our study, serum β-endorphin level was significantly increased in the immobilization-stress group. The result was like that of previous studies [ 51 , 52 , 53 ]. However, pretreatment with MA and FMA extract gradually reduced the concentration of β-endorphin as compared to the stress group.…”

Section: Discussionsupporting

confidence: 91%

The Anti-Stress Effect of Mentha arvensis in Immobilized Rats

Tian

Akanda

Islam

et al. 2018

IJMS

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Stress can lead to inflammation, accelerated aging, and some chronic diseases condition. Mentha arvensis (MA) is a traditional medicine having antioxidant and anti-inflammatory activities. The present study investigated the anti-stress role of MA and fermented MA (FMA) extract in immobilized rats. We studied the lipopolysaccharide (LPS)-induced inflammation in RAW 264.7 cells and rats were immobilized for 2 h per day for 14 days using a restraining cage. MA (100 mg/kg) and FMA (100 mg/kg) were orally administered to rats 1 h prior to immobilization. Using high-performance liquid chromatography (HPLC) analysis, we determined the rosmarinic acid content of MA and FMA. The generation of malondialdehyde (MDA) and nitric oxide (NO) in RAW 246.7 cells were suppressed by both MA and FMA. In rats, MA and FMA notably improved the body weight, daily food intake, and duodenum histology. MDA and NO level were gradually decreased by MA and FMA treatment. MA and FMA significantly controlled the stress-related hormones by decreasing corticosterone and β-endorphin and increasing serotonin level. Moreover, protein expression levels of mitogen activated protein kinases (MAPK) and cyclooxygenase-2 (COX-2) were markedly downregulated by MA and FMA. Taken together, MA and FMA could ameliorate immobilized-stress by reducing oxidative stress, regulating stress-related hormones, and MAPK/COX-2 signaling pathways in rats. Particularly, FMA has shown greater anti-stress activities than MA.

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Section: Discussionsupporting

confidence: 91%

The Anti-Stress Effect of Mentha arvensis in Immobilized Rats

Tian

Akanda

Islam

et al. 2018

IJMS

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Effect of Opiate Receptors Blockade on Microbicidal Potential and Production of IL-1β, TNFα, and IL-10 by Peritoneal Macrophages under Stress Conditions

Гейн

Sharavieva

2016

Bull Exp Biol Med

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Rotation stress activated spontaneous and zymosan-induced ROS production. In animals receiving naloxone against the background of rotation stress, ROS production did not increase. Immobilization stress did not change the intensity of spontaneous and zymosan-induced ROS production, but inhibited stimulated ROS production against the background of naloxone treatment. Rotation produced a naloxone-independent inhibitory effect on spontaneous and stimulated IL-1β and TNFα production by macrophages and naloxone-dependent stimulating effect on spontaneous IL-10 production. Rotation stress did not modulate stimulated IL-10 production. In case of immobilization stress, decreased IL-1β and TNFα production was observed in mice exposed to stress under conditions of opiate receptors blockade; IL-10 production was not affected by immobilization stress. Both types of stress significantly increased plasma corticosterone levels, while naloxone had no effect on corticosterone production.

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