Immobilized Ag NPs on chitosan-biguanidine coated magnetic nanoparticles for synthesis of propargylamines and treatment of human lung cancer

Ma, Dongyang; Han, Tong; Karimian, Mohammad; Abbasi, Naser; Ghaneialvar, Hori; Zangeneh, Akram

doi:10.1016/j.ijbiomac.2020.09.193

Cited by 49 publications

(15 citation statements)

References 38 publications

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“…Due to the importance of propargylamines, various metal complexes and salts have been used to achieve this reaction under homogeneous or heterogeneous conditions. [20,27,[62][63][64][65][66][67][68] In continuation of our previous research on the development of functionalized nanocatalysts and their applications in various organic transformations, [69][70][71] herein, we report a novel heterogeneous and recyclable triazine-based Cu-NNN-pincer complex, Fe 3 O 4 @SiO 2 -NH-CCl-AT-Cu(II), as a novel, nontoxic, and low-cost catalyst for the preparation of propargylamines from A 3 coupling reactions of aldehydes, phenylacetylene, and amines.…”

Section: Introductionmentioning

confidence: 89%

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Synthesis, characterization, and reactivity of a novel magnetically recyclable triazine‐based Cu–NNN–pincer complex

Ahmed

Amani

2022

Applied Organom Chemis

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A new heterogeneous catalytic system containing triazine-based copper(II) tridentate-NNN-pincer complex, covalently anchored to the aminefunctionalized silica-coated Fe 3 O 4 magnetic nanoparticles, Fe 3 O 4 @SiO 2 -NH-CCl-AT-Cu(II), was synthesized. Its structure was studied through the standard methods of FT-IR, NMR, EDX, TGA, FE-SEM, MAP images, XRD, ICP, and N 2 adsorption-desorption isotherm analysis and utilized for the production of propargylamines by one-pot A 3 coupling of phenylacetylene, aldehydes, and secondary amines, attaining TOF values of up to 40,000 h À1 . The impact of various solvents, reaction time, temperature, catalyst amount, and recyclability of the catalyst were studied to optimize reaction conditions. The catalyst was re-examined five times, and no noteworthy reduction in activity was observed. K E Y W O R D S2-amino-5-mercapto-1,3,4-thiadiazole (denoted as AT), A 3 coupling reaction, copper(II), propargylamine, triazine-based NNN-pincer ligand

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Section: Introductionmentioning

confidence: 89%

“…Due to the importance of propargylamines, various metal complexes and salts have been used to achieve this reaction under homogeneous or heterogeneous conditions. [ 20,27,62–68 ]…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization, and reactivity of a novel magnetically recyclable triazine‐based Cu–NNN–pincer complex

Ahmed

Amani

2022

Applied Organom Chemis

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“…Guanylguanidine-based catalyst Ag/Bigua-CS@Fe 3 O 4 (C41) for synthesis of propargylamines. [112] ChemistrySelect excellent yields (65-95 %). Moreover, the catalytic activity was retained even after eight cycles.…”

Section: A 3 Couplingmentioning

confidence: 98%

“…Recently, Ma et al [112] developed a new guanylguanidine based catalyst by immobilizing silver nanoparticles on guanylguanidine-functionalized chitosan coated magnetic nanoparticles. This catalyst, Ag/Bigua-CS@Fe 3 O 4 (C41, Figure 10iv) was evaluated for its catalytic activity for propargylamines synthesis.…”

Section: A 3 Couplingmentioning

confidence: 99%

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Guanylguanidines: Catalyst and Ligand for Organic Transformations

Bankar¹,

Kathuria

2022

ChemistrySelect

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Guanylguanidines are well known for their wide range of therapeutic applications such as antidiabetic, anticancer, antifilarial, antitrypanosomal, antiaging, etc. Apart from this, they have been explored in the field of crystal engineering, organic synthesis as substrate, non‐linear optics etc. Their metal complexation ability and superbasic nature has paved their way in the field of organocatalysis. In the recent past, various guanylguanidine derivatives have been synthesized and have proven to be excellent catalysts in several organic reactions which include transesterification, C−C and C−N coupling, oxidation, reduction, Beckmann rearrangement etc. However, the limited studies call for more focused research in this direction to fasten the process of development of environmental‐friendly methods. In this review, a comprehensive and systematic discussion of guanylguanidine based catalysts and their applications in various organotransformations has been compiled and discussed meticulously. This review aims to highlight guanylguanidine moiety as a potential catalyst that can be utilized for design and development of novel guanylguanidine based catalysts.

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Metal Nanoparticles as Novel Agents for Lung Cancer Diagnosis and Therapy

Zheng

Zuo

et al. 2023

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Lung cancer is one of the most common malignancies worldwide and contributes to most cancer‐related morbidity and mortality cases. During the past decades, the rapid development of nanotechnology has provided opportunities and challenges for lung cancer diagnosis and therapeutics. As one of the most extensively studied nanostructures, metal nanoparticles obtain higher satisfaction in biomedical applications associated with lung cancer. Metal nanoparticles have enhanced almost all major imaging strategies and proved great potential as sensor for detecting cancer‐specific biomarkers. Moreover, metal nanoparticles could also improve therapeutic efficiency via better drug delivery, improved radiotherapy, enhanced gene silencing, and facilitated photo‐driven treatment. Herein, the recently advanced metal nanoparticles applied in lung cancer therapy and diagnosis are summarized. Future perspective on the direction of metal‐based nanomedicine is also discussed. Stimulating more research interests to promote the development of metal nanoparticles in lung cancer is devoted.

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Immobilized Ag NPs on chitosan-biguanidine coated magnetic nanoparticles for synthesis of propargylamines and treatment of human lung cancer

Cited by 49 publications

References 38 publications

Synthesis, characterization, and reactivity of a novel magnetically recyclable triazine‐based Cu–NNN–pincer complex

Synthesis, characterization, and reactivity of a novel magnetically recyclable triazine‐based Cu–NNN–pincer complex

Guanylguanidines: Catalyst and Ligand for Organic Transformations

Metal Nanoparticles as Novel Agents for Lung Cancer Diagnosis and Therapy

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