Immune activation is associated with reduced skeletal muscle mass and physical function in chronic heart failure

Toth, Michael J.; Ades, Philip A.; Tischler, Marc D.; Tracy, Russell P.; LeWinter, Martin M.

doi:10.1016/j.ijcard.2005.06.006

Cited by 100 publications

(105 citation statements)

References 41 publications

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“…Studies have shown that CHF is associated with reduced skeletal muscle strength per unit muscle size (9,28). This contractile deficit at the whole muscle level has been observed in isolated muscle tissue in animal models (16,21) and in chemically skinned, single muscle fibers in humans (26), suggesting that the heart failure syndrome promotes contractile dysfunction at the level of the myofilaments.…”

Section: Discussionmentioning

confidence: 98%

“…Written, informed consent was obtained from each research subject. Data on these volunteers regarding the effect of heart failure on skeletal muscle protein expression and whole muscle function have been published previously (27,28).…”

Section: Methodsmentioning

confidence: 99%

“…Although cardiac pump dysfunction can limit exercise capacity, research conducted over the last two decades has highlighted the importance of changes in the skeletal musculature in heart failure (10,21,37). Recent studies have shown that skeletal muscle strength is reduced in heart failure and that this decrement cannot be solely accounted for by a reduction in muscle mass (9,28), suggesting a fundamental defect in skeletal muscle contractile function. Recent studies have confirmed this at the cellular level.…”

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confidence: 99%

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Skeletal muscle contractile protein function is preserved in human heart failure

Okada

Toth²,

VanBuren³

2008

Journal of Applied Physiology

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Section: Discussionmentioning

confidence: 98%

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

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Skeletal muscle contractile protein function is preserved in human heart failure

Okada

Toth²,

VanBuren³

2008

Journal of Applied Physiology

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“…This underlies the "skeletal muscle hypothesis" of exercise intolerance in CHF (Clark et al, 1996). However, most studies addressing the "skeletal muscle hypothesis" in humans have focused primarily on isolated skeletal muscle, including histology, biochemistry (Sullivan et al, 1990), morphology Panizzolo et al, 2014) and strength (Lipkin et al, 1988;Toth et al, 2006). It is likely that these factors all contribute to some extent to reduced functional walking performance in CHF.…”

Section: Introductionmentioning

confidence: 99%

Gait analysis in chronic heart failure: The calf as a locus of impaired walking capacity

Panizzolo

Maiorana

Naylor

et al. 2014

Journal of Biomechanics

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a b s t r a c tReduced walking capacity, a hallmark of chronic heart failure (CHF), is strongly correlated with hospitalization and morbidity. The aim of this work was to perform a detailed biomechanical gait analysis to better identify mechanisms underlying reduced walking capacity in CHF. Inverse dynamic analyses were conducted in CHF patients and age-and exercise level-matched control subjects on an instrumented treadmill at self-selected treadmill walking speeds and at speeds representing þ 20% and -20% of the subjects' preferred speed. Surprisingly, no difference in preferred speed was observed between groups, possibly explained by an optimization of the mechanical cost of transport in both groups (the mechanical cost to travel a given distance; J/kg/m). The majority of limb kinematics and kinetics were also similar between groups, with the exception of greater ankle dorsiflexion angles during stance in CHF. Nevertheless, over two times greater ankle plantarflexion work during stance and per distance traveled is required for a given triceps surae muscle volume in CHF patients. This, together with a greater reliance on the ankle compared to the hip to power walking in CHF patients, especially at faster speeds, may contribute to the earlier onset of fatigue in CHF patients. This observation also helps explain the high correlation between triceps surae muscle volume and exercise capacity that has previously been reported in CHF. Considering the key role played by the plantarflexors in powering walking and their association with exercise capacity, our findings strongly suggest that exercise-based rehabilitation in CHF should not omit the ankle muscle group.

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“…In addition to contributing to the pathophysiology and the progression of structural and functional changes in the heart muscle, these inflammatory mediators may directly lead to peripheral manifestations of the HF syndrome, especially in those changes related to a decrease in muscle mass and functional changes 10,11 , among others.…”

Section: Introductionmentioning

confidence: 99%

Efeito anti-inflamatório do treinamento físico na insuficiência cardíaca: papel do TNF-α e da IL-10

Júnior¹,

Lópes²,

Seelaender³

et al. 2009

Arq. Bras. Cardiol.

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Over the past 50 years, the understanding of the deteriorative changes involved in the progression of heart failure (HF), initially described as resulting from changes in salt and fluid retention, or changes in hemodynamic parameters, have changed significantly. Recently, several studies conducted in HF patients showed altered plasma (or serum) levels of pro-inflammatory cytokines, such as tumor necrosis factor α (TNF-α), interleukins 1, 6, and 18, and cardiotropin-1, among other inflammatory markers. These changes were independent of HF etiology, suggesting a common pathogenic pathway. In response to these new findings, interventions to prevent and/or reduce these inflammatory changes have been proposed.The aerobic training-induced cardiovascular benefits of physical exercises performed at intensities ranging from mild to moderate have been previously reported. Moreover, it has been shown that moderate aerobic physical training seems to be able to modulate, in the presence of an abnormal chronic inflammatory condition, the overexpression of pro-inflammatory cytokines, soluble adhesion molecules, chemoattractant factors and oxidative stress. Altogether, these data indicate a possible anti-inflammatory effect induced by physical training.Therefore, this review aims to assess the role of physical training as an alternative non-pharmacological adjuvant to be administered in some pathological conditions in which TNF-α chronic changes are predominant, as in HF. The "antiinflammatory effect" induced by physical training seems to be primarily mediated by IL-10.

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Immune activation is associated with reduced skeletal muscle mass and physical function in chronic heart failure

Cited by 100 publications

References 41 publications

Skeletal muscle contractile protein function is preserved in human heart failure

Skeletal muscle contractile protein function is preserved in human heart failure

Gait analysis in chronic heart failure: The calf as a locus of impaired walking capacity

Efeito anti-inflamatório do treinamento físico na insuficiência cardíaca: papel do TNF-α e da IL-10

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