Immune Defense against S. Epidermidis Biofilms: Components of the Extracellular Polymeric Substance Activate Distinct Bactericidal Mechanisms of Phagocytic Cells

Meyle, Eva; Brenner‐Weiß, Gerald; Obst, Ursula; Prior, Birgit; Hänsch, Gertrud Maria

doi:10.5301/ijao.5000151

Cited by 34 publications

(27 citation statements)

References 29 publications

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“…Neutrophil presence at the site of infection was found to be dependent on IL-1β secretion and both components appeared to have a protective role in a post arthroplasty model (Meyle et al 2012, Bernthal et al 2011). Nonetheless, neutrophils are not capable of overcoming the infection even when present as their action can be hampered by bacterial production of poly-N-acetylglucosamine and poly-y-acid (PGA), which prevent bacterial engulfment by neutrophil and antibody mediated phagocytosis.…”

Section: Immune Response To Biofilmsmentioning

confidence: 95%

“…Different studies have reported that bacterial biofilms are able to recruit macrophages and neutrophils to the site of infection, albeit not to the extent of the planktonic form (Thurlow et al 2011, Meyle et al 2012, Cerca et al 2011, Snowden et al 2012, Snowden et al 2013). Macrophages responding to the infection display dysfunctional phagocytic activity by a still unknown mechanism (Thurlow et al 2011).…”

Section: Immune Response To Biofilmsmentioning

confidence: 98%

“…Neutrophils have also been found to be relevant for the containment of biofilm infections (Meyle et al 2012). Neutrophil presence at the site of infection was found to be dependent on IL-1β secretion and both components appeared to have a protective role in a post arthroplasty model (Meyle et al 2012, Bernthal et al 2011).…”

Section: Immune Response To Biofilmsmentioning

confidence: 99%

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Ventricular shunt infections: Immunopathogenesis and clinical management

Gutierrez-Murgas

Snowden

2014

Journal of Neuroimmunology

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Ventricular shunts are the most common neurosurgical procedure performed in the United States. This hydrocephalus treatment is often complicated by infection of the device with biofilm-forming bacteria. In this review, we discuss the pathogenesis of shunt infection, as well as the implications of the biofilm formation on treatment and prevention of these infections. Many questions remain, including the contribution of glia and the impact of inflammation on developmental outcomes following infection. Immune responses within the CNS must be carefully regulated to contain infection while minimizing bystander damage; further study is needed to design optimal treatment strategies for these patients.

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Section: Immune Response To Biofilmsmentioning

confidence: 95%

Section: Immune Response To Biofilmsmentioning

confidence: 98%

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Ventricular shunt infections: Immunopathogenesis and clinical management

Gutierrez-Murgas

Snowden

2014

Journal of Neuroimmunology

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“…Multiple studies have reported that human PMNs in in vitro co-culture with S. aureus localize to the biofilm and can phagocytose bacteria (279, 280). In an S. epidermidis biofilm grown in vitro , PMNs were able to attach to the biofilm, release granule components from both primary and secondary granules, and phagocytose biofilm bacteria (281). These effects were observed with or without opsonization, which suggest they are mediated at least in part by bacterial components that interact with the PMNs.…”

Section: Evasion Of the Host Immune Systemmentioning

confidence: 99%

The Staphylococcal Biofilm: Adhesins, Regulation, and Host Response

2016

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The Staphylococci comprise a diverse genus of Gram-positive, non-motile commensal organisms that inhabit the skin and mucous membranes of humans and other mammals. In general, Staphylococci are benign members of the natural flora, but many species have the capacity to be opportunistic pathogens, mainly infecting individuals who have medical device implants or are otherwise immunocompromised. S. aureus and S. epidermidis are a major source of hospital-acquired infections and are the most common causes of surgical site infections and central line-associated bloodstream infections. The ability of Staphylococci to form biofilms in vivo makes them highly resistant to chemotherapeutics and leads to chronic diseases. These biofilm infections include osteomyelitis, endocarditis, medical device implants, and persistence in the cystic fibrosis lung. Here, we provide a comprehensive analysis of our current understanding of Staphylococcal biofilm formation, with an emphasis on adhesins and regulation, while also addressing how Staphylococcal biofilms interact with the immune system. On the whole, this review will provide a thorough picture of biofilm formation of the Staphylococcus genus and how this mode of growth impacts the host.

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“…Again, release of MRP-14 into the supernatant was observed, in this case, independently of opsonization (Table 1). Concerning biofilms, apparently other recognition structures are displayed, possibly constituents of the extracellular matrix [30].…”

Section: Mrp-14 In the Peripheral Blood Of Patients With Infection Anmentioning

confidence: 99%

Neutrophil-derived MRP-14 is up-regulated in infectious osteomyelitis and stimulates osteoclast generation

Dapunt

Giese

Maurer

et al. 2015

Journal of Leukocyte Biology

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Bone infections of patients with joint replacement by endoprosthesis (so called “periprosthetic joint infection”) pose a severe problem in the field of orthopedic surgery. The diagnosis is often difficult, and treatment is, in most cases, complicated and prolonged. Patients often require an implant exchange surgery, as the persistent infection and the accompanying inflammation lead to tissue damage with bone degradation and consequently, to a loosening of the implant. To gain insight into the local inflammatory process, expression of the proinflammatory cytokine MRP-14, a major content of neutrophils, and its link to subsequent bone degradation was evaluated. We found MRP-14 prominently expressed in the affected tissue of patients with implant-associated infection, in close association with the chemokine CXCL8 and a dense infiltrate of neutrophils and macrophages. In addition, the number of MRP-14-positive cells correlated with the presence of bone-resorbing osteoclasts. MRP-14 plasma concentrations were significantly higher in patients with implant-associated infection compared with patients with sterile inflammation or healthy individuals, advocating MRP-14 as a novel diagnostic marker. A further biologic activity of MRP-14 was detected: rMRP-14 directly induced the differentiation of monocytes to osteoclasts, thus linking the inflammatory response in implant infections with osteoclast generation, bone degradation, and implant loosening.

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Immune Defense against S. Epidermidis Biofilms: Components of the Extracellular Polymeric Substance Activate Distinct Bactericidal Mechanisms of Phagocytic Cells

Cited by 34 publications

References 29 publications

Ventricular shunt infections: Immunopathogenesis and clinical management

Ventricular shunt infections: Immunopathogenesis and clinical management

The Staphylococcal Biofilm: Adhesins, Regulation, and Host Response

Neutrophil-derived MRP-14 is up-regulated in infectious osteomyelitis and stimulates osteoclast generation

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