Immune interferon gamma inhibits translational mobility of a plasma membrane protein in preimplantation stage mouse embryos: A T-helper 1 mechanism for immunologic reproductive failure

Enhanced Fertility After Diagnostic Hysterosalpingography Using Oil-Based Contrast Agents May Be Attributable to Immunomodulation

“…Interferon-γ has been shown to alter various plasma membrane domains and cytoskeletal organization in early-stage embryos [14]. These findings support the notion that Th2 bias in the uterine microenvironment may be vital for successful implantation.…”

Effect of Ovaric Hyper‐stimulation on Blood Lymphocyte Subpopulations, Cytokines, Leptin and Nitrite Among Patients with Unexplained Infertility

“…The increased values of both cytokines in patients and their decrease under hormonal stimulation suggest that they may be involved in infertility and support the hypothesis that a TH1‐biased immune response could be dangerous for pregnancy 25 . Most studies have pointed to IFN‐γ as the main suspect in immunologic reproductive failure, either at implantation 26 or later. Nevertheless, IFN‐γ has probably a dual role, at least in mice, because its production by uterine NK cells seems to be required for normal reproductive function 27 .…”

Maternal Tolerance to H‐Y is Independent of IL‐10

“…In such a role, IL-10 may mediate some directly protective effect against a directly toxic effect of an inflammatory mediator, such as TNFa (Polgar et al, 1996) or any other directly apoptotic signal (Aschkenazi et al, 2002). In such a role, IL-10 may mediate some directly protective effect against a directly toxic effect of an inflammatory mediator, such as TNFa (Polgar et al, 1996) or any other directly apoptotic signal (Aschkenazi et al, 2002).…”