Immune status of patients with different stages of colorectal cancer with and without circulating tumour cells

Sitkovskaya, Anastasia O.; Zlatnik, Elena Yu.; Novikova, Inna A.; Bondarenko, Elena S.; Sagakyants, Aleksandr B.; Vladimirova, Liubov Yu

doi:10.1093/annonc/mdz246.104

Cited by 2 publications

(2 citation statements)

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“…As an immune effector, it can participate in and regulate the humoral immune system of the body, including IgA, IgM and IgG (20). Sitkovskaya et al (21) measured the level of immune cells in patients with colorectal cancer at different stages, and found that CD4+ levels were increased in the early and late stages of the disease. Kim et al ( 22) significantly improved the mental and physical status of patients with colorectal cancer through a family health exercise program.…”

Section: Comparison Of Overall Nursing Satisfactionmentioning

confidence: 99%

The effect of 5A nursing combined with psychological nursing on the immune function, cancer-related fatigue and complications of patients undergoing radical resection of colorectal cancer

Yang²

2022

Cell Mol Biol (Noisy-le-grand)

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This study aimed to analyze the effects of 5A nursing (including Ask, Assess, Advise, Assist, and Access) combined with psychological nursing on the immune function, cancer-related fatigue, and complications of patients undergoing radical resection of colorectal cancer. For this purpose, 64 patients undergoing radical resection of colorectal cancer were treated with nursing intervention during the perioperative period from March 2019 to March 2021. They were randomly divided into a control group and a study group according to admission order. Each group had 32 cases. The control group performed routine nursing, and 5A nursing combined with psychological nursing was performed on the research group. Then the immune function, cancer-related fatigue, complications, self-efficacy, and nursing satisfaction were compared between the two groups. Results showed that the levels of CD3+ and CD4+ in the two groups were lower than before nursing, and the levels of CD8+, IgA, IgM, and IgG were higher than before nursing (P<0.05). The reduction of CD3+ and CD4+ in the study group was less than the control group, and the increase of CD8+, IgA, IgM, and IgG in the study group was higher than the control group (P<0.05). The scores of cancer-related fatigue after nursing were lower than before nursing (P<0.05), and the reduction of cancer-related fatigue in the study group was higher than the control group (P<0.05). The incidence of postoperative complications in the study group (12.50%) was lower than the control group (25.00%) after nursing (p<0.05). The scores of all dimensions of self-efficacy of the two groups after nursing were higher than before nursing (P<0.05). The improvement of self-efficacy of the study group was better than the control group (P<0.05). The overall nursing satisfaction of the observation group after nursing (96.88%) was higher than the control group (84.38%)(P<0.05). According to the results, the use of 5A nursing combined with psychological nursing can effectively relieve the perioperative psychological pressure of the patients, improve the immune function of the body, relieve cancer-related fatigue, prevent and control the incidence of complications, and improve the quality of clinical life of the patients for patients undergoing radical resection of colorectal cancer.

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Section: Comparison Of Overall Nursing Satisfactionmentioning

confidence: 99%

The effect of 5A nursing combined with psychological nursing on the immune function, cancer-related fatigue and complications of patients undergoing radical resection of colorectal cancer

Yang²

2022

Cell Mol Biol (Noisy-le-grand)

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“…When viewed through the lens of heterogeneous tumor architecture, temporal disease states, and diverse and dynamic cellular communities, we can begin to understand the complex changes in NK cell states produced by the sum of these elements. Both preclinical and clinical evidence point to a paradigm of continuous changes in NK cell development and activation over the course of cancer progression ( 1 , 17 , 18 ). Comparisons of NK cell states within the TME from early to advanced disease may provide insight into specific mechanisms that can be targeted to restore antitumor NK cell function in advanced cancers.…”

Section: Introductionmentioning

confidence: 99%

Back to the Future: Spatiotemporal Determinants of NK Cell Antitumor Function

O’Sullivan

2022

Front. Immunol.

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NK cells play a crucial role in host protection during tumorigenesis. Throughout tumor development, however, NK cells become progressively dysfunctional through a combination of dynamic tissue-specific and systemic factors. While a number of immunosuppressive mechanisms present within the tumor microenvironment have been characterized, few studies have contextualized the spatiotemporal dynamics of these mechanisms during disease progression and across anatomical sites. Understanding how NK cell immunosuppression evolves in these contexts will be necessary to optimize NK cell therapy for solid and metastatic cancers. Here, we outline the spatiotemporal determinants of antitumor NK cell regulation, including heterogeneous tumor architecture, temporal disease states, diverse cellular communities, as well as the complex changes in NK cell states produced by the sum of these higher-order elements. Understanding of the signals encountered by NK cells across time and space may reveal new therapeutic targets to harness the full potential of NK cell therapy for cancer.

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Immune status of patients with different stages of colorectal cancer with and without circulating tumour cells

Cited by 2 publications

References 0 publications

The effect of 5A nursing combined with psychological nursing on the immune function, cancer-related fatigue and complications of patients undergoing radical resection of colorectal cancer

The effect of 5A nursing combined with psychological nursing on the immune function, cancer-related fatigue and complications of patients undergoing radical resection of colorectal cancer

Back to the Future: Spatiotemporal Determinants of NK Cell Antitumor Function

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