Immunity to rubella among women of child‐bearing age

Lever, Andrew M. L.; Ross, M G; Baboonian, C.; Griffiths, Paul

doi:10.1111/j.1471-0528.1987.tb02355.x

Cited by 12 publications

(8 citation statements)

References 15 publications

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“…Seroprevalence is higher in European women (93.2%) than in women of African (86.7%) and Asian origin (78.4%) (Lever et al, 1987). In our study among pregnant women in Turkey, the seroprevalence was similar to that of European women.…”

Section: Discussionsupporting

confidence: 57%

Seroprevalence of Toxoplasma gondii and rubella among pregnant women in central Turkey

elen¹,

Sargin²,

Ccedil³

et al. 2013

Afr. J. Microbiol. Res.

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Infection with Toxoplasma gondii (T. gondii), when acquired in pregnancy, can lead to fetal infection, which may ultimately result in the loss of the fetus or in lesions involving the brain and the eyes. Rubella, when acquired in the first 12 weeks of pregnancy, is associated with a nearly 90% risk of congenital malformations. The aim of this study was to assess the seroprevalence of T. gondii and rubella among pregnant women at a tertiary referral hospital in central Turkey and to evaluate the use of our results for the prevention of congenital rubella syndrome (CRS) and congenital toxoplasmosis (CT). Data were obtained from the test results of sera collected from pregnant women during their first routine antenatal visit between 2008-2010. The results of the TORCH serology and avidity tests were evaluated. Age-specific subgroups were arranged for the rubella and T. gondii antibodies, and the distribution of seropositivity among the subgroups was assessed. Serum samples were evaluated for rubella (n=31385) and T. gondii (n=30863) IgG, IgM, and IgG avidity. The seropositivity of antibodies for T. gondii was 7869 (25.5%) and 83 (0.3%) for IgG and IgM, respectively. For rubella, the seropositivity was 29478 (93.9%) and 124 (0.4%) for IgG and IgM, respectively. In cases with both IgM and IgG, seropositivity avidity tests were performed. A high avidity of IgG antibodies was detected in 95 (76.6%) rubella cases and 30 (36.1%) T.gondii cases. Seropositivity for T. gondii increased significantly with age, while rubella seropositivity was high in all of the age-specific subgroups. In conclusion T. gondii and rubella are common causes of severe congenital infection. Widespread preventive antenatal measures and screening may help to protect against these teratogenic agents. Due to high seroprevalence of rubella, vaccination programs during childhood and preconceptional periods rather than antenatal screening appear to be more efficient for eliminating CRS. Avoidance of raw meat consumption, proper disposal of the fecal material of domestic animals, and elimination of oocysts from raw food are the main measures to prevent infection with T. gondii. Antenatal screening for toxoplasmosis is warranted, considering the low seroprevalence and serious fetal hazards of congenital infection.

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Section: Discussionsupporting

confidence: 57%

Seroprevalence of Toxoplasma gondii and rubella among pregnant women in central Turkey

elen¹,

Sargin²,

Ccedil³

et al. 2013

Afr. J. Microbiol. Res.

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“…This study in Sydney found relatively high levels of immunity to rubella amongst confinements and has identified groups which might possibly be targeted for population‐based educational interventions aimed at improving immunity amongst women of child‐bearing age. As in other countries, country of birth was found to be a highly significant factor in determining rubella immune status 7–10 . Specifically, we identified that Asian‐born women were 7 times more likely to be non‐immune to rubella than Australian‐born women.…”

Section: Discussionmentioning

confidence: 53%

Factors associated with low immunity to rubella infection on antenatal screening

Sathanandan

Gupta

Liu

et al. 2005

Aust NZ J Obst Gynaeco

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“…A study has reported 5-50% incidence rate of congenital Rubella when the mother is infected in the first trimester of her pregnancy (Miller et al, 1982). In a study, approximately 12% of pregnant women were found to be seroposititve for rubella and about 10-20% of women in the child bearing age were susceptible for the rubella infection (Rubella and Pregnancy, 1993;Lever et al, 1987). Our study has reported a statistically significant difference between the two groups i.e., cases and controls.…”

Section: Resultsmentioning

confidence: 99%

A Study of Torch Screening in Women with Bad Obstetric History

Mustafa¹,

Sultana²,

Begum³

et al. 2018

Int.J.Curr.Microbiol.App.Sci

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Journal homepage: http://www.ijcmas.com Maternal infections have been considered as one of the significant factors in the causation of bad obstetric history. Infections caused by Toxoplasma, Rubella, Cytomegalovirus and Herpes simplex virus are benign. However, they may lead to serious complications, especially when they are acquired during the first trimester of pregnancy. These are associated with inadvertent outcomes like multiple abortions, intra-uterine fetal death, stillbirths and congenital malformations. Data regarding the detection of these infections is scanty as the risk requirement of expensive commercial diagnostic kit-Toxoplasma, Rubella, Cytomegalovirus and Herpes simplex IgM antibodies. This study was undertaken to assess the utility in pregnant women with bad obstetric history. The present study was undertaken as the case-control study at Princess Esra Hospital, Hyderabad between January 2015 and December 2017. A total of 50 pregnant women of age range in their first trimester attending Ante Nata Clinic were included along with 35 age matched control pregnant women with no bad obstetric history. After obtaining the institutional ethics committee approval serum samples were obtained aseptically from the enrolled cases and were tested for the identification of specific IgM antibodies for Toxoplasma, Rubella, Cytomegalovirus and Herpes using sandwich and capture ELIZA (Calbiotech lab USA). The assay was performed according to the manufacturer's instructions and the results were calculated in MS excel and test of proportion and Pearson's Chi square test. 23 women for IgM antibodies Toxoplasma, Rubella, Cytomegalovirus and Herpes either alone or in combination were identified in the group I. In the control group (Group II), IgM antibodies were detected in 11 cases. When compared with the control group, Rubella and Toxoplasma infection were found to have statistically significant difference with the pvalue of 0.016 and 0.026 respectively. However, there was no statistically significant difference found between the two study groups. Detection of IgM antibodies performed reflects recent infection and there is high prevalence of infection caused by TORCH agents in women with bad obstetric history compared to healthy controls. Hence, all the anti-natal cases with bad obstetric history should be routinely screened as IgM antibodies detection is a reliable indicator of maternal infections and can be used as a screening test. K e y w o r d s

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Immunity to rubella among women of child‐bearing age

Cited by 12 publications

References 15 publications

Seroprevalence of Toxoplasma gondii and rubella among pregnant women in central Turkey

Seroprevalence of Toxoplasma gondii and rubella among pregnant women in central Turkey

Factors associated with low immunity to rubella infection on antenatal screening

A Study of Torch Screening in Women with Bad Obstetric History

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