Immunobiological responses to short carbohydrate epitopes in Trypanosoma cruzi

Carbohydrate immunity in American trypanosomiasis

“…Although anti-Gal from healthy individuals and from patients with Chagas disease and American cutaneous leishmaniasis react with mouse laminin [91], the main antibody targets on T. cruzi are still under study and seem to differ in different developmental stages of the parasite. Chagasic anti-Gal immunoprecipitates a major 70-to 72-kDa glycoprotein from 12SI-labeled lysates of metacyclic trypomastigotes [92]. An 85-kDa membrane glycoprotein from cell culture trypomastigotes express oligosaccharides with terminal sialyl and Gal~(1 ~ 3)-Gal units [18], a structure that parallels the double-substituted antenary N-linked carbohydrate chains of mammalian glycoproteins.…”

Polyclonal B-Cell activation byNeisseria meningitidis capsular polysaccharides elicit antibodies protective againstTrypanosoma cruzi infection in vitro

“…Previous results from our laboratory (18) showed that an antigroup-C Neisseria meningitidis hyperimmune rabbit antiserum agglutinated metacyclic trypomastigotes of both T. cmzi strains G and Y. Assuming that this reactivity was due…”