Immunochemical characteristics of synthetic peptides with T-cellular and B-cellular epitopes of nonspecific porins of pathogenic Yersinia

Immunochemical Properties of Recombinant Ompf Porin from Outer Membrane of Yersinia pseudotuberculosis

“…Besides, this result was consistent with the antigenic determinants calculated theoretically using various computer programs (ProPred, SYFPEITHI, and RANKPEP) and allowed us to predict the regions of interaction with the T-receptors on the surface of human lymphocytes. According the data obtained by this software it was found that less than 20% of the total number of calculated peptides coincided with the porin external loops areas and the significant part of the latter occured in the loop 8 (Portnyagina et al, 2010). Zwiterrgent 3 -14 (RP/Zw).…”

“…At the present special interest to the problem of yersiniosis is connected with the immunopathologies, so-called secondary yersiniosis (or second-hearth) forms (arthritis, myocardit, neuralgia, collagenosis) caused in patients by Yersinia infection. The etiology of such immunopathologies is not determined in practice because of the absence of specific diagnostic methods (Portnyagina et al, 2010).…”

“…Therefore, the creation of polyvalent vaccine protecting from plague, intestinal yersiniosis, and pseudotuberculosis is the urgent task. The high degree of homology of Yersinia porin primary structures (Guzev et al, 2005;Likhatskaya et al, 2005;Issaeva et al, 2003) is a basis for creation of the vaccine preparations that will protect against all infections caused by pathogenic Yersinia species (Antonets et al, 2007;Portnyagina et al, 2010).…”

Trends in Immunolabelled and Related Techniques

“…Besides, this result was consistent with the antigenic determinants calculated theoretically using various computer programs (ProPred, SYFPEITHI, and RANKPEP) and allowed us to predict the regions of interaction with the T-receptors on the surface of human lymphocytes. According the data obtained by this software it was found that less than 20% of the total number of calculated peptides coincided with the porin external loops areas and the significant part of the latter occured in the loop 8 (Portnyagina et al, 2010).…”